Seminars in Hematology
Volume 44, Issue 1 , Pages 2-14 , January 2007

Pulmonary Transfusion Reactions

  • David F. Stroncek

      Affiliations

    • Corresponding Author InformationAddress correspondence to David F. Stroncek, MD, Department of Transfusion Medicine, National Institutes of Health, Warren G. Magnuson Clinical Center, Building 10, Room 1C711, 10 Center Dr, MSC-1184, Bethesda, MD, 20892-1184.

References 

  1. Dodd RY, Notari EP, Stramer SL. Current prevalence and incidence of infectious disease markers and estimated window-period risk in the American Red Cross blood donor population. Transfusion. 2002;42:975–979
  2. Enright H, Davis K, Gernsheimer T, McCullough JJ, Woodson R, Slichter SJ. Factors influencing moderate to severe reactions to PLT transfusions: experience of the TRAP multicenter clinical trial. Transfusion. 2003;43:1545–1552
  3. Goldman M, Webert KE, Arnold DM, Freedman J, Hannon J, Blajchman MA. Proceedings of a consensus conference: towards an understanding of TRALI. Transfus Med Rev. 2005;19:2–31
  4. Popovsky MA. Breathlessness and blood: A combustible combination. Vox Sang. 2002;83(suppl):147–150
  5. Popovsky MA, Audet AM, Andrzejewski C. Transfusion-associated circulatory overload in orthopedic surgery patients: A multi-institutional study. Immunohematol. 1996;12:87–89
  6. Maisel AS, Krishnaswamy P, Nowak RM, McCord J, Hollander JE, Duc P, et al. Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure. N Engl J Med. 2002;347:161–167
  7. Zhou L, Giacherio D, Cooling L, Davenport RD. Use of B-natriuretic peptide as a diagnostic marker in the differential diagnosis of transfusion-associated circulatory overload. Transfusion. 2005;45:1056–1063
  8. Burgher AH, Aslan D, Laudi N, Bowman RJ. Use of brain natriuretic peptide to evaluate transfusion-related acute lung injury. Transfusion. 2004;44:1533–1534
  9. Vassallo RR. Review: IgA anaphylactic transfusion reactions (Part I. Laboratory diagnosis, incidence, and supply of IgA-deficient products). Immunohematol. 2004;20:226–233
  10. Sandler SG, Eckrich R, Malamut D, Mallory D. Hemagglutination assays for the diagnosis and prevention of IgA anaphylactic transfusion reactions. Blood. 1994;84:2031–2035
  11. Sandler SG, Zantek ND. Review: IgA anaphylactic transfusion reactions (Part II. Clinical diagnosis and bedside management). Immunohematol. 2004;20:234–238
  12. Salama A, Temmesfeld B, Hippenstiel S, Kalus U, Suttorp N, Kiesewetter H. A new strategy for the prevention of IgA anaphylactic transfusion reactions. Transfusion. 2004;44:509–511
  13. Koda Y, Watanabe Y, Soejima M, Shimada E, Nishimura M, Morishita K, et al. Simple PCR detection of haptoglobin gene deletion in anhaptoglobinemic patients with antihaptoglobin antibody that causes anaphylactic transfusion reactions. Blood. 2000;95:1138–1143
  14. Michel J, Sharon R. Non-haemolytic adverse reaction after transfusion of a blood unit containing penicillin. Br Med J. 1980;280:152–153
  15. Sharon R, Kidroni G, Michel J. Presence of aspirin in blood units. Vox Sang. 1980;38:284–287
  16. Branch DR, Gifford H. Allergic reaction to transfused cephalothin antibody. JAMA. 1979;241:495–496
  17. Red blood cell transfusions contaminated with Yersinia enterocolitica—United States, 1991-1996, and initiation of a national study to detect bacteria-associated transfusion reactions. MMWR Morb Mortal Wkly Rep. 1997;46:553–555
