Seminars in Hematology
Volume 49, Issue 1 , Pages 15-24 , January 2012

Late Pulmonary Complications After Allogeneic Hematopoietic Stem Cell Transplantation: Diagnosis, Monitoring, Prevention, and Treatment

  • Andrea Bacigalupo

      Affiliations

    • Unità Operativa Ematologia 2, Azienda Ospedaliera Universitaria “San Martino”, Genova, Italy
    • Corresponding Author InformationAddress correspondence to Andrea Bacigalupo, MD, Unità Operativa Ematologia 2, Azienda Ospedaliera Universitaria “San Martino”, Largo Rosanna Benzi, 10, 16132 Genova, Italy
  • ,
  • Jason Chien

      Affiliations

    • Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
  • ,
  • Giovanni Barisione

      Affiliations

    • Unità Operativa Medicina Preventiva e del Lavoro, Laboratorio di Fisiopatologia Respiratoria, Azienda Ospedaliera Universitaria “San Martino”, Genova, Italy
  • ,
  • Steven Pavletic

      Affiliations

    • Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD

References 

  1. Chien JW , Duncan S , Williams KM , Pavletic SZ . Bronchiolitis obliterans syndrome after allogeneic hematopoietic stem cell transplantation-an increasingly recognized manifestation of chronic graft-versus-host disease . Biol Blood Marrow Transplant . 2010;16:S106–S114
  2. Santo Tomas LH , Loberiza FR , Klein JP , et al.  Risk factors for bronchiolitis obliterans in allogeneic hematopoietic stem-cell transplantation for leukemia . Chest . 2005;128:153–161
  3. Filipovich AH , Weisdorf D , Pavletic S , et al.  National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I (Diagnosis and staging working group report) . Biol Blood Marrow Transplant . 2005;11:945–956
  4. Au BK , Au MA , Chien JW . Bronchiolitis obliterans syndrome epidemiology after allogeneic hematopoietic cell transplantation . Biol Blood Marrow Transplant . 2011;17:1072–1078
  5. Clark JG , Crawford SW , Madtes DK , Sullivan KM . Obstructive lung disease after allogeneic marrow transplantation (Clinical presentation and course) . Ann Intern Med . 1989;111:368–376
  6. Williams KM , Chien JW , Gladwin MT , Pavletic SZ . Bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation . JAMA . 2009;302:306–314
  7. Barisione G , Bacigalupo A , Crimi E , Brusasco V . Acute bronchodilator responsiveness in bronchiolitis obliterans syndrome following hematopoietic stem cell transplantation . Chest . 2011;139:633–639
  8. Gunn ML , Godwin JD , Kanne JP , Flowers ME , Chien JW . High-resolution CT findings of bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation . J Thorac Imaging . 2008;23:244–250
  9. Yokoi T , Hirabayashi N , Ito M , et al.  Broncho-bronchiolitis obliterans as a complication of bone marrow transplantation: a clinicopathological study of eight autopsy cases . Virchows Arch . 1997;431:275–282
  10. Weibel ER . Design of airways and blood vessels considered as branching trees . In:  Crystal RG ,  West JB editor. The lung: scientific foundations . Philadelphia: Lippincott-Raven; 1997;p. 1061–1071
  11. Yanai M , Sekizawa K , Ohrui T , Sasaki H , Takishima T . Site of airway obstruction in pulmonary disease: direct measurement of intrabronchial pressure . J Appl Physiol . 1992;72:1016–1023
  12. Mead J . The lung's “quiet zone” . N Engl J Med . 1970;282:1318–1319
  13. Brown R , Woolcock AJ , Vincent NJ , Macklem PT . Physiological effects of experimental airway obstruction with beads . J Appl Physiol . 1969;27:328–335
  14. Wood LD , Engel LA , Griffin P , Despas P , Macklem PT . Effect of gas physical properties and flow on lower pulmonary resistance . J Appl Physiol . 1976;41:234–244
  15. Macklem PT , Proctor DF , Hogg JC . The stability of peripheral airways . Respir Physiol . 1970;8:191–203
  16. Hughes JMB , Rosenzweig DY , Kivitz PB . Site of airway closure in excised dog lungs: histologic demonstration . J Appl Physiol . 1970;29:340–344
  17. Barisione G , Bacigalupo A , Crimi E , Van Lint MT , Lamparelli T , Brusasco V . Lung volumes and airway responsiveness following haematopoietic stem cell transplantation . Eur Respir J . 2008;32:1576–1582
  18. Chacon RA , Corris PA , Dark JH , Gibson GJ . Tests of airway function in detecting and monitoring treatment of obliterative bronchiolitis after lung transplantation . J Heart Lung Transplant . 2000;19:263–269
