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Seminars in Hematology
Volume 47, Issue 3
, Pages 249-257
, July 2010
Clinical Findings With the First Generation of Thrombopoietic Agents
References
- . The thrombocytopenia of cancer (Prospects for effective cytokine therapy). Hematol Oncol Clin North Am. 1996;10:431–455
- . Thrombopoietin: biology and potential clinical applications. Oncology (Huntingt). 1998;12:1597–1604
- Incidence, cost, and outcomes of bleeding and chemotherapy dose modification among solid tumor patients with chemotherapy-induced thrombocytopenia. J Clin Oncol. 2001;19:1137–1146
- . What is the proper threshold for platelet transfusion in patients with chemotherapy-induced thrombocytopenia?. Crit Rev Oncol Hematol. 2002;42:163–171
- Platelet transfusion for patients with cancer: clinical practice guidelines of the American Society of Clinical Oncology. J Clin Oncol. 2001;19:1519–1538
- . Thrombopoietic growth factors and cytokines. Curr Hematol Rep. 2005;4:137–144
- . Recombinant human thrombopoietin: basic biology and evaluation of clinical studies. Blood. 2002;100:3457–3469
- A randomized placebo-controlled trial of recombinant human interleukin-11 in cancer patients with severe thrombocytopenia due to chemotherapy. Blood. 1996;87:3607–3614
- Thrombopoietic effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in patients with advanced cancer. Lancet. 1996;348:1279–1281
- Stimulation of megakaryocyte and platelet production in a single dose of recombinant human thrombopoietin in patients with cancer. Ann Intern Med. 1997;126:673–681
- Effects of polyethylene glycol-conjugated recombinant human megakaryocyte growth and development factor on platelet counts after chemotherapy for lung cancer. N Engl M Med. 1997;336:404–409
- Randomized, blinded, placebo-controlled phase I trial of pegylated recombinant human magakaryocyte growth and development factors with filgrastim after dose-intensive chemotherapy in patients with advanced cancer. Blood. 1997;89:3118–3128
- Recombinant human thrombopoietin attenuates carboplatin-induced severe thrombocytopenia and the need for platelet transfusions in patients with gynecologic cancer. Ann Intern Med. 2000;132:364–368
- Thrombopoietin mobilizes CD34+ cell subsets into peripheral blood and expands multilineage progenitors in bone marrow of cancer patients with normal hematopoiesis. Exp Hematol. 1998;26:207–216
- Enhancement of platelet recovery after myelosuppressive chemotherapy by recombinant human megakaryocyte growth and development factor in patients with advanced cancer. J Clin Oncol. 2000;18:2852–2861
- Schedule-dependent reduction in thrombocytopenia by recombinant human thrombopoietin (rhTPO) in patients with sarcoma receiving high dose chemotherapy (CT) with adriamycin (A) and ifosfamide (I) [abstract]. J Clin Oncol. 1999;18:52a
- A randomized, placebo-controlled, blinded, dose scheduling trial of pegylated recombinant human megakaryocyte growth and development factor (PEG-HUMGDF) with filgrastim support in non small cell lung cancer (NSCLC) patients treated with paclitaxel and carboplatin during multiple cycles of chemotherapy [abstract]. Proc Am Soc Clin Oncol. 1998;17:73a
- Importance of predosing of recombinant human thrombopoietin to reduce chemotherapy-induced early thrombocytopenia. J Clin Oncol. 2003;21:3158–3167
- Maintaining the dose intensity of ICE chemotherapy with a thrombopoietic agent, PEG-rHuMGDF, may confer a survival advantage in relapsed and refractory aggressive non-Hodgkin lymphoma. Ann Oncol. 2007;18:1842–1850
- A phase I clinical, pharmacologic, and biologic study of thrombopoietin and granulocyte colony-stimulating factors in children receiving ifosfamide, charboplatin, and etoposide chemotherapy for recurrent or refractory solid tumors: a Children's Oncology Group experience. Clin Cancer Res. 2005;11:2644–2650
- A randomized, double-blind, placebo-controlled study with pegylated recombinant human megakaryocyte growth and development factors (PEG-rHuMGDF) as an adjunct to chemotherapy for adults with de-novo acute myeloid leukemia. Blood. 1999;94:3694–3701
- A double-blind, placebo-controlled trial of pegylated recombinant human megakaryocyte growth and development factor as an adjunct to induction and consolidation therapy for patients with acute myeloid leukemia. Blood. 2000;95:2530–2535
- A pilot study of recombinant human thrombopoietin (rh-TPO) and GM-CSF following induction therapy in patients older than 55 years with acute myeloid leukemia (AML) [abstract]. Blood. 1998;92:616a
- Prior and concurrent administration of recombinant human megakaryocyte growth and development factor in patients receiving consolidation chemotherapy for the novo acute myeloid leukemia—a randomized, placebo-controlled, double-blind safety and efficacy study. Ann Hematol. 2003;95:2530–2535
- Phase I study of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in breast cancer patients after autologous peripheral blood progenitor cell (PBPC) transplantation. Bone Marrow Transplant. 2000;26:141–145
