Seminars in Hematology
Volume 43 , Pages S18-S22 , October 2006

Intravenous Iron in Inflammatory Bowel Disease

  • Christoph Gasche

      Affiliations

    • Corresponding Author InformationAddress correspondence to Christoph Gasche, MD, Medical University of Vienna, Department of Internal Medicine IV, Division of Gastroenterology and Hepatology, Währinger Gürtel 18-20, A-1090 Vienna, Austria.
  • ,
  • Stefanie Kulnigg

References 

  1. Cho JH, Nicolae DL, Gold LH, Fields CT, LaBuda MC, Rohal PM, et al. Identification of novel susceptibility loci for inflammatory bowel disease on chromosomes 1p, 3q, and 4q: Evidence for epistasis between 1p and IBD1. Proc Natl Acad Sci U S A. 1998;95:7502–7507
  2. Hugot JP, Chamaillard M, Zouali H, Lesage S, Cezard JP, Belaiche J, et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn’s disease. Nature. 2001;411:599–603
  3. Gasche C, Grundtner P. Genotypes and phenotypes in Crohn’s disease: Do they help in clinical management?. Gut. 2005;54:162–167
  4. Dalziel TK. Chronic interstitial enteritis. Br Med J. 1913;2:1068
  5. Moum B, Ekbom A. Epidemiology of inflammatory bowel disease—Methodological considerations. Dig Liver Dis. 2002;34:364–369
  6. Blanchard JF, Bernstein CN, Wajda A, Rawsthorne P. Small-area variations and sociodemographic correlates for the incidence of Crohn’s disease and ulcerative colitis. Am J Epidemiol. 2001;154:328–335
  7. Cosnes J, Carbonnel F, Beaