Seminars in Hematology
Volume 44, Issue 4 , Pages 267-273 , October 2007

Post-remission Treatment for Adult Patients With Acute Lymphoblastic Leukemia in First Remission: Is There a Role for Autologous Stem Cell Transplantation?

  • Roel Willemze

      Affiliations

    • Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands.
    • Corresponding Author InformationAddress correspondence to Roel Willemze, MD, PhD, Department of Hematology, Leiden University Medical Center, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands.
    • ,
  • Boris Labar

      Affiliations

    • Department of Hematology, University Hospital Center Rebro, Zagreb, Croatia.

References 

  1. Bassan R, Gatta G, Tondini C, Willemze R. Adult acute lymphoblastic leukaemia. Crit Rev Oncol/Hematol. 2004;50:223–261
  2. Goekbuget N, Hoelzer D. Treatment of adult acute lymphoblastic leukemia. ASH Educational Program Book. 2006;133–142
  3. Wassmann B, Pfeifer H, Goekbuget N, Beelen DW, Beck J, Stelljes M, et al. Alternating verus concurrent schedules of imatinib and chemotherapy as front-line therapy for Philadelphia-positive acute lymphoblastic leukemia. Blood. 2006;109:1469–1477
  4. Bruggemann M, Raff T, Flohr T, Goedbuget N, Nakao M, Droese J, et al. Clinical significance of minimal residual disease quantification in adult patients with standard-risk acute lymphoblastic leukemia. Blood. 2006;107:1116–1123
  5. Suciu S, Mandelli F, de Witte T, Zittoun R, Gallo E, Labar B, et al. Allogeneic compared with autologous stem cell transplantation in the treatment of patients younger than 46 years with acute myeloid leukemia (AML) in first complete remission: Intention-to-treat analysis of the EORTC/GIMEMA AML-10 trial. Blood. 2003;102:1232–1240
  6. Yanada M, Matsuo K, Suzuki T, Naoe T. Allogeneic hematopoietic stem cell transplantation as part of postremission therapy improves survival for adult patients with high risk acute lymphoblastic leukemia: A meta-analysis. Cancer. 2006;106:2657–2663
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  9. Hunault M, Harousseau JL, Delain M, Truchan-Graczyk M, Cahn JY, Witz F, et al. Better outcome of adult acute lymphoblastic leukemia after early genoidentical allogeneic bone marrow transplantation (BMT) than after late high dose therapy and autologous BMT: A GOELAMS trial. Blood. 2005;104:3028–3037
  10. Labar B, Suciu S, Zittoun R, Muus P, Marie JP, Peetermans M, et al. Allogeneic stem cell transplantation in acute lymphoblastic leukemia for patients <50 years in first complete remission: Results of the EORTC ALL-3 trial. Haematologica. 2004;89:809–817
  11. Ribera JM, Oriol A, Bethencourt C, Parody R, Hernandez-Rivas JM, Moreno MJ, et al. Comparison of intensive chemotherapy, allogeneic or autologous stem cell transplantation as post-remission treatment for adult patients with high-risk acute lymphoblastic leukemia (Results of the PETHEMA ALL-93 trial). Haematologica. 2005;90:1346–1356
  12. Cornelissen JJ. Current developments in the treatment of acute lymphoblastic leukemia in adults. Bone Marrow Transplant. 2006;37:247
  13. Labar B, Suciu S, Muus P, Willemze R, Marie JP, Fillet G, et al: Stem cell transplantation in adult ALL: A donor versus no donor comparison in the EORTC ALL-4 study. Leuk Res (in press)
  14. Rowe JM, Buck G, Fielding A, Tallman MS, Burnett AK, Chopra R, et al. In adults with standard-risk ALL the greatest benefit is achieved from an allogeneic transplant in first remission and an autologous transplant is less effective than conventional consolidation/maintenance chemotherapy: Final results of the international ALL trial (MRC UKALL XII/ECOG E2993). Blood. 2006;108:5a;(abstr)
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  17. Dhedin N, Dombret H, Thomas X, Lheritier V, Boiron JM, Rigal-Huguet F, et al. Autologous stem cell transplantation in adults with acute lymphoblastic leukemia in first complete remission: Analysis of the LALA-85, -87, -94 trials. Leukemia. 2006;20:336–344
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  19. Rowe JM, Buck G, Burnett AK, Chopra R, Wiernik PH, Richards SM, et al. Induction therapy for adults with acute lymphoblastic leukemia: Results of more than 1500 patients from the international ALL trial: MRC UKALL XII/ECOG E2993. Blood. 2005;106:3760–3767
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  21. Doney K, Buckner CD, Fisher L, Petersen FB, Sanders J, Appelbaum FR, et al. Autologous bone marrow transplantation for acute lymphoblastic leukemia. Bone Marrow Transplant. 1993;12:315–321
  22. Egerer G, Goldschmidt H, Zoz M, Ho AD. Autologous bone marrow transplantation in adult patients with acute lymphoblastic leukemia. Leuk Lymphoma. 2003;44:9–14
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PII: S0037-1963(07)00121-7

doi: 10.1053/j.seminhematol.2007.08.004

Seminars in Hematology
Volume 44, Issue 4 , Pages 267-273 , October 2007

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