« Previous
Next »
Seminars in Hematology
Volume 45, Issue 4
, Pages 218-224
, October 2008
Hematopoietic Stem Cells and the Aging Hematopoietic System
References
- . Age-related changes in lymphocyte development and function. Nat Immunol. 2004;5:133–139
- . Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell. Science. 1996;273:242–245
- . Hematopoiesis: An evolving paradigm for stem cell biology. Cell. 2008;132:631–644
- . Of lineage and legacy: the development of mammalian hematopoietic stem cells. Nat Immunol. 2008;9:129–136
- . Definitive hematopoiesis is autonomously initiated by the AGM region. Cell. 1996;86:897–906
- . Stem cells: Blood lines from embryo to adult. Nature. 2007;446:996–997
- . Cell tracing shows the contribution of the yolk sac to adult haematopoiesis. Nature. 2007;446:1056–1061
- . The purification and characterization of fetal liver hematopoietic stem cells. Proc Natl Acad Sci U S A. 1995;92:10302–10306
- . Characterization of definitive lymphohematopoietic stem cells in the day 9 murine yolk sac. Immunity. 1997;7:335–344
- . Age-associated characteristics of murine hematopoietic stem cells. J Exp Med. 2000;192:1273–1280
- . Hematopoietic stem cell quiescence attenuates DNA damage response and permits DNA damage accumulation during aging. Cell Cycle. 2007;6:2371–2376
- . Hematopoietic stem cells proliferate until after birth and show a reversible phase-specific engraftment defect. J Clin Invest. 2006;116:2808–2816
- A developmental switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cells. Cell. 1990;62:863–874
- . Origin of murine B cell lineages. Annu Rev Immunol. 1993;11:501–538
- . Ontogeny-related changes in proliferative potential of human hematopoietic cells. J Exp Med. 1993;178:787–791
- Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells. Nature. 2004;431:1002–1007
- . Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells. EMBO J. 2004;23:4116–4125
- . Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006;126:663–676
- . Mechanisms of hair graying: Incomplete melanocyte stem cell maintenance in the niche. Science. 2005;307:720–724
- . Effects of telomerase and telomere length on epidermal stem cell behavior. Science. 2005;309:1253–1256
- . Long-term erythropoietic repopulating ability of old, young, and fetal stem cells. J Exp Med. 1983;157:1496–1504
- . Telomerase activity in hematopoietic cells is associated with self-renewal potential. Immunity. 1996;5:207–216
- . Loss of stem cell repopulating ability upon transplantation (Effects of donor age, cell number, and transplantation procedure). J Exp Med. 1982;156:1767–1779
- . Numbers and functions of transplantable primitive immunohematopoietic stem cells (Effects of age). J Immunol. 1989;142:3833–3840
- . Effects of aging on the homing and engraftment of murine hematopoietic stem and progenitor cells. Blood. 2005;106:1479–1487
- . Dynamic changes in mouse hematopoietic stem cell numbers during aging. Blood. 1999;93:3294–3301
- . Genotype-restricted growth and aging patterns in hematopoietic stem cell populations of allophenic mice. J Exp Med. 1990;171:1547–1565
- Upregulation of Flt3 expression within the bone marrow Lin(−)Sca1(+)c-kit(+) stem cell compartment is accompanied by loss of self-renewal capacity. Immunity. 2001;15:659–669
- . Flk-2 is a marker in hematopoietic stem cell differentiation: a simple method to isolate long-term stem cells. Proc Natl Acad Sci U S A. 2001;98:14541–14546
- . SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell. 2005;121:1109–1121
- . Hematopoietic stem cells: The paradigmatic tissue-specific stem cell. Am J Pathol. 2006;169:338–346
- . The aging of hematopoietic stem cells. Nat Med. 1996;2:1011–1016
- Cell intrinsic alterations underlie hematopoietic stem cell aging. Proc Natl Acad Sci U S A. 2005;102:9194–9199
- . Age-dependent increase in side population distribution within hematopoiesis: Implications for our understanding of the mechanism of aging. Stem Cells. 2007;25:828–835
- . Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation. PLoS Biol. 2007;5:e201