  18. Stevens WT, Bolan CD, Oblitas JM, Stroncek DF, Bennett JE, Leitman SF. Streptococcus agalactiae sepsis after transfusion of a plateletpheresis concentrate: Benefit of donor evaluation. Transfusion. 2006;46:649–651
  19. Haimowitz MD, Hernandez LA, Herron RM. A blood donor with bacteraemia. Lancet. 2005;365:1596
  20. Rhame FS, Root RK, MacLowry JD, Dadisman TA, Bennett JV. Salmonella septicemia from platelet transfusions (Study of an outbreak traced to a hematogenous carrier of Salmonella cholerae-suis). Ann Intern Med. 1973;78:633–641
  21. Jafari M, Forsberg J, Gilcher RO, Smith JW, Crutcher JM, McDermott M, et al. Salmonella sepsis caused by a platelet transfusion from a donor with a pet snake. N Engl J Med. 2002;347:1075–1078
  22. Heal JM, Singal S, Sardisco E, Mayer T. Bacterial proliferation in platelet concentrates. Transfusion. 1986;26:388–390
  23. Klein HG. Pathogen inactivation technology: cleansing the blood supply. J Intern Med. 2005;257:224–237
  24. Buchholz DH, AuBuchon JP, Snyder EL, Kandler R, Edberg S, Piscitelli V, et al. Removal of Yersinia enterocolitica from AS-1 red cells. Transfusion. 1992;32:667–672
  25. Wortham ST, Ortolano GA, Wenz B. A brief history of blood filtration: Clot screens, microaggregate removal, and leukocyte reduction. Transfus Med Rev. 2003;17:216–222
  26. Leclercq A, Martin L, Vergnes ML, Ounnoughene N, Laran JF, Giraud P, et al. Fatal Yersinia enterocolitica biotype 4 serovar O:3 sepsis after red blood cell transfusion. Transfusion. 2005;45:814–818
  27. Webster BH. Clinical presentation of haemolytic transfusion reactions. Anaesth Intensive Care. 1980;8:115–119
  28. Barjas-Castro ML, Locatelli MF, Carvalho MA, Gilli SO, Castro V. Severe immune haemolysis in a group A recipient of a group O red blood cell unit. Transfus Med. 2003;13:239–241
  29. Stroncek DF, Shapiro RS, Filipovich AH, Plachta LB, Clay ME. Prolonged neutropenia resulting from antibodies to neutrophil-specific antigen NB1 following marrow transplantation. Transfusion. 1993;33:158–163
  30. Stroncek DF, Leonard K, Eiber G, Malech HL, Gallin JI, Leitman SF. Alloimmunization after granulocyte transfusions. Transfusion. 1996;36:1009–1015
  31. Sachs UJ, Bux J. TRALI after the transfusion of cross-match-positive granulocytes. Transfusion. 2003;43:1683–1686
  32. McCullough J, Clay M, Hurd D, Richards K, Ludvigsen C, Forstrom L. Effect of leukocyte antibodies and HLA matching on the intravascular recovery, survival, and tissue localization of 111-indium granulocytes. Blood. 1986;67:522–528
  33. Wright DG, Robichaud KJ, Pizzo PA, Deisseroth AB. Lethal pulmonary reactions associated with the combined use of amphotericin B and leukocyte transfusions. N Engl J Med. 1981;304:1185–1189
  34. Swank RL. Alteration of blood on storage: measurement of adhesiveness of “aging” platelets and leukocytes and their removal by filtration. N Engl J Med. 1961;265:728–733
  35. Reul GJ, Beall AC, Greenberg SD. Protection of the pulmonary microvasculature by fine screen blood filtration. Chest. 1974;66:4–9
  36. Collins JA, James PM, Bredenberg CE, Anderson RW, Heisterkamp CA, Simmons RL. The relationship between transfusion and hypoxemia in combat casualties. Ann Surg. 1978;188:513–520
  37. Tobey RE, Kopriva CJ, Homer LD, Solis RT, Dickson LG, Herman CM. Pulmonary gas exchange following hemorrhagic shock and massive blood transfusion in the baboon. Ann Surg. 1974;179:316–321
  38. Hillyer CD, Roback JD, Hillyer KL, Josephson CD, Page PL. Description and investigation of white particulate matter in additive solution-1 red blood cell units. Transfusion. 2004;44:977–983
