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Seminars in Hematology
Volume 45, Issue 4
, Pages 242-249
, October 2008
Anemia of Aging: The Role of Chronic Inflammation and Cancer
References
- . Epidemiology of Anemia in Older Adults. Cambridge, UK: Cambridge University Press; 2008;
- . Impact of anemia on hospitalization and mortality in older adults. Blood. 2006;107:3841–3846
- . Anemia and Functional Decline. New York, NY: Springer; 2007;
- . Anaemia increases the risk of dementia in cognitively intact elderly. Neurobiol Aging. 2006;27:278–284
- Late-life anemia is associated with increased risk of recurrent falls. J Am Geriatr Soc. 2005;53:2106–2111
- Hemoglobin level, chronic kidney disease, and the risks of death and hospitalization in adults with chronic heart failure: The Anemia in Chronic Heart Failure: Outcomes and Resource Utilization (ANCHOR) study. Circulation. 2006;113:2713–2723
- . Blood transfusion in elderly patients with acute myocardial infarction. N Engl J Med. 2001;345:1230–1236
- . Incidence of anemia in older people: An epidemiologic study in a well defined population. J Am Geriatr Soc. 1997;45:825–831
- . Prevalence of anemia in persons 65 years and older in the United States: Evidence for a high rate of unexplained anemia. Blood. 2004;104:2263–2268
- Unexplained anaemia in older persons is characterised by low erythropoietin and low levels of pro-inflammatory markers. Br J Haematol. 2007;136:849–855
- Proinflammatory state and circulating erythropoietin in persons with and without anemia. Am J Med. 2005;118:1288
- Darbepoetin alpha for the treatment of anemia in patients with active cancer not receiving chemotherapy or radiotherapy: Results of a phase III, multicenter, randomized, double-blind, placebo-controlled study. J Clin Oncol. 2008;26:1040–1050
- Phase III trial to evaluate the efficacy of maintaining hemoglobin levels above 12.0 g/dL with erythropoietin vs above 10.0 g/dL without erythropoietin in anemic patients receiving concurrent radiation and cisplatin for cervical cancer. Gynecol Oncol. 2008;108:317–325
- FDA receives new data on risks of anemia drugs. FDA News. 2008;
- . Randomized study of the importance of novel erythropoiesis stimulating protein (Aranesp) for the effect of radiotherapy in patients with primary squamous cell carcinoma of the head and neck (HNSCC) (The Danish Head and Neck Cancer Group DAHNCA 10 rand). Eur J Cancer suppl. 2007;5:7;(abstr 6LB)
- Randomized, double-blind, placebo-controlled trial of erythropoietin in non-small-cell lung cancer with disease-related anemia. J Clin Oncol. 2007;25:1027–1032
- Maintaining normal hemoglobin levels with epoetin alfa in mainly nonanemic patients with metastatic breast cancer receiving first-line chemotherapy: A survival study. J Clin Oncol. 2005;23:5960–5972
- Darbepoetin Alfa 20000161 Study Group (Efficacy and safety of darbepoetin alfa in anaemic patients with lymphoproliferative malignancies: A randomized, double-blind, placebo-controlled study). Br J Haematol. 2003;122:394–403
- Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy: Randomised, double-blind, placebo-controlled trial. Lancet. 2003;362:1255–1260
- Research agenda for frailty in older adults: Toward a better understanding of physiology and etiology: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults. J Am Geriatr Soc. 2006;54:991–1001
- . The endeavor of high maintenance homeostasis: Resting metabolic rate and the legacy of longevity. J Gerontol A Biol Sci Med Sci. 2006;61:466–471
- . Impact of anemia and cardiovascular disease on frailty status of community-dwelling older women: The Women's Health and Aging Studies I and II. J Gerontol A Biol Sci Med Sci. 2005;60:729–735
- . Anemia in older adults. Curr Opin Hematol. 2005;12:123–128
- . The endocrine system and ageing. J Pathol. 2007;211:173–180
- Low testosterone levels and the risk of anemia in older men and women. Arch Intern Med. 2006;166:1380–1388
- . Anemia in thyroid diseases. Med Clin North Am. 1975;59:1133–1145
- The origins of age-related proinflammatory state. Blood. 2005;105:2294–2299
- The metabolic syndrome, inflammation, and risk of cognitive decline. JAMA. 2004;292:2237–2242
- Inflammatory markers and onset of cardiovascular events: Results from the Health ABC study. Circulation. 2003;108:2317–2322
- . Inflammatory markers and physical performance in older persons: The InCHIANTI study. J Gerontol A Biol Sci Med Sci. 2004;59:242–248
- . Three-year change in inflammatory markers in elderly people and mortality: The Invecchiare in Chianti study. J Am Geriatr Soc. 2007;55:1801–1807
- Serum IL-6 level and the development of disability in older persons. J Am Geriatr Soc. 1999;47:639–646
