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Seminars in Hematology
Volume 46, Issue 4
, Pages 387-393
, October 2009
Iron Sequestration and Anemia of Inflammation
References
- . The anemia of infection (I. Hypoferremia, hypercupremia, and alterations in porphyrin metabolism in patients). J Clin Invest. 1946;25:65–80
- . The anemia of infection (II. The experimental production of hypoferremia and anemia in dogs). J Clin Invest. 1946;25:81–86
- . Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS. Blood. 2005;106:1864–1866
- IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest. 2004;113:1271–1276
- . Iron-controlled infection with Neisseria meningitidis in mice. Infect Immun. 1980;29:886–891
- . Inflammation triggers hypoferremia and de novo synthesis of serum transferrin and ceruloplasmin in mice. Infect Immun. 1984;46:489–494
- . Dexamethasone modulation of in vivo effects of endotoxin, tumor necrosis factor, and interleukin-1 on liver cytochrome P-450, plasma fibrinogen, and serum iron. J Leukoc Biol. 1989;46:254–262
- . Correction of the iron overload defect in beta-2-microglobulin knockout mice by lactoferrin abolishes their increased susceptibility to tuberculosis. J Exp Med. 2002;196:1507–1513
- . Enhancement of Neisseria meningitidis infection in mice by addition of iron bound to transferrin. Infect Immun. 1981;34:120–125
- . The role of the reticulo-endothelial cell in iron metabolism. Br J Haematol. 1960;6:43–55
- . Storage iron kinetics (VII. A biologic model for reticuloendothelial iron transport). J Clin Invest. 1974;53:1527–1533
- . The anemia of chronic disorders. Semin Hematol. 1966;3:351–375
- . Anemia of the critically ill: “acute” anemia of chronic disease. Crit Care Med. 2000;28:3098–3099
- Hemoglobin levels correlate with interleukin-6 levels in patients with advanced untreated epithelial ovarian cancer: role of inflammation in cancer-related anemia. Blood. 2005;106:362–367
- . Anemia in multiple myeloma. Clin Adv Hematol Oncol. 2004;2:233–241
- . Zinc protoporphyrin in anemia of chronic disorders. Blood. 1993;81:1200–1204
- . Regular low-dose intravenous iron therapy improves response to erythropoietin in haemodialysis patients. Nephrol Dial Transplant. 1996;11:1079–1083
- . Erythropoietin, iron, and erythropoiesis. Blood. 2000;96:823
- Intravenous iron optimizes the response to recombinant human erythropoietin in cancer patients with chemotherapy-related anemia: a multicenter, open-label, randomized trial. J Clin Oncol. 2004;22:1301–1307
- Ferric gluconate reduces epoetin requirements in hemodialysis patients with elevated ferritin. J Am Soc Nephrol. 2008;19:372–379
- Ferric gluconate is highly efficacious in anemic hemodialysis patients with high serum ferritin and low transferrin saturation: results of the Dialysis Patients' Response to IV Iron with Elevated Ferritin (DRIVE) study. J Am Soc Nephrol. 2007;18:975–984
- . Sequential regulation of ferroportin expression after erythrophagocytosis in murine macrophages: early mRNA induction by haem, followed by iron-dependent protein expression. Biochem J. 2008;411:123–131
- Plasma hepcidin levels are elevated but responsive to erythropoietin therapy in renal disease. Kidney Int. 2009;75:976–981
- . Anaemia of rheumatoid arthritis and iron therapy. Ann Rheum Dis. 1965;24:451–457
- . The measurement of reticuloendothelial iron release using iron-dextran. Br J Haematol. 1971;21:617–622
- . Clinical update: intravenous iron for anaemia. Lancet. 2007;369:1502–1504
- . Acute injury with intravenous iron and concerns regarding long-term safety. Clin J Am Soc Nephrol. 2006;1:S19–S23
- . Potential risk for infection and atherosclerosis due to iron therapy. J Ren Nutr. 2005;15:105–110
- . Macrophage iron, hepcidin, and atherosclerotic plaque stability. Exp Biol Med (Maywood). 2007;232:1014–1020
- Disease progression and liver cancer in the ferroportin disease. Gut. 2007;56:1030–1032
- . Iron and liver cancer. Alcohol. 2003;30:145–150
- . Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem. 2001;276:7806–7810
- . Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs. Blood. 2005;106:2196–2199
- Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc Natl Acad Sci U S A. 2001;98:8780–8785
- Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis. Nat Genet. 2003;33:21–22
- Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc Natl Acad Sci U S A. 2002;99:4596–4601
- . Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease. Blood. 2002;100:3776–3781
- Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science. 2004;306:2090–2093
- . A novel mammalian iron-regulated protein involved in intracellular iron metabolism. J Biol Chem. 2000;275:19906–19912
- Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature. 2000;403:776–781
- A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. Mol Cell. 2000;5:299–309
- The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metab. 2005;1:191–200
- . The ferroportin disease. Blood Cells Mol Dis. 2004;32:131–138
- A mutation in the TMPRSS6 gene, encoding a transmembrane serine protease that suppresses hepcidin production, in familial iron deficiency anemia refractory to oral iron. Haematologica. 2008;93:1473–1479
- . Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia. Blood. 2005;105:1797–1802
- . Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation. Blood. 2007;109:4038–4044
- . Hyporesponsiveness to erythropoietin: causes and management. Adv Chronic Kidney Dis. 2009;16:94–100
- Sasu B, Hainu M, Boone TC, Bi XJ, Lee KJ, Arvedson T, et al. Hepcidin, hepcidin antagonists and methods of use. Amgen Inc. Patent 12/022,515. 2009. USA. 1-30-2008.
