Seminars in Hematology
Volume 45, Issue 4 , Pages 218-224, October 2008

Hematopoietic Stem Cells and the Aging Hematopoietic System

  • Roi Gazit

      Affiliations

    • Immune Disease Institute, Harvard Stem Cell Institute, and Department of Pathology, Harvard Medical School, Boston, MA
    • ,
  • Irving L. Weissman

      Affiliations

    • Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University Cancer Center, and Department of Pathology, Stanford University School of Medicine, Stanford, CA
    • ,
  • Derrick J. Rossi

      Affiliations

    • Immune Disease Institute, Harvard Stem Cell Institute, and Department of Pathology, Harvard Medical School, Boston, MA
    • Corresponding Author InformationAddress correspondence to Derrick J. Rossi, MD, 200 Longwood Ave, Boston, MA 02115

The etiology of the age-associated pathophysiological changes of the hematopoietic system including the onset of anemia, diminished adaptive immune competence, and myelogenous disease development are underwritten by the loss of normal homeostatic control. As tissue and organ homeostasis in adults is primarily mediated by the activity of stem and progenitor cells, it has been suggested that the imbalances accompanying aging of the hematopoietic system may stem from alterations in the prevalence and/or functional capacity of hematopoietic stem cells (HSCs) and progenitors. In this review, we examine evidence implicating a role for stem cells in the aging of the hematopoietic system, and focus on the mechanisms suggested to contribute to stem cell aging.

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 R.G. was supported by a fellowship from YAD-HANADIV, and D.J.R. was supported by a grant from the National Institutes of Aging, AG029760-02.

PII: S0037-1963(08)00126-1

doi:10.1053/j.seminhematol.2008.07.010

Seminars in Hematology
Volume 45, Issue 4 , Pages 218-224, October 2008

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