  39. Patel HD, Byrne KM, Horne M, Leitman SF, Stroncek DF. Factors affecting the formation of white particulate matter in red blood cell components. Transfusion. 2005;45:1127–1132
  40. Hudson LD, Milberg JA, Anardi D, Maunder RJ. Clinical risks for development of the acute respiratory distress syndrome. Am J Respir Crit Care Med. 1995;151:293–301
  41. Fowler AA, Hamman RF, Good JT, Benson KN, Baird M, Eberle DJ, et al. Adult respiratory distress syndrome: risk with common predispositions. Ann Intern Med. 1983;98:593–597
  42. Miller PR, Croce MA, Kilgo PD, Scott J, Fabian TC. Acute respiratory distress syndrome in blunt trauma: identification of independent risk factors. Am Surg. 2002;68:845–850
  43. Larson CP. Venous air embolism; report of four cases; suggested method of treatment. Am J Clin Pathol. 1951;21:247–250
  44. Crehan JP, Nicholson MJ. Emergency treatment of air embolism. Curr Res Anesth Analg. 1956;35:634–643
  45. Schmidt PJ, Kevy SV. Air embolism; a hazard during phlebotomy. N Engl J Med. 1958;258:424–427
  46. Walter CW, Murphy WP. A closed gravity technique for the preservation of whole blood in ACD solution utilizing plastic equipment. Surg Gynecol Obstet. 1952;94:687–692
  47. Barnard RD. Indiscriminate transfusion: A critique of case reports illustrating hypersensitivity reactions. N Y State J Med. 1951;51:2399–2402
  48. Gould DM, Torrance DJ. Pulmonary edema. Am J Roentgenol Radium Ther Nucl Med. 1955;73:366–374
  49. Brittingham TE. Immunologic studies on leukocytes. Vox Sang. 1957;2:242–248
  50. Philipps E, Fleischner FG. Pulomonary edema in the course of a blood transfusion without overloading the circulation. Dis Chest. 1966;50:619–623
  51. Ward HN, Lipscomb TS, Cawley LP. Pulmonary hypersensitivity reaction after blood transfusion. Arch Intern Med. 1968;122:362–366
  52. Ward HN. Pulmonary infiltrates associated with leukoagglutinin transfusion reactions. Ann Intern Med. 1970;73:689–694
  53. Thompson JS, Severson CD, Parmely MJ, Marmorstein BL, Simmons A. Pulmonary “hypersensitivity” reactions induced by transfusion of non-HL-A leukoagglutinins. N Engl J Med. 1971;284:1120–1125
  54. Andrews AT, Zmijewski CM, Bowman HS, Reihart JK. Transfusion reaction with pulmonary infiltration associated with HL-A-specific leukocyte antibodies. Am J Clin Pathol. 1976;66:483–487
  55. Popovsky MA, Abel MD, Moore SB. Transfusion-related acute lung injury associated with passive transfer of antileukocyte antibodies. Am Rev Respir Dis. 1983;128:185–189
  56. Popovsky MA, Moore SB. Diagnostic and pathogenetic considerations in transfusion-related acute lung injury. Transfusion. 1985;25:573–577
  57. Wallis JP, Lubenko A, Wells AW, Chapman CE. Single hospital experience of TRALI. Transfusion. 2003;43:1053–1059
  58. Popovsky MA, Haley NR. Further characterization of transfusion-related acute lung injury: Demographics, clinical and laboratory features, and morbidity. Immunohematol. 2001;17:157–159
  59. Densmore TL, Goodnough LT, Ali S, Dynis M, Chaplin H. Prevalence of HLA sensitization in female apheresis donors. Transfusion. 1999;39:103–106
  60. Silliman CC, Boshkov LK, Mehdizadehkashi Z, Elzi DJ, Dickey WO, Podlosky L, et al. Transfusion-related acute lung injury: Epidemiology and a prospective analysis of etiologic factors. Blood. 2003;101:454–462
  61. Palfi M, Berg S, Ernerudh J, Berlin G. A randomized controlled trial oftransfusion-related acute lung injury: Is plasma from multiparous blood donors dangerous?. Transfusion. 2001;41:317–322
