Seminars in Hematology
Volume 46, Issue 1 , Pages 16-23, January 2009

New Genetic Abnormalities and Treatment Response in Acute Lymphoblastic Leukemia

  • Jules P.P. Meijerink
    • ,
  • Monique L. den Boer
    • ,
  • Rob Pieters

      Affiliations

    • Corresponding Author InformationAddress correspondence to Rob Pieters, MD, PhD, Department of Pediatric Oncology/Hematology, Erasmus Medical Center Rotterdam–Sophia Children's Hospital, Dr Molewaterplein 60, 3015GJ Rotterdam, The Netherlands

Department of Pediatric Oncology/Hematology, Erasmus Medical Center Rotterdam–Sophia Children's Hospital, Rotterdam, The Netherlands

Numerous genetic abnormalities have been identified in acute lymphoblastic leukemia (ALL). Here we review the recurrent abnormalities with emphasis on those recently discovered, and discuss their association with chemotherapy resistance or sensitivity and with clinical response to therapy. Also, the role of genetic abnormalities in leukemogenesis and their potential as therapeutic targets will be discussed.

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PII: S0037-1963(08)00149-2

doi:10.1053/j.seminhematol.2008.09.006

Seminars in Hematology
Volume 46, Issue 1 , Pages 16-23, January 2009

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