- . Major age-related changes of mouse hematopoietic stem/progenitor cells. Ann N Y Acad Sci. 2003;996:195–208
- . The decline in B lymphopoiesis in aged mice reflects loss of very early B-lineage precursors. J Immunol. 2003;171:2326–2330
- . Effects of aging on the common lymphoid progenitor to pro-B cell transition. J Immunol. 2006;176:1007–1012
- . Age-related defects in B lymphopoiesis underlie the myeloid dominance of adult leukemia. Blood. 2007;110:1831–1839
- . Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature. 2007;447:725–729
- Valproic acid stimulates proliferation and self-renewal of hematopoietic stem cells. Cancer Res. 2005;65:2537–2541
- Inhibitors of histone deacetylases promote hematopoietic stem cell self-renewal. Cytotherapy. 2004;6:328–336
- The Polycomb group gene Ezh2 prevents hematopoietic stem cell exhaustion. Blood. 2006;107:2170–2179
- Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature. 2003;423:302–305
- Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1. Immunity. 2004;21:843–851
- . Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature. 2003;425:962–967
- . Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature. 2003;423:255–260
- The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells. Genes Dev. 2007;21:525–530
- . De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells. J Exp Med. 2007;204:715–722
- Late presentation of dyskeratosis congenita as apparently acquired aplastic anaemia due to mutations in telomerase RNA. Lancet. 2003;362:1628–1630
- . Association between aplastic anaemia and mutations in telomerase RNA. Lancet. 2002;359:2168–2170
- Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia. N Engl J Med. 2005;352:1413–1424
- . A telomerase component is defective in the human disease dyskeratosis congenita. Nature. 1999;402:551–555
- Long-term repopulating ability of telomerase-deficient murine hematopoietic stem cells. Blood. 2002;99:2767–2775
- . Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation. Blood. 2003;102:517–520
- . Effect of TERT over-expression on the long-term transplantation capacity of hematopoietic stem cells. Nat Med. 2003;9:369–371
- . Stem cells and their niches. Science. 2006;311:1880–1885
- . Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia. Proc Natl Acad Sci U S A. 2007;104:5431–5436
- . ABC transporters, neural stem cells and neurogenesis—A different perspective. Cell Res. 2006;16:857–871
- Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells. Nature. 2004;431:997–1002
- Foxo3a is essential for maintenance of the hematopoietic stem cell pool. Cell Stem Cell. 2007;1:101–112
- FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell. 2007;128:325–339
- Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells. Nat Med. 2006;12:446–451
- Foxo3 is essential for the regulation of ATM and oxidative stress-mediated homeostasis of hematopoietic stem cells. J Biol Chem. 2008;Epub ahead of print; doi:10:1074/jbc.M800517200
- Hematopoietic dysfunction in a mouse model for Fanconi anemia group D1. Mol Ther. 2006;14:525–535
- . Repopulating defect of mismatch repair-deficient hematopoietic stem cells. Blood. 2003;102:1626–1633
- DNA repair is limiting for haematopoietic stem cells during ageing. Nature. 2007;447:686–690
- Cancer predisposition and hematopoietic failure in Rad50(S/S) mice. Genes Dev. 2002;16:2237–2251
- . Age-related changes in the function of hemopoietic stroma in mice. Exp Hematol. 1998;8:933–936
- . Decline in bone marrow proliferative capacity as a function of age. Blood. 1982;60:245–252
- Increased hematopoietic stem cell mobilization in aged mice. Blood. 2006;108:2190–2197
- A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency. Cell. 2007;129:1097–1110
R.G. was supported by a fellowship from YAD-HANADIV, and D.J.R. was supported by a grant from the National Institutes of Aging, AG029760-02.
PII: S0037-1963(08)00126-1
doi: 10.1053/j.seminhematol.2008.07.010
© 2008 Elsevier Inc. All rights reserved.
« Previous
Next »
Seminars in Hematology
Volume 45, Issue 4
, Pages 218-224
, October 2008