  62. Gong MN, Thompson BT, Williams P, Pothier L, Boyce PD, Christiani DC. Clinical predictors of and mortality in acute respiratory distress syndrome: Potential role of red cell transfusion. Crit Care Med. 2005;33:1191–1198
  63. Croce MA, Tolley EA, Claridge JA, Fabian TC. Transfusions result in pulmonary morbidity and death after a moderate degree of injury. J Trauma. 2005;59:19–23
  64. Dara SI, Rana R, Afessa B, Moore SB, Gajic O. Fresh frozen plasma transfusion in critically ill medical patients with coagulopathy. Crit Care Med. 2005;33:2667–2671
  65. Craddock PR, Fehr J, Brigham KL, Kronenberg RS, Jacob HS. Complement and leukocyte-mediated pulmonary dysfunction in hemodialysis. N Engl J Med. 1977;296:769–774
  66. Craddock PR, Fehr J, Dalmasso AP, Brighan KL, Jacob HS. Hemodialysis leukopenia (Pulmonary vascular leukostasis resulting from complement activation by dialyzer cellophane membranes). J Clin Invest. 1977;59:879–888
  67. Abraham E. Neutrophils and acute lung injury. Crit Care Med. 2003;31:S195–S199
  68. Nakagawa M, Toy P. Acute and transient decrease in neutrophil count in transfusion-related acute lung injury: Cases at one hospital. Transfusion. 2004;44:1689–1694
  69. Marques MB, Tuncer HH, Divers SG, Baker AC, Harrison DK. Acute transient leukopenia as a sign of TRALI. Am J Hematol. 2005;80:90–91
  70. Yomtovian R, Kline W, Press C, Clay M, Engman H, Hammerschmidt D, et al. Severe pulmonary hypersensitivity associated with passive transfusion of a neutrophil-specific antibody. Lancet. 1984;1:244–246
  71. Leger R, Palm S, Wulf H, Vosberg A, Neppert J. Transfusion-related lung injury with leukopenic reaction caused by fresh frozen plasma containing anti-NB1. Anesthesiology. 1999;91:1529–1532
  72. Bux J, Becker F, Seeger W, Kilpatrick D, Chapman J, Waters A. Transfusion-related acute lung injury due to HLA-A2-specific antibodies in recipient and NB1-specific antibodies in donor blood. Br J Haematol. 1996;93:707–713
  73. Kopko PM, Marshall CS, MacKenzie MR, Holland PV, Popovsky MA. Transfusion-related acute lung injury: report of a clinical look-back investigation. JAMA. 2002;287:1968–1971
  74. Davoren A, Curtis BR, Shulman IA, Mohrbacher AF, Bux J, Kwiatkowska BJ, et al. TRALI due to granulocyte-agglutinating human neutrophil antigen-3a (5b) alloantibodies in donor plasma: A report of 2 fatalities. Transfusion. 2003;43:641–645
  75. Nordhagen R, Conradi M, Dromtorp SM. Pulmonary reaction associated with transfusion of plasma containing anti-5b. Vox Sang. 1986;51:102–107
  76. Seeger W, Schneider U, Kreusler B, von Witzleben E, Walmrath D, Grimminger F, et al. Reproduction of transfusion-related acute lung injury in an ex vivo lung model. Blood. 1990;76:1438–1444
  77. Sachs UJ, Hattar K, Weissmann N, Bohle RM, Weiss T, Sibelius U, et al. Antibody-induced neutrophil activation as a trigger for transfusion-related acute lung injury in an ex vivo rat lung model. Blood. 2006;107:1217–1219
  78. Nicolle AL, Chapman CE, Carter V, Wallis JP. Transfusion-related acute lung injury caused by two donors with anti-human leucocyte antigen class II antibodies: A look-back investigation. Transfus Med. 2004;14:225–230
  79. Fontaine MJ, Malone J, Mullins FM, Grument FC. Diagnosis of transfusion-related acute lung injury: TRALI or not TRALI?. Ann Clin Lab Sci. 2006;36:53–58
  80. Toy P, Hollis-Perry KM, Jun J, Nakagawa M. Recipients of blood from a donor with multiple HLA antibodies: A lookback study of transfusion-related acute lung injury. Transfusion. 2004;44:1683–1688
