Seminars in Hematology
Volume 45 , Pages S16-S20 , April 2008

Platelet Tissue Factor: How Did It Get There and Is It Important?

  • Nigel S. Key

      Affiliations

    • Corresponding Author InformationAddress correspondence to Nigel S. Key, MB ChB FRCP, Harold R. Roberts Professor of Medicine, Director, Harold R Roberts Comprehensive Hemophilia Center, 932 Mary Ellen Jones Building, CB #7035, Chapel Hill, NC 27599.

References 

  1. Falati S, Gross P, Merrill-Skoloff G, Furie BC, Furie B. Real-time in vivo imaging of platelets, tissue factor and fibrin during arterial thrombus formation in the mouse. Nat Med. 2002;8:1175–1181
  2. Hathcock JJ, Nemerson Y. Platelet deposition inhibits tissue factor activity: In vitro clots are impermeable to factor Xa. Blood. 2004;104:123–127
  3. Morrissey JH. Tissue factor: In at the start … and the finish?. J Thromb Haemost. 2003;1:878–880
  4. Gross PL, Furie BC, Merrill-Skoloff G, Chou J, Furie B. Leukocyte-versus microparticle-mediated tissue factor transfer during arteriolar thrombus development. J Leukoc Biol. 2005;78:1318–1326
  5. Day SM, Reeve JL, Pedersen B, Farris DM, Myers DD, Im M, et al. Macrovascular thrombosis is driven by tissue factor derived primarily from the blood vessel wall. Blood. 2005;105:192–198
  6. Chou J, Mackman N, Merrill-Skoloff G, Pedersen B, Furie BC, Furie B. Hematopoietic cell-derived microparticle tissue factor contributes to fibrin formation during thrombus propagation. Blood. 2004;104:3190–3197
  7. Giesen PL, Rauch U, Bohrmann B, Kling D, Roqué M, Fallon JT, et al. Blood-borne tissue factor: Another view of thrombosis. Proc Natl Acad Sci USA. 1999;96:2311–2315
  8. Balasubramanian V, Grabowski E, Bini A, Nemerson Y. Platelets, circulating tissue factor, and fibrin colocalize in ex vivo thrombi: Real-time fluorescence images of thrombus formation and propagation under defined flow conditions. Blood. 2002;100:2787–2792
  9. Rauch U, Bonderman D, Bohrmann B, Badimon JJ, Himber J, Riederer MA, et al. Transfer of tissue factor from leukocytes to platelets is mediated by CD15 and tissue factor. Blood. 2000;96:170–175
  10. Aslam R, Speck ER, Kim M, Crow AR, Bang KW, Nestel FP, et al. Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-alpha production in vivo. Blood. 2006;107:637–641
  11. Del Conde I, Shrimpton CN, Thiagarajan P, López JA. Tissue-factor-bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation. Blood. 2005;106:1604–1611
  12. Falati S, Liu Q, Gross P, Merrill-Skoloff G, Chou J, Vandendries E, et al. Accumulation of tissue factor into developing thrombi in vivo is dependent upon microparticle P-selectin glycoprotein ligand 1 and platelet P-selectin. J Exp Med. 2003;197:1585–1598
  13. Bach R, Jilma B, Mayr F, Johnson G, Long J, Hysjulien J, et al. Time course of tissue factor procoagulant activity increases on mononuclear cells and platelets following endotoxin-induced systemic inflammation in humans. Blood. 2003;102:551a;(abstr)
  14. Breimo ES, Østerud B. Generation of tissue factor-rich microparticles in an ex vivo whole blood model. Blood Coagul Fibrinolysis. 2005;16:399–405
  15. Egorina EM, Sovershaev MA, Olsen JO, Osterud B. Granulocytes do not express but acquire monocyte-derived tissue factor in whole blood: Evidence for a direct transfer. Blood. 2008;111:1208–1216
  16. Maugeri N, Brambilla M, Camera M, Carbone A, Tremoli E, Donati MB, et al. Human polymorphonuclear leukocytes produce and express functional tissue factor upon stimulation. J Thromb Haemost. 2006;4:1323–1330
  17. Osterud B, Rao LV, Olsen JO. Induction of tissue factor expression in whole blood: Lack of evidence for the presence of tissue factor expression in granulocytes. Thromb Haemost. 2000;83:861–867