- Recombinant human thrombopoietin (rhTPO) after autologous bone marrow transplantation: a phase I pharmacokinetic and pharmacodynamic study. Bone Marrow Transplant. 2001;27:261–268
- The effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) on platelet recovery in breast cancer patients undergoing autologous bone marrow transplantation. Exp Hematol. 2002;30:1044–1050
- A phase I trial of recombinant human thrombopoietin in patients with delayed platelet recovery after hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2000;6:25–34
- Recombinant human thrombopoietin in combination with granulocyte colony-stimulating factor enhances mobilization of peripheral blood progenitor cells, increases peripheral blood platelet concentration, and accelerates hematopoietic recovery following high-dose chemotherapy. Blood. 1999;93:2798–2806
- A randomized, placebo-controlled, phase II trial of recombinant human thrombopoietin (rhTPO) in subjects undergoing high dose chemotherapy (HDC and PBPC transplant [abstract]. Blood. 1998;92:682a
- . Thrombopoietin in the treatment of acute myeloid leukemia and in stem-cell transplantation. Semin Hematol. 2000;37:35–40
- Thrombopoietin therapy increases platelet yields in healthy platelet donors. Blood. 2001;98:1339–1345
- Prophylactic platelet transfusions from healthy apheresis platelet donors undergoing treatment with thrombopoietin. Blood. 2001;98:1346–1351
- Vadhan-Raj S, Kavanagh JJ, Freedman RS, et al. Safety and efficacy of transfusions of autologous cryopreserved platelets derived from recombinant human thrombopoietin to support chemotherapy-associated severe thrombocytopenia: a randomized cross-over study. Lancet. 220;359:2145-52.
- Megakaryopoiesis in vitro in myelodysplastic syndromes and acute myeloid leukaemia: effect of pegylated recombinant human megakaryocyte growth and development factor in combination with other growth factors. Br J Haematol. 2000;108:743–746
- Analysis of megakaryocyte growth and development factor (thrombopoietin) effects on blast cell and megakaryocyte growth in myelodysplasia. Leuk Res. 1998;22;:527–535
- Pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) increased platelet counts (plt) in patients with aplastic anemia (AA) and myelodysplastic syndrome (MDS) [abstract]. Blood. 2000;96:296a
- Stimulation of nonclonal hematopoiesis and suppression of the neoplastic clone after treatment with recombinant human granulocyte-macrophage colony-stimulating factor in a patient with therapy-related myelodysplastic syndrome. Blood. 1989;74:1491–1498
- . Effects of pegylated recombinant human megakaryocyte growth and development factor in patients with idiopathic thrombocytopenic purpura. Blood. 2002;68:210–214
- . Cyclic immune thrombocytopenia responsive to thrombopoietic growth factor therapy. Am J Hematol. 2001;68:210–214
- Treatment of thrombocytopenia in chimpanzees infected with human immunodeficiency virus by pegylated recombinanat human megakaryocyte growth and development factor. Blood. 1998;91:4427–4433
- Correction of thrombocytopenia and ineffective platelet production in patients infected with human immunodeficiency virus (HIV) by PEG-rHuMGDF therapy [abstract]. Blood. 1998;92(Suppl 1):707a
- . Thrombopoietin administered during induction chemotherapy to patients with acute myeloid leukemia induces transient morphologic changes that may resemble chronic myeloproliferative disorders. Am J Clin Pathol. 2002;117:844–850
- Vigon I, Dreyfus F, Melle J, et al. Expression of the c-mpl proto-oncogene in human hematologic malignancies. Blood. 82;877-83.
- Thrombocytopenia caused by the development of antibodies to thrombopoietin. Blood. 2001;98:3241–3248
- . The appearance of anti-thrombopoietin antibody and circulating thrombopoietin after multicycle chemotherapy supported by megakaryocyte growth and development factor [abstract]. Blood. 1999;94:681a
- Development of pancytopenia with neutralizing antibodies to thrombopoietin after multicycle chemotherapy supported by megakaryocyte growth and development factor. Blood. 2002;99:2599–2602
- Thrombocytopenia associated with administration of a C-MPL receptor agonist. Am Soc Clin Oncol. 2000;53a:Abstract 206
- . New thrombopoietic growth factors. Blood. 2007;109:4607–4616
- . Evaluation of AMG 351 in chemotherapy-induced thrombocytopenia (CIT): results of a phase I/II study. Am Soc Clin Oncol. 2009;abstract e20616
- Safety of romiplostim for treatment of chemotherapy-induced thrombocytopenia (CIT) in patients with advanced non-small cell lung cancer (NSCLC). 2009;ECCO-ESMO Congress; Berlin
- . Safety of romiplostim for treatment of severe chemotherapy induced thrombocytopenia (CIT) in patients with lymphoma receiving multicycle chemotherapy; results from an open-label dose-and schedule finding study. 2009;(NSCLC). ECCO-ESMO Congress; Berlin
PII: S0037-1963(10)00045-4
doi: 10.1053/j.seminhematol.2010.03.004
© 2010 Elsevier Inc. All rights reserved.
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Seminars in Hematology
Volume 47, Issue 3
, Pages 249-257
, July 2010