  81. Silliman CC, Clay KL, Thurman GW, Johnson CA, Ambruso DR. Partial characterization of lipids that develop during the routine storage of blood and prime the neutrophil NADPH oxidase. J Lab Clin Med. 1994;124:684–694
  82. Silliman CC, Dickey WO, Paterson AJ, Thurman GW, Clay KL, Johnson CA, et al. Analysis of the priming activity of lipids generated during routine storage of platelet concentrates. Transfusion. 1996;36:133–139
  83. Wyman TH, Bjornsen AJ, Elzi DJ, Smith CW, England KM, Kelher M, et al. A two-insult in vitro model of PMN-mediated pulmonary endothelial damage: Requirements for adherence and chemokine release. Am J Physiol Cell Physiol. 2002;283:C1592–C1603
  84. Silliman CC, Bjornsen AJ, Wyman TH, Kelher M, Allard J, Bieber S, et al. Plasma and lipids from stored platelets cause acute lung injury in an animal model. Transfusion. 2003;43:633–640
  85. Silliman CC, Voelkel NF, Allard JD, Elzi DJ, Tuder RM, Johnson JL, et al. Plasma and lipids from stored packed red blood cells cause acute lung injury in an animal model. J Clin Invest. 1998;101:1458–1467
  86. Silliman CC, Paterson AJ, Dickey WO, Stroneck DF, Popovsky MA, Caldwell SA, et al. The association of biologically active lipids with the development of transfusion-related acute lung injury: A retrospective study. Transfusion. 1997;37:719–726
  87. Silliman CC, McLaughlin NJ. Transfusion-related acute lung injury. Blood Rev. 2006;20:139–159
  88. Adawi A, Zhang Y, Baggs R, Rubin P, Williams J, Finkelstein J, et al. Blockade of CD40-CD40 ligand interactions protects against radiation-induced pulmonary inflammation and fibrosis. Clin Immunol Immunopathol. 1998;89:222–230
  89. Moore TM, Shirah WB, Khimenko PL, Paisley P, Lausch RN, Taylor AE. Involvement of CD40-CD40L signaling in postischemic lung injury. Am J Physiol Lung Cell Mol Physiol. 2002;283:L1255–L1262
  90. Medford AR, Keen LJ, Bidwell JL, Millar AB. Vascular endothelial growth factor gene polymorphism and acute respiratory distress syndrome. Thorax. 2005;60:244–248
  91. Marshall RP, Webb S, Bellingan GJ, Montgomery HE, Chaudhari B, McAnulty RJ, et al. Angiotensin converting enzyme insertion/deletion polymorphism is associated with susceptibility and outcome in acute respiratory distress syndrome. Am J Respir Crit Care Med. 2002;166:646–650
  92. Gong MN, Zhou W, Williams PL, Thompson BT, Pothier L, Boyce P, et al. -308GA and TNFB polymorphisms in acute respiratory distress syndrome. Eur Respir J. 2005;26:382–389
  93. Popovsky MA, Chaplin HC, Moore SB. Transfusion-related acute lung injury: A neglected, serious complication of hemotherapy. Transfusion. 1992;32:589–592
  94. Toy P, Popovsky MA, Abraham E, Ambruso DR, Holness LG, Kopko PM, et al. Transfusion-related acute lung injury: Definition and review. Crit Care Med. 2005;33:721–726
  95. In: Standards for Blood Banks and Transfusion Services. (ed 23). Bethesda, MD: AABB; 2004;
  96. Kline WE, Press C, Clay M, Keashen-Schnell M, Hackel E, McCullough J. Three sera defining a new granulocyte-monocyte-T-lymphocyte antigen. Vox Sang. 1986;50:181–186
  97. Bux J, Jung KD, Mueller-Eckhardt G, Mueller-Eckhardt C. [Granulocyte-specific and HLA antibodies in pregnancy: Incidence and clinical value]. Beitr Infusionsther. 1992;30:446–449
  98. Murphy S. Platelets from pooled buffy coats: an update. Transfusion. 2005;45:634–639

PII: S0037-1963(06)00236-8

doi: 10.1053/j.seminhematol.2006.09.014

Seminars in Hematology
Volume 44, Issue 1 , Pages 2-14 , January 2007