  19. Estenne M , Van Muylem A , Knoop C , Antoine M . Detection of obliterative bronchiolitis after lung transplantation by indexes of ventilation distribution . Am J Respir Crit Care Med . 2000;162:1047–1051
  20. Verbanck S , Schuermans D , Van Muylem A , Paiva M , Noppen M , Vincken W . Ventilation distribution during histamine provocation . J Appl Physiol . 1997;83:1907–1916
  21. Peslin R , Fredberg JJ . Oscillation mechanics of the respiratory system . In:  Macklem PT editors. Handbook of physiology (Section 3: The respiratory system) . Bethesda, MD: American Physiological Society; 1986;p. 145–177
  22. Lutchen KR , Greenstein JL , Suki B . How inhomogeneities and airway walls affect frequency dependence and separation of airway and tissue properties . J Appl Physiol . 1996;80:1696–1707
  23. Lee SJ , Vogelsang G , Gilman A , Weisdorf DJ , et al.  A survey of diagnosis, management and grading of Chronic GVHD . Biol Blood Marrow Transplant . 2002;8:32–39
  24. Goerner M , Gooley T , Flowers ME , et al.  Morbidity and mortality of chronic GVHD after hematopoietic stem cell transplantation from HLA-identical siblings for patients with aplastic or refractory anemias . Biol Blood Marrow Transplant . 2002;8:47–56
  25. Weisdorf DJ , Anasetti C , Antin JH , et al.  Allogeneic bone marrow transplantation for chronic myelogenous leukemia: comparative analysis of unrelated versus matched sibling donor transplantation . Blood . 2002;99:1971–1977
  26. Duggan P , Booth K , Chaudhry A , et al.  Unrelated donor BMT recipients given pretransplant low-dose antithymocyte globulin have outcomes equivalent to matched sibling BMT: a matched pair analysis . Bone Marrow Transplant . 2002;30:681–686
  27. Finke J , Bertz H , Schmoor C , et al.  Allogeneic bone marrow transplantation from unrelated donors using in vivo anti-T-cell globulin . Br J Haematol . 2000;111:303–313
  28. Remberger M , Storer B , Ringden O , Anasetti C . Association between pre-transplant Thymoglobuline and reduced non relapse mortality rate after marrow transplantation from unrelated donors . Bone Marrow Transplant . 2002;29:391–397
  29. Kroger N , Zabelina T , Kruger W , et al.  In vivo T-cell depletion with re-transplant anti-thymocyte globulin reduces graft vs host disease, without increasing relapse in good risk myeloid leukemia patients after stem cell transplantation from matched related donors . Bone Marrow Transplant . 2002;29:683–689
  30. Zander AR , Kroger N , Schleuning M , et al.  ATG as part of the conditioning regimen reduces transplant related mortality (TRM) and improves overall survival after unrelated stem cell transplantation in patients with chronic meyloid leukemia . Bone Marrow Transplant . 2003;32:355–361
  31. Bacigalupo A , Lamparelli T , Gualandi F , et al.  Prophylactic antithymocyte globulin reduces the risk of chronic graft-versus-host disease in alternative-donor bone marrow transplants . Biol Blood Marrow Transplant . 2002;8:656–661
  32. Bacigalupo A . Antilymphocyte globulin for graft versus host disease prophylaxis: efficacy and side effects . Bone Marrow Transplant . 2004;1:7
  33. Weiden PL , Doney K , Storb R , Thomas ED . Antihuman thymocyte globulin for prophylaxis of graft-versus-host disease (A randomized trial in patients with leukemia treated with HLA-identical sibling marrow grafts) . Transplantation . 1979;27:227
  34. Ramsay NKC , Kersey JH , Robinson LL , et al.  A randomized study of the prevention of acute graft versus host disease . N Engl J Med . 1982;306:392–397
  35. Bacigalupo A , Lamparelli T , Bruzzi P , et al.  Antithymocyte globulin for graft-versus-host disease prophylaxis in transplants from unrelated donors: 2 randomized studies from Gruppo Italiano Trapianti Midollo Osseo (GITMO) . Blood . 2001;98:2942–2947
  36. Bacigalupo A , Lamparelli T , Barisione G , et al.  Thymoglobulin prevents chronic graft-versus-host disease, chronic lung dysfunction, and late transplant-related mortality: long-term follow-up of a randomized trial in patients undergoing unrelated donor transplantation . Biol Blood Marrow Transplant . 2006;12:560–565
