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Seminars in Hematology
Volume 44, Issue 2
, Pages 70-76
, April 2007
Hyperhomocysteinemia and Venous Thrombosis
References
- . Metabolic abnormalities detected in a survey of mentally backward individuals in Northern Ireland. Arch Dis Child. 1962;37:505–513
- The natural history of homocystinuria due to cystathionine beta-synthase deficiency. Am J Hum Genet. 1985;37:1–31
- . Homocysteine: Overview of biochemistry, molecular biology, and role in disease processes. Semin Vasc Med. 2005;5:77–86
- . Rapid, fully automated measurement of plasma homocyst(e)ine with the Abbott IMx analyzer. Clin Chem. 1995;41:991–994
- . Clinical implications of plasma homocysteine measurement in cardiovascular disease. ACP Broadsheet No 152: March 1998 J Clin Pathol. 1998;51:183–188
- . An alternative view of homocysteine. Lancet. 1999;354:2072–2074
- Mice deficient in cystathionine beta-synthase: Animal models for mild and severe homocyst(e)inemia. Proc Natl Acad Sci U S A. 1995;92:1585–1589
- . Enhanced susceptibility to arterial thrombosis in a murine model of hyperhomocysteinemia. Blood. 2006;108:2237–2243
- Vascular dysfunction in monkeys with diet-induced hyperhomocyst(e)inemia. J Clin Invest. 1996;98:24–29
- Endothelial dysfunction and elevation of S-adenosylhomocysteine in cystathionine beta-synthase-deficient mice. Circ Res. 2001;88:1203–1209
- . Homocysteine inhibits inactivation of factor Va by activated protein C. J Biol Chem. 2001;276:4389–4397
- . No effect of fasting plasma total homocysteine on protein C activity in vitro. Blood. 2003;101:2446–2447
- . Plasma homocysteine concentration is not associated with activated protein C resistance in patients investigated for hypercoagulability. Thromb Haemost. 2004;91:1115–1122
- Tissue plasminogen activator binding to the annexin II tail domain (Direct modulation by homocysteine). J Biol Chem. 1998;273:9987–9993
- . Modulation of annexin II by homocysteine: Implications for atherothrombosis. J Investig Med. 1998;46:364–369
- . Orchestrating the unfolded protein response in health and disease. J Clin Invest. 2002;110:1389–1398
- . Activation of p38 MAPKinase/cPLA2 pathway in homocysteine-treated platelets. J Thromb Haemost. 2006;4:209–216
- . Effect of homocysteine on platelet activation induced by collagen. Nutrition. 2006;22:69–75
- . Altered platelet reactivity in peripheral vascular disease complicated with elevated plasma homocysteine levels. Atherosclerosis. 2004;175:69–75
- . Homocysteine and atherothrombosis. N Engl J Med. 1998;338:1042–1050
- Homocyst(e)ine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase. J Biol Chem. 1997;272:17012–17017
- . Children with acute lymphoblastic leukaemia have high plasma levels of total homocysteine at time of diagnosis. Scand J Clin Lab Invest. 2006;66:67–78
- . Intermediate homocysteinemia: A thermolabile variant of methylenetetrahydrofolate reductase. Am J Hum Genet. 1988;43:414–421
- A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase. Nat Genet. 1995;10:111–113
- Methylenetetrahydrofolate reductase polymorphism, plasma folate, homocysteine, and risk of myocardial infarction in US physicians. Circulation. 1996;94:2410–2416
- Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation. 1996;93:7–9
- . Prevalence of prothrombin G20210A, factor V G1691A (Leiden), and methylenetetrahydrofolate reductase (MTHFR) C677T in seven different populations determined by multiplex allele-specific PCR. Thromb Haemost. 1999;81:733–738
- . Homocysteine, MTHFR and risk of venous thrombosis: A meta-analysis of published epidemiological studies. J Thromb Haemost. 2005;3:292–299
- Deletion polymorphism in the angiotensin-converting enzyme gene as a thrombophilic risk factor after hip arthroplasty. Thromb Haemost. 1998;80:869–873
- . A single-centre prospective study of clinical and haemostatic risk factors for venous thromboembolism following lower limb arthroplasty. Br J Haematol. 2005;129:87–92
- . Investigation and management of heritable thrombophilia. Br J Haematol. 2001;114:512–528
- . [Plasma homocysteine assay in the exploration of thrombosis in young subjects]. Presse Med. 1991;20:985–988
- . Interrelation of hyperhomocyst(e)inemia, factor V Leiden, and risk of future venous thromboembolism. Circulation. 1997;95:1777–1782
