« Previous
Next »
Seminars in Hematology
Volume 47, Issue 2
, Pages 107-114
, April 2010
CD20 as a Target for Therapeutic Type I and II Monoclonal Antibodies
References
- . Characterization of a human B lymphocyte-specific antigen. J Immunol. 1980;125:1678–1685
- . CD20: a regulator of cell-cycle progression of B lymphocytes. Immunol Today. 1994;15:450–454
- . A unique cell surface antigen identifying lymphoid malignancies of B cell origin. J Clin Invest. 1981;67:134–140
- . Further biochemical studies of the human B-cell differentiation antigens B1 and B2. Hybridoma. 1983;2:17–28
- . Identification of a new multigene four-transmembrane family (MS4A) related to CD20, HTm4 and beta subunit of the high-affinity IgE receptor. Gene. 2001;264:87–93
- . Structural organization of the human MS4A gene cluster on chromosome 11q12. Immunogenetics. 2001;53:357–368
- . Isolation and structure of a cDNA encoding the B1 (CD20) cell-surface antigen of human B lymphocytes. Proc Natl Acad Sci U S A. 1988;85:208–212
- . Identification of a cytoplasmic region of CD20 required for its redistribution to a detergent-insoluble membrane compartment. J Immunol. 1998;161:3242–3248
- . Isolation and characterization of the B-cell marker CD20. Biochemistry. 2005;44:15150–15158
- . Phosphorylation of the B1 (CD20) molecule by normal and malignant human B lymphocytes. J Biol Chem. 1988;263:10009–10015
- Activation of human B cells (Comparison of the signal transduced by IL-4 to four different competence signals). J Immunol. 1989;143:3873–3880
- The biological activity of human CD20 monoclonal antibodies is linked to unique epitopes on CD20. J Immunol. 2006;177:362–371
- . Alanine-170 and proline-172 are critical determinants for extracellular CD20 epitopes; heterogeneity in the fine specificity of CD20 monoclonal antibodies is defined by additional requirements imposed by both amino acid sequence and quaternary structure. Blood. 2002;99:3256–3262
- . Structure of the Fab fragment of therapeutic antibody ofatumumab provides insights into the recognition mechanism with CD20. Mol Immunol. 2009;46:2419–2423
- Structural basis for recognition of CD20 by therapeutic antibody rituximab. J Biol Chem. 2007;282:15073–15080
- . CD20 homo-oligomers physically associate with the B cell antigen receptor (Dissociation upon receptor engagement and recruitment of phosphoproteins and calmodulin-binding proteins). J Biol Chem. 2008;283:18545–18552
- The CD20 calcium channel is localized to microvilli and constitutively associated with membrane rafts: antibody binding increases the affinity of the association through an epitope-dependent cross-linking-independent mechanism. J Biol Chem. 2004;279:19893–19901
- . A cholesterol-dependent CD20 epitope detected by the FMC7 antibody. Leukemia. 2003;17:1384–1389
- . Supramolecular complexes of MHC class I, MHC class II, CD20, and tetraspan molecules (CD53, CD81, and CD82) at the surface of a B cell line JY. J Immunol. 1996;157:2939–2946
- . CD20 is physically and functionally coupled to MHC class II and CD40 on human B cell lines. Eur J Immunol. 1999;29:65–74
- . Colocalization of the B cell receptor and CD20 followed by activation-dependent dissociation in distinct lipid rafts. J Immunol. 2002;169:2886–2891
- Induction of cytosolic calcium flux by CD20 is dependent upon B Cell antigen receptor signaling. J Biol Chem. 2008;283:16971–16984
- . Mice carrying a CD20 gene disruption. Immunogenetics. 1998;48:125–132
- Mouse CD20 expression and function. Int Immunol. 2004;16:119–129
- . Transfection of the CD20 cell surface molecule into ectopic cell types generates a Ca2+ conductance found constitutively in B lymphocytes. J Cell Biol. 1993;121:1121–1132
- . Expression of calcium-permeable cation channel CD20 accelerates progression through the G1 phase in Balb/c 3T3 cells. J Biol Chem. 1995;270:13099–13104
- . Store-operated cation entry mediated by CD20 in membrane rafts. J Biol Chem. 2003;278:42427–42434
- . The CD20 (Bp35) antigen is involved in activation of B cells from the G0 to the G1 phase of the cell cycle. J Immunol. 1985;135:3795–3801
- . Antibody specificity controls in vivo effector mechanisms of anti-CD20 reagents. Blood. 2004;103:2738–2743
- . Rapid redistribution of CD20 to a low density detergent-insoluble membrane compartment. J Biol Chem. 1998;273:344–348
- . Anti-CD20 monoclonal antibodies—historical and future perspectives. Haematologica. 2010;95:135–143
- Complement-mediated lysis by anti-CD20 mAb correlates with segregation into lipid rafts. Blood. 2003;101:1045–1052
