Seminars in Hematology
Volume 49, Issue 1 , Pages 15-24 , January 2012

Late Pulmonary Complications After Allogeneic Hematopoietic Stem Cell Transplantation: Diagnosis, Monitoring, Prevention, and Treatment

  • Andrea Bacigalupo

      Affiliations

    • Unità Operativa Ematologia 2, Azienda Ospedaliera Universitaria “San Martino”, Genova, Italy
    • Corresponding Author InformationAddress correspondence to Andrea Bacigalupo, MD, Unità Operativa Ematologia 2, Azienda Ospedaliera Universitaria “San Martino”, Largo Rosanna Benzi, 10, 16132 Genova, Italy
    • ,
  • Jason Chien

      Affiliations

    • Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
    • ,
  • Giovanni Barisione

      Affiliations

    • Unità Operativa Medicina Preventiva e del Lavoro, Laboratorio di Fisiopatologia Respiratoria, Azienda Ospedaliera Universitaria “San Martino”, Genova, Italy
    • ,
  • Steven Pavletic

      Affiliations

    • Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD

  • Image Result

    Incidence of extensive chronic graft-versus-host disease (cGVHD) at last follow up, is lower in patients receiving rabbit anti-thymocyte globulin (ATG) in the conditioning regimen: this is true for bo

    Incidence of extensive chronic graft-versus-host disease (cGVHD) at last follow up, is lower in patients receiving rabbit anti-thymocyte globulin (ATG) in the conditioning regimen: this is true for both the Italian (GITMO) trial and the German more recent trial. Reduction is almost exactly of the same order, despite difference in transplant era, patient numbers, donor selection, and ATG source (the GITMO trial was conducted with Thymoglobulin and the German trial with ATG-F).

 This work was supported by Associazione Italiana Ricerca contro il Cancro (A.I.R.C.), Milano, and Fondazione Ricerca Trapianto di Midollo Osseo (FA-RI.T.M.O.), Genova, Italy

 Conflict of interest: the authors have no conflict of interest to declare

PII: S0037-1963(11)00099-0

doi: 10.1053/j.seminhematol.2011.10.005

Seminars in Hematology
Volume 49, Issue 1 , Pages 15-24 , January 2012

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