Seminars in Hematology
Volume 47, Issue 1 , Pages 3-12 , January 2010

Umbilical Cord Blood Transplantation: The First 20 Years

  • John E. Wagner

      Affiliations

    • Division of Hematology/Oncology and Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN
    • Corresponding Author InformationAddress correspondence to John E. Wagner, MD, Box 366 UMHC, University of Minnesota, 420 Delaware St, SE, Minneapolis, MN 55455
  • ,
  • Eliane Gluckman

      Affiliations

    • Eurocord, Hôpital Saint Louis, Paris, France

References 

  1. Copeland EA. Hematopoietic stem cell transplantation. N Engl J Med. 2007;354:1813–1826
  2. Immunomodulation and pharmacological strategies in the treatment of graft-versus-host disease. Exp Opin Pharmacother. 2008;9:2305–2316
  3. Wagner JE, Thompson JS, Carter SL, Kernan NA. Effect of graft-versus-host disease prophylaxis on 3-year disease-free survival in recipients of unrelated donor bone marrow (T-cell depletion trial): a multi-centre, randomized phase II-III trial. Lancet. 2005;366:733–741
  4. Linch DC, Brent L. Can cord blood be used?. [letter] Nature. 1989;340:676
  5. Nathan DG. The beneficence of neonatal hematopoiesis. N Engl J Med. 1989;321:1190–1191
  6. Ende M, Ende N. Hematopoietic transplantation by means of fetal (cord) blood. Virginia Med J. 1972;99:276–280
  7. Koike K. Cryopreservation of pluripotent and committed hemopoietic progenitor cells from human bone marrow and cord blood. Acta Paediatr Jpn. 1983;25:275
  8. Besalduch-Vidal J. Nature and characterization of granulocyte-macrophage precursors in cord blood. Spain: University of Valencia School of Medicine (Doctoral Dissertation); 1985;
  9. Broxmeyer HE. Investigator profile. J Hematother Stem Cell Res. 2000;9:597–605
  10. Boyse EA, Broxmeyer HE, Douglas GW. Preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood. US Patent 5,004,681 issued April 2, 1991 (assigned to Biocyte Corporation).
  11. Broxmeyer HE, Douglas GW, Hangoc G, Cooper S, Bard J, et al. Human umbilical cord blood as a potential source of transplantable hematopoietic stem/progenitor cells. Proc Natl Acad Sci U S A. 1989;86:3828–3832
  12. Broxmeyer HE, et al. Growth characteristics and expansion of human umbilical cord blood and estimation of its potential for transplantation in adults. Proc Natl Acad Sci U S A. 1992;89:4109–4113
  13. Gluckman E, Berger R, Dutreix J. Bone marrow transplantation for Fanconi anemia. Semin Hematol. 1984;21:20–26
  14. Auerbach AD. Umbilical cord blood transplants for genetic disease: diagnostic and ethical issues in fetal studies. Blood Cells. 1994;20:303–309
  15. Gluckman E, Broxmeyer HE, Auerbach AD, et al. Hematopoietic reconstitution in a patient with Fanconi's anemia by means of umbilical cord blood from an HLA-identical sibling. N Engl J Med. 1989;321:1174–1178
  16. Wagner JE, Broxmeyer HE, Byrd RL, et al. Transplantation of umbilical cord blood after myeloablative therapy: analysis of engraftment. Blood. 1992;79:1874–1881
  17. Vilmer E, Sterkers G, Rahimy C, et al. HLA-mismatched cord blood transplantation in a patient with advanced leukemia. Transplantation. 1992;53:1155–1157
  18. Vanlemmens P, Plouvier E, Amsallem D, et al. Transplantation of umbilical cord blood in neuroblastoma. Nouv Rev Fr Hematol. 1992;34:243–246
  19. Kernan NA, Scroeder ML, Ciavarella D, et al. Umbilical cord blood infusion in a patient for correction of Wiskott-Aldrich syndrome. Blood Cells. 1994;20:242–244
  20. Kurtzberg J, Graham M, Casey J, et al. The use of umbilical cord blood in a mismatched related and unrelated hematopoietic stem cell transplantation. Blood Cells. 1994;20:275–284
  21. Pahwa RN, Fleischer A, Than S, et al. Successful hematopoietic reconstitution with transplantation of erythrocyte-depleted allogeneic human umbilical cord blood cells in a child with leukemia. Proc Natl Acad Sci U S A. 1994;91:4485–4488
  22. Bogdanic V, Nemet D, Kastelan A, et al. Umbilical cord blood transplantation in a patient with Philadelphia-chromosome positive chronic myeloid leukemia. Transplantation. 1993;56:477–479
  23. Vowels MR, Lam PO, Tang R, Berdoukas V, et al. Brief report: correction of X-linked lymphoproliferative disease by transplantation of cord-blood stem cells. N Engl J Med. 1993;329:1623–1625
  24. Kohli-Kumar M, Shahidi NT, Broxmeyer HE, et al. Haematopoietic stem/progenitor cell transplant in Fanconi anaemia using HLA-matched sibling umbilical cord blood cells. Br J Haematol. 1993;85:419–422
  25. Issaragrisil S, Visuthisakchai S, Suvatte V, et al. Transplantation of cord blood stem cells into a patient with severe thalassemia. N Engl J Med. 1995;332:367–369
  26. Neudorf SML, Blatt J, Corey S, et al. Graft failure after an umbilical cord blood transplant in a patient with severe aplastic anemia [letter]. Blood. 1995;85:2991–2992