- Hyperhomocysteinemia is a risk factor of recurrent venous thromboembolism. Thromb Haemost. 1998;80:566–569
- Serum homocysteine, thermolabile variant of methylene tetrahydrofolate reductase (MTHFR), and venous thromboembolism: Longitudinal Investigation of Thromboembolism Etiology (LITE). Am J Hematol. 2003;72:192–200
- Homocysteine lowering by B vitamins and the secondary prevention of deep-vein thrombosis and pulmonary embolism (A randomized, placebo-controlled, double blind trial). Blood. 2007;109:139–144
- . Epidemiology of retinal vein occlusion and its association with glaucoma and increased intraocular pressure. Ophthalmologica. 1988;197:69–74
- . Retinal vein occlusion: A form of venous thrombosis or a complication of atherosclerosis? (A meta-analysis of thrombophilic factors). Thromb Haemost. 2005;93:1021–1026
- Hyperhomocysteinemia and the MTHFR C677T mutation in Budd-Chiari syndrome. Am J Hematol. 2002;71:11–14
- Risk factors for thrombophilia in extrahepatic portal vein obstruction. Hepatology. 2005;41:603–608
- Abdominal venous thrombosis in neonates and infants: Role of prothrombotic risk factors - a multicentre case-control study. Br J Haematol. 2000;111:534–539
- . Renal venous thrombosis in neonates: Prothrombotic risk factors and long-term follow-up. Blood. 2004;104:1356–1360
- . Thrombophilic abnormalities, oral contraceptives, and risk of cerebral vein thrombosis: A meta-analysis. Blood. 2006;107:2766–2773
- The 677T genotype of the common MTHFR thermolabile variant and fasting homocysteine in childhood venous thrombosis. Eur J Pediatr. 1999;158(suppl 3):S113–S116
- . Increased fasting total homocysteine plasma levels as a risk factor for thromboembolism in children. Thromb Haemost. 2004;91:308–314
- . Homocysteine and folic acid: Implications for pregnancy. Semin Vasc Med. 2005;5:190–200
- The Hordaland Homocysteine Study: A community-based study of homocysteine, its determinants, and associations with disease. J Nutr. 2006;136:1731S–1740S
- . Changes in haemostasis during normal pregnancy: Does homocysteine play a role in maintaining homeostasis?. Proc Nutr Soc. 2003;62:479–493
- Factor V Leiden, prothrombin 20210G→A, methylenetetrahydrofolate reductase 677C→T and plasminogen activator inhibitor 4G/5G polymorphism in women with pregnancy-related venous thromboembolism. Eur J Obstet Gynecol Reprod Biol. 2003;111:157–163
- . Association between inherited thrombophilias, antiphospholipid antibodies, and lipoprotein A levels and venous thromboembolism in pregnancy. Am J Perinatol. 2003;20:17–24
- Screening for thrombophilia in high-risk situations: Systematic review and cost-effectiveness analysis (The Thrombosis Risk and Economic Assessment of Thrombophilia Screening (TREATS) study). Health Technol Assess. 2006;10:1–110
- . Homocystinuria due to cystathionine beta-synthase deficiency in Ireland: 25 years’ experience of a newborn screened and treated population with reference to clinical outcome and biochemical control. J Inherit Metab Dis. 1998;21:738–747
- Vascular outcome in patients with homocystinuria due to cystathionine beta-synthase deficiency treated chronically: A multicenter observational study. Arterioscler Thromb Vasc Biol. 2001;21:2080–2085
- . Lowering blood homocysteine with folic acid based supplements: Meta-analysis of randomised trials. BMJ. 1998;316:894–898
- Endothelial dysfunction in a murine model of mild hyperhomocyst(e)inemia. J Clin Invest. 2000;106:483–491
- Long-term improvement in homocysteine levels and arterial endothelial function after 1-year folic acid supplementation. Am J Med. 2002;112:535–539
- Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: The Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial. JAMA. 2004;291:565–575
- Homocysteine lowering with folic acid and B vitamins in vascular disease. N Engl J Med. 2006;354:1567–1577
- . Women’s Health Initiative (WHI) Dietary Trial and Norwegian Vitamin Trial (NORVIT). Prev Cardiol. 2006;9:178–182
PII: S0037-1963(07)00003-0
doi: 10.1053/j.seminhematol.2007.01.002
© 2007 Elsevier Inc. All rights reserved.
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Seminars in Hematology
Volume 44, Issue 2
, Pages 70-76
, April 2007
