Seminars in Hematology
Volume 45 , Pages S3-S6 , April 2008

Safety Update on Recombinant Factor VIIa in the Treatment of Congenital and Acquired Hemophilia

  • Thomas Abshire

      Affiliations

    • Corresponding Author InformationAddress correspondence to Thomas Abshire, MD, Aflac Cancer Center and Blood Disorders Service, 2015 Uppergate Dr NE, Room 426 A, Emory University, Atlanta, GA 30322.

References 

  1. Abshire T, Kenet G. Recombinant factor VIIa: review of efficacy, dosing regimens and safety in patients with congenital and acquired factor VIII or IX inhibitors. J Thromb Haemost. 2004;2:899–909
  2. Aledort LM. Comparative thrombotic event incidence after infusion of recombinant factor VIIa versus factor VIII inhibitor bypass activity. J Thromb Haemost. 2004;2:1700–1708
  3. O'Connell KA, Wood JJ, Wise RP, Lozier JN, Braun MM. Thromboembolic adverse events after use of recombinant human coagulation factor VIIa. JAMA. 2006;295:293–298
  4. Hoffman M, Monroe DM, Roberts HR. Activated factor VII activates factors IX and X on the surface of activated platelets: Thoughts on the mechanism of action of high-dose activated factor VII. Blood Coagul Fibrinolysis. 1998;9(suppl 1):S61–S65
  5. Roberts HR, Monroe DM, Hoffman M. Safety profile of recombinant factor VIIa. Semin Hematol. 2004;41(suppl 1):101–108
  6. Allen GA, Monroe DM, Roberts HR, Hoffman M. The effect of factor X level on thrombin generation and the procoagulant effect of activated factor VII in a cell-based model of coagulation. Blood Coagul Fibrinolysis. 2000;11(suppl 1):S3–S7
  7. Sallah S, Isaksen M, Seremetis S, Rojkjaer L. Comparative thrombotic event incidence after infusion of recombinant factor VIIa vs. factor VIII inhibitor bypass activity—A rebuttal. J Thromb Haemost. 2005;3:820–822
  8. Hay CR. Thrombosis and recombinant factor VIIa. J Thromb Haemost. 2004;2:1698–1699

 STATEMENT OF CONFLICT OF INTEREST: Thomas Abshire is a member of the advisory board for Novo Nordisk.

PII: S0037-1963(08)00046-2

doi: 10.1053/j.seminhematol.2008.03.006

Seminars in Hematology
Volume 45 , Pages S3-S6 , April 2008

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