  27. Miniero R, Busca A, Roncarolo MG, et al. HLA haploidentical umbilical cord blood stem cell transplantation in a child with advanced leukemia: clinical outcome and analysis of hematopoietic recovery. Bone Marrow Transplant. 1995;16:229–240
  28. Wagner JE, Kernan NA, Steinbuch M, Broxmeyer HE, Gluckman E. Allogeneic sibling umbilical-cord-blood transplantation in children with malignant and non-malignant disease. Lancet. 1995;346:214–219
  29. Cairo MS, Wagner JE. Review: placental and/or umbilical cord blood: an alternative source of hematopoietic stem cells for transplantation. Blood. 1997;90:4665–4678
  30. Rocha V, Wagner JE, Sobocinski K, Klein JP, Zhang MJ, Horowitz MM, et al. Comparison of graft-versus-host disease in children transplanted with HLA identical sibling umbilical cord blood versus HLA identical sibling bone marrow transplant. N Engl J Med. 2000;342:1846–1854
  31. Rubinstein P, Adamson JW, Stevens C. The placental/umbilical cord blood program of the New York Blood Center: a progress report. Ann NY Acad Sci. 2006;872:328–335
  32. Hackenberg P, Kögler G, Wernet P. NETCORD: a cord blood allocation network. Bone Marrow Transplant. 1998;22:S17–S18
  33. Lazzari L, Corsini C, Curioni C, Lecchi L, Scalamogna M, Rebulla P, et al. The Milan Cord Blood Bank the Italian Cord Blood Network. J Hematother. 1996;5:117–122
  34. Kurtzberg J, Laughlin M, Graham ML, Smith C, Olson JF, Halperin ED, et al. Placental blood as a source of hematopoietic stem cells for transplantation in unrelated recipients. N Engl J Med. 1996;335:157–166
  35. Wagner JE, Rosenthal J, Sweetman R, Shu XO, Davies S, Ramsay NKC, et al. Successful transplantation of HLA-matched and HLA-mismatched umbilical cord blood from unrelated donors: analysis of engraftment and acute graft-versus-host disease. Blood. 1996;88:795–802
  36. Laporte J-P, Gorin N-C, Rubinstein P, Lesage S, Portnoi MF, Barbu V, et al. Cord-blood transplantation from an unrelated donor in an adult with chronic myelogenous leukemia. N Engl J Med. 1996;335:167–170
  37. American Academy of Pediatrics; Working Group on Cord Blood Banking. Cord blood banking for potential future transplantation: subject review. Pediatrics. 1999;104:116–118
  38. Committee on Obstetrical Practice ACoOaG. Routine storage of umbilical cord blood for potential future transplantation. Int J Gynaecol Obstet. 1997;58:257–259
  39. http://parentsguidecordblood.org/content/media/m_pdf/RCOG_opinion2006.pd
  40. Thornley I, Eapen M, Sung L, Lee SJ, Davies SM, Joffe S. Private cord blood banking: experiences and views of pediatric hematopoietic cell transplantation physicians.
  41. International Conference on Cord Blood Transplantation and Biology/Immunology. Indianapolis, Indiana, November 8-11, 1993. Blood Cells. 1994;20:223–269
  42. Wagner JE, Kernan NA, Broxmeyer HE, Gluckman E. Allogeneic umbilical cord blood transplant (Report of results in 26 patients (abstract)). Blood. 1993;82(Suppl 1):86a
  43. Kohn DB, Weinberg KJ, Nolta JA, Heiss LN, Lenarsky C, Crooks GM, et al. Engraftment of gene-modified umbilical cord blood cells in neonates with adenosin deaminase deficiency. Nat Med. 1995;1:1017–1023
  44. Gluckman E, Rocha V, Boyer-Chammard A, Cocatelli F, Arcese W, Pasquini R, et al. Outcome of cord-blood transplantation from related and unrelated donors (Eurocord Transplant Group and the European Blood and Marrow Transplantation Group). N Engl J Med. 1997;337:378–381
  45. Rubinstein P, Carrier C, Scaradavou A, Kurtzberg J, Adamson J, Migliaccio AR, et al. Outcomes amoung 562 recipients of placental-blood transplants for unrelated donors. N Engl J Med. 1998;339:1565–1577
  46. Grewal SS, Kahn JP, MacMillan ML, Ramsay NK, Wagner JE. Successful hematopoietic stem cell transplantation for Fanconi anemia from an unaffected HLA-genotype-identical sibling selected using preimplantation genetic diagnosis. Blood. 2004;103:114–151
  47. Laughlin M, Barker J, Bambach B, Koc ON, Rizzieri DA, Wagner JE, et al. Hematopoietic engraftment and survival in adult recipients of umbilical cord blood from unrelated donors. N Engl J Med. 2001;344:1815–1822
  48. Kogler G, Sensken S, Airey JA, Trapp T, Muschen M, Feldhahn N, et al. A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential. J Exp Med. 2004;200:123–135
  49. Eapen M, Rubinstein P, Zhang MJ, Stevens C, Kurtzberg J, Scaradavou A, et al. Outcomes of transplantation of unrelated donor umbilical cord blood and bone marrow in children with acute leukaemia: a comparison study. Lancet. 2007;369:1947–1954

PII: S0037-1963(09)00142-5

doi: 10.1053/j.seminhematol.2009.10.011

Seminars in Hematology
Volume 47, Issue 1 , Pages 3-12 , January 2010