- . The anemia of chronic disease. J Am Geriatr Soc. 1990;38:1258–1264
- . Mechanisms of disease: Erythropoietin resistance in patients with both heart and kidney failure. Nat Clin Pract Nephrol. 2008;4:47–57
- . Red blood cell physiology in critical illness. Crit Care Med. 2003;31(suppl):S651–S657
- . Anemia in the elderly: Current understanding and emerging concepts. Blood Rev. 2006;20:213–216
- . Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood. 2003;102:783–788
- . IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest. 2004;113:1271–1276
- . Mechanisms of suicidal erythrocyte death. Cell Physiol Biochem. 2005;15:195–202
- . Anemia of inflammation: The hepcidin link. Curr Opin Hematol. 2005;12:107–111
- . Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood. 2003;101:2461–2463
- . Impact of anemia on mortality, cognition, and function in community-dwelling elderly. Am J Med. 2006;119:327–334
- . Anemia status, hemoglobin concentration, and mortality in nursing home older residents. J Am Med Dir Assoc. 2007;8:322–327
- A prospective study of anemia status, hemoglobin concentration, and mortality in an elderly cohort: The Cardiovascular Health Study. Arch Intern Med. 2005;165:2214–2220
- . Cancer and ageing: A nexus at several levels. Nat Rev Cancer. 2005;5:655–662
- . Anemia and Cancer. New York, NY: Springer; 2007;
- . Pretreatment anemia is correlated with the reduced effectiveness of radiation and concurrent chemotherapy in advanced head and neck cancer. Int J Radiat Oncol Biol Phys. 2005;61:1087–1095
- The importance of hemoglobin levels during radiotherapy for carcinoma of the cervix. Cancer. 1999;86:1528–1536
- Predictors of tolerance to chemotherapy in older cancer patients: A prospective pilot study. Eur J Cancer. 2002;38:1466–1473
- . Role of red blood cells in pharmacokinetics of chemotherapeutic agents. Anticancer Drugs. 1999;10:147–153
- Luciani A, Balducci L, Extermann M: Fatigue may be a cause of functional dependence in older cancer patients. Am J Clin Oncol (in press)
- . Fatigue and aging. Crit Rev Oncol Hematol. 2003;48(suppl):S57–S64
- Venous thromboembolism and mortality associated with recombinant erythropoietin and darbepoetin administration for the treatment of cancer-associated anemia. JAMA. 2008;299:914–924
- Impact of cancer-related fatigue on the lives of patients: New findings from the Fatigue Coalition. Oncologist. 2000;5:353–360
- Effect of once-weekly epoetin beta on survival in patients with metastatic breast cancer receiving anthracycline- and/or taxane-based chemotherapy: Results of the Breast Cancer-Anemia and the Value of Erythropoietin (BRAVE) study. J Clin Oncol. 2008;26:592–598
- . Effects of epoetin alfa on hematologic parameters and quality of life in cancer patients receiving nonplatinum chemotherapy: Results of a randomized, double-blind, placebo-controlled trial. J Clin Oncol. 2001;19:2865–2874
- Aranesp 980297 Study Group (Double-blind, placebo-controlled, randomized phase III trial of darbepoetin alfa in lung cancer patients receiving chemotherapy). J Natl Cancer Inst. 2002;94:1211–1220
- Intravenous iron optimizes the response to recombinant human erythropoietin in cancer patients with chemotherapy-related anemia: A multicenter, open-label, randomized trial. J Clin Oncol. 2004;22:1301–1307
- . Iron and Aging. Cambridge, UK: Cambridge University Press; 2008;
- Recombinant human erythropoietins and cancer patients: Updated meta-analysis of 57 studies including 9353 patients. J Natl Cancer Inst. 2006;98:708–714
- Do erythropoietin receptors on cancer cells explain unexpected clinical findings?. J Clin Oncol. 2006;24:4708–4713
- . Erythropoietin: High profile, high scrutiny. J Clin Oncol. 2007;25:1021–1023
- The effect of hemoglobin (hb) level at ESA initiation on outcomes in cancer patients (pts) with chemotherapy-induced anemia (CIA): A patient-based meta-analysis from 6 randomized, placebo-controlled trials (RCTS) of darbepoetin alfa (DA). Blood. 2007;110:3780
- Efficacy and safety analysis of epoetin alfa in patients with small-cell lung cancer: A randomized, double-blind, placebo-controlled trial. J Clin Oncol. 2005;23:9377–9386
- American Society of Clinical Oncology; American Society of Hematology (Use of epoetin and darbepoetin in patients with cancer: 2007 American Society of Clinical Oncology/American Society of Hematology clinical practice guideline update). J Clin Oncol. 2008;26:132–149
PII: S0037-1963(08)00103-0
doi: 10.1053/j.seminhematol.2008.06.001
© 2008 Elsevier Inc. All rights reserved.
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Seminars in Hematology
Volume 45, Issue 4
, Pages 242-249
, October 2008