  18. Zillmann A, Luther T, Müller I, Kotzsch M, Spannagl M, Kauke T, et al. Platelet-associated tissue factor contributes to the collagen-triggered activation of blood coagulation. Biochem Biophys Res Commun. 2001;281:603–609
  19. Leon C, Alex M, Klocke A, Morgenstern E, Moosbauer C, Eckly A, et al. Platelet ADP receptors contribute to the initiation of intravascular coagulation. Blood. 2004;103:594–600
  20. Engelmann B. Initiation of coagulation by tissue factor carriers in blood. Blood Cells Mol Dis. 2006;36:188–190
  21. Halvorsen H, Olsen JO, Osterud B. Granulocytes enhance LPS-induced tissue factor activity in monocytes via an interaction with platelets. J Leukoc Biol. 1993;54:275–282
  22. Østerud B. The role of platelets in decrypting monocyte tissue factor. Dis Mon. 2003;49:7–13
  23. Müller I, Klocke A, Alex M, Kotzsch M, Luther T, Morgenstern E, et al. Intravascular tissue factor initiates coagulation via circulating microvesicles and platelets. FASEB J. 2003;17:476–478
  24. Lopez-Vilchez I, Escolar G, Diaz-Ricart M, Fuste B, Galan AM, White JG. Tissue factor-enriched vesicles are taken up by platelets and induce platelet aggregation in the presence of factor VIIa. Thromb Haemost. 2007;97:202–211
  25. Camera M, Frigerio M, Toschi V, Brambilla M, Rossi F, Cottell DC, et al. Platelet activation induces cell-surface immunoreactive tissue factor expression, which is modulated differently by antiplatelet drugs. Arterioscler Thromb Vasc. 2003;23:1690–1696
  26. Panes O, Matus V, Sáez CG, Quiroga T, Pereira J, Mezzano D. Human platelets synthesize and express functional tissue factor. Blood. 2007;109:5242–5250
  27. Denis MM, Tolley ND, Bunting M, Schwertz H, Jiang H, Lindemann S, et al. Escaping the nuclear confines: signal-dependent pre-mRNA splicing in anucleate platelets. Cell. 2005;122:379–391
  28. Schwertz H, Tolley ND, Foulks JM, Denis MM, Risenmay BW, Buerke M, et al. Signal-dependent splicing of tissue factor pre-mRNA modulates the thrombogenicity of human platelets. J Exp Med. 2006;203:2433–2440
  29. Butenas S, Mann KG. Active tissue factor in blood?. Nat Med. 2004;10:1155–1156
  30. Butenas S, Bouchard BA, Brummel-Ziedins KE, Parhami-Seren B, Mann KG. Tissue factor activity in whole blood. Blood. 2005;105:2764–2770
  31. Goel MS, Diamond SL. Factor VIIa-mediated tenase function on activated platelets under flow. J Thromb Haemost. 2004;2:1402–1410
  32. Hathcock JJ, Nemerson Y. Up against the wall. Blood. 2005;106:1505
  33. Rondina MT, Schwertz H, Harris E, Zimmerman GA, Weyrich AS. Mature tissue factor mRNA is expressed in vivo by platelets isolated from patients with sepsis. Chest. 2006;130:134S;(abstr)
  34. Himber J, Wohlgensinger C, Roux S, Damico LA, Fallon JT, Kirchhofer D, et al. Inhibition of tissue factor limits the growth of venous thrombus in the rabbit. J Thromb Haemost. 2003;1:889–895
  35. Gabriel DA, Li X, Monroe DM, Roberts HR. Recombinant human factor VIIa (rFVIIa) can activate factor FIX on activated platelets. J Thromb Haemost. 2004;2:1816–1822
  36. Monroe DM, Hoffman M, Oliver JA, Roberts HR. Platelet activity of high-dose factor VIIa is independent of tissue factor. Br J Haematol. 1997;99:542–547
  37. Pérez-Pujol S, Aras O, Lozano M, Cocking-Johnson D, Key NS, White JG, et al. Stored platelets contain residual amounts of tissue factor: Evidence from studies on platelet concentrates stored for prolonged periods. Transfusion. 2005;45:572–579
  38. Mackman N, Tilley RE, Key NS. Role of the extrinsic pathway of blood coagulation in hemostasis and thrombosis. Arterioscler Thromb Vasc Biol. 2007;27:1687–1693

 STATEMENT OF CONFLICT OF INTEREST: Nigel Key has received research grants from Novo Nordisk, and has served on advisory boards for Novo Nordisk and Baxter.

PII: S0037-1963(08)00052-8

doi: 10.1053/j.seminhematol.2008.03.012

Seminars in Hematology
Volume 45 , Pages S16-S20 , April 2008