- The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest. 2002;110:1037–1044
- . Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood. 2003;101:2461–2463
- . Interleukin-6 induces hepcidin expression through STAT3. Blood. 2006;108:3204–3209
- STAT3 is required for IL-6-gp130-dependent activation of hepcidin in vivo. Gastroenterology. 2007;132:294–300
- . STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation. Blood. 2007;109:353–358
- . Isolated microcytic anemia disclosing a unicentric Castleman disease: the interleukin-6/hepcidin pathway?. Eur J Intern Med. 2008;19:367–369
- . Recent advances in immunopathophysiology of interleukin-6: an innovative therapeutic drug, tocilizumab (recombinant humanized anti-human interleukin-6 receptor antibody), unveils the mysterious etiology of immune-mediated inflammatory diseases. Biol Pharmaceut Bull. 2007;30:2001–2006
- . Dysregulated interleukin 6 expression produces a syndrome resembling Castleman's disease in mice. J Clin Invest. 1990;86:592–599
- Anti-interleukin 6 (IL-6) receptor antibody suppresses Castleman's disease like symptoms emerged in IL-6 transgenic mice. Cytokine. 2002;20:304–311
- Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman disease. Blood. 2005;106:2627–2632
- . Anti-interleukin 6 receptor antibody tocilizumab reduces the level of serum hepcidin in patients with multicentric Castleman's disease. Haematologica. 2007;92:857–858
- Involvement of hepcidin in the anemia of multiple myeloma. Clin Cancer Res. 2008;14:3262–3267
- Defective iron supply for erythropoiesis and adequate endogenous erythropoietin production in the anemia associated with systemic-onset juvenile chronic arthritis. Blood. 1996;87:4824–4830
- Hemojuvelin acts as a bone morphogenetic protein co-receptor to regulate hepcidin expression [abstract]. ASH Annual Meeting Abstracts. 2005;106:511
- . Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin. Blood. 2008;111:5195–5204
- . Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6. Proc Natl Acad Sci. 2006;103:10289–10293
- . Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4. Blood. 2007;110:2182–2189
- . Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance. J Clin Invest. 2007;117:1933–1939
- A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell Metab. 2005;2:399–409
- BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism. Nat Genet. 2009;41:482–487
- . Lack of the bone morphogenetic protein BMP6 induces massive iron overload. Nat Genet. 2009;41:478–481
- Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis. Nat Genet. 2004;36:77–82
- . A mouse model of juvenile hemochromatosis. J Clin Invest. 2005;115:2187–2191
- . Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload. J Clin Invest. 2005;115:2180–2186
- Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat Genet. 2006;38:531–539
- . Expression of Rgmc, the murine ortholog of hemojuvelin gene, is modulated by development and inflammation, but not by iron status or erythropoietin. Blood. 2004;104:4308–4310
- . Repression of repulsive guidance molecule C during inflammation is independent of Hfe and involves tumor necrosis factor-alpha. Am J Pathol. 2007;170:497–504
- . Regulation of reticuloendothelial iron transporter MTP1 (Slc11a3) by inflammation. J Biol Chem. 2002;277:39786–39791
- . IRP1 activation by extracellular oxidative stress in the perfused rat liver. J Biol Chem. 2001;276:23192–23196
- . Anemia of chronic disease. N Engl J Med. 2005;352:1011–1023
- . Immunoassay for human serum hepcidin. Blood. 2008;112:4292–4297
Supported in part by Roche Foundation for Anemia Research (RoFAR).
PII: S0037-1963(09)00098-5
doi: 10.1053/j.seminhematol.2009.06.001
© 2009 Elsevier Inc. All rights reserved.
« Previous
Seminars in Hematology
Volume 46, Issue 4
, Pages 387-393
, October 2009