  37. Finke J , Bethge WA , Schmoor C , et al.  Standard graft-versus-host disease prophylaxis with or without anti-T-cell globulin in haematopoietic cell transplantation from matched unrelated donors: a randomised, open-label, multicentre phase 3 trial . Lancet Oncol . 2009;10:855–864
  38. Socié G , Schmoor C , Bethge WA , et al.  Chronic graft-versus-host disease: long-term results from a randomized trial on graft-versus-host disease prophylaxis with or without anti-T-cell globulin ATG-Fresenius . Blood . 2011;117:6375–6382
  39. Pavletic SZ , Carter SL , Kernan NA , et al.  Influence of T-cell depletion on chronic graft-versus-host disease: results of a multicenter randomized trial in unrelated marrow donor transplantation . Blood . 2005;106:3308–3313
  40. Pavletic SZ , Martin P , Lee SJ , et al.  Measuring therapeutic response in chronic graft-versus-host disease: National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IV. Response Criteria Working Group report (Response Criteria Working Group) . Biol Blood Marrow Transplant . 2006;12:252–266
  41. Chien JW , Martin PJ , Gooley TA , et al.  Airflow obstruction after myeloablative allogeneic hematopoietic stem cell transplantation . Am J Respir Crit Care Med . 2003;168:208–214
  42. Hildebrandt GC , Fazekas T , Lawitschka A , et al.  Diagnosis and treatment of pulmonary chronic GVHD: report from the consensus conference on clinical practice in chronic GVHD . Bone Marrow Transplant . 2011;46:1283–1295
  43. Martin PJ , Pavletic SZ . Biology and management of chronic graft-versus-host disease . Cancer Treat Res . 2009;144:277–298
  44. Couriel D , Carpenter PA , Cutler C , et al.  Ancillary therapy and supportive care of chronic graft-versus-host disease: National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-Versus-Host Disease: V (Ancillary Therapy and Supportive Care Working Group Report) . Biol Blood Marrow Transplant . 2006;12:375–396
  45. Chien JW . Preventing and managing bronchiolitis obliterans syndrome after allogeneic hematopoietic cell transplantation . Expert Rev Respir Med . 2011;5:127–135
  46. Norman BC , Jacobsohn DA , Williams KM , et al.  Fluticasone, azithromycin and montelukast therapy in reducing corticosteroid exposure in bronchiolitis obliterans syndrome after allogeneic hematopoietic SCT: a case series of eight patients . Bone Marrow Transplant . 2011;46:1369–1373
  47. Pidala J , Lee SJ , Quinn G , Jim H , Kim J , Anasetti C . Variation in management of immune suppression after allogeneic hematopoietic cell transplantation . Biol Blood Marrow Transplant . 2011;17:1528–1536
  48. Vogelsang G . The doorstep to the temple of wisdom . Biol Blood Marrow Transplant . 2011;17:1417–1418
  49. Martin PJ , Weisdorf D , Przepiorka D , et al.  National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-Versus-Host Disease: VI. Design of Clinical Trials Working Group report (Design of Clinical Trials Working Group) . Biol Blood Marrow Transplant . 2006;12:491–505
  50. Vanaudenaerde BM , Meyts I , Vos R , et al.  A dichotomy in bronchiolitis obliterans syndrome after lung transplantation revealed by azithromycin therapy . Eur Respir J . 2008;32:832–843
  51. Holbro A , Lehmann T , Gambazzi F , et al.  The histological pattern of lung biopsy predicts outcome of bronchiolitis obliterans syndrome after allogeneic hematopoietic stem cell transplantation . Bone Marrow Transplant . 2011;46:S9–S10
  52. Lorillon G , Robin M , Meignin V , et al.  Rituximab in bronchiolitis obliterans after haematopoietic stem cell transplantation . Eur Respir J . 2011;38:470–472
  53. Lam DC , Lam B , Wong MK , et al.  Effects of azithromycin in bronchiolitis obliterans syndrome after hematopoietic SCT—a randomized double-blinded placebo-controlled study . Bone Marrow Transplant . 2011 Feb 14; [Epub ahead of print]

 This work was supported by Associazione Italiana Ricerca contro il Cancro (A.I.R.C.), Milano, and Fondazione Ricerca Trapianto di Midollo Osseo (FA-RI.T.M.O.), Genova, Italy

 Conflict of interest: the authors have no conflict of interest to declare

PII: S0037-1963(11)00099-0

doi: 10.1053/j.seminhematol.2011.10.005

Seminars in Hematology
Volume 49, Issue 1 , Pages 15-24 , January 2012