- CD20-induced lymphoma cell death is independent of both caspases and its redistribution into triton X-100 insoluble membrane rafts. Cancer Res. 2003;63:5480–5489
- Homotypic adhesion and lysosome-mediated cell death evoked by anti-CD20 (tositumomab) and HLA DR monoclonal antibodies. J Clin Invest. 2009;119
- . Radiation therapy with tositumomab (B1) anti-CD20 monoclonal antibody initiates extracellular signal-regulated kinase/mitogen-activated protein kinase-dependent cell death that overcomes resistance to apoptosis. Clin Cancer Res. 2008;14:4925–4934
- . Mechanisms of killing by anti-CD20 monoclonal antibodies. Mol Immunol. 2007;44:3823–3837
- . New glycoengineered antibodies with enhanced effector functions. Keystone Symposia Abstract. Antibodies as Drugs. Canada: Whistler, BC; March 27–April 1, 2009;
- . Homodimers but not monomers of Rituxan (chimeric anti-CD20) induce apoptosis in human B-lymphoma cells and synergize with a chemotherapeutic agent and an immunotoxin. Blood. 2001;97:1392–1398
- Properties and structure-function relationships of veltuzumab (hA20), a humanized anti-CD20 monoclonal antibody. Blood. 2009;113:1062–1070
- Complement activation determines the therapeutic activity of rituximab in vivo. J Immunol. 2003;171:1581–1587
- The role of complement in the therapeutic activity of rituximab in a murine B lymphoma model homing in lymph nodes. Haematologica. 2006;91:176–183
- The peritoneal cavity provides a protective niche for B1 and conventional B lymphocytes during anti-CD20 immunotherapy in mice. J Immunol. 2005;174:4389–4399
- Lymphoma depletion during CD20 immunotherapy in mice is mediated by macrophage FcgammaRI, FcgammaRIII, and FcgammaRIV. Blood. 2008;112:1205–1213
- The innate mononuclear phagocyte network depletes B lymphocytes through Fc receptor-dependent mechanisms during anti-CD20 antibody immunotherapy. J Exp Med. 2004;199:1659–1669
- Importance of cellular microenvironment and circulatory dynamics in B cell immunotherapy. J Immunol. 2005;174:817–826
- Type II (tositumomab) anti-CD20 monoclonal antibody out performs type I (rituximab-like) reagents in B-cell depletion regardless of complement activation. Blood. 2008;112:4170–4177
- . Antibody isotype-specific engagement of Fcgamma receptors regulates B lymphocyte depletion during CD20 immunotherapy. J Exp Med. 2006;203:743–753
- . Rituximab-CD20 complexes are shaved from Z138 mantle cell lymphoma cells in intravenous and subcutaneous SCID mouse models. J Immunol. 2007;179:4263–4271
- A polymorphism in the complement component C1qA correlates with prolonged response following rituximab therapy of follicular lymphoma. Clin Cancer Res. 2008;14:6697–6703
- . NK-cell activation and antibody-dependent cellular cytotoxicity induced by rituximab-coated target cells is inhibited by the C3b component of complement. Blood. 2008;111:1456–1463
- Depletion of the C3 component of complement enhances the ability of rituximab-coated target cells to activate human NK cells and improves the efficacy of monoclonal antibody therapy in an in vivo model. Blood. 2009;114:5322–5330
- Transient down-modulation of CD20 by rituximab in patients with chronic lymphocytic leukemia. Blood. 2003;102:3514–3520
- . Intracellular accumulation of the anti-CD20 antibody 1F5 in B-lymphoma cells. Clin Cancer Res. 2002;8:2701–2713
- Monoclonal antibody 1F5 (anti-CD20) serotherapy of human B cell lymphomas. Blood. 1987;69:584–591
- . Apparent modulation of CD20 by rituximab: an alternative explanation. Blood. 2004;103:3989–3990
- Endocytosis and sorting of ErbB2 and the site of action of cancer therapeutics trastuzumab and geldanamycin. Mol Biol Cell. 2004;15:5268–5282
- . Heterogeneity and clinical relevance of the intensity of CD20 and immunoglobulin light-chain expression in B-cell chronic lymphocytic leukemia. Am J Clin Pathol. 1996;106:457–461
- . The shaving reaction: rituximab/CD20 complexes are removed from mantle cell lymphoma and chronic lymphocytic leukemia cells by THP-1 monocytes. J Immunol. 2006;176:2600–2609
- . Rituximab in B-cell chronic lymphocytic leukemia. Semin Oncol. 2003;30:483–492
Supported in part by Leukaemia Research, Cancer Research UK, Association for International Cancer Research, and the Medical Research Council.
PII: S0037-1963(10)00002-8
doi: 10.1053/j.seminhematol.2010.01.001
© 2010 Elsevier Inc. All rights reserved.
« Previous
Next »
Seminars in Hematology
Volume 47, Issue 2
, Pages 107-114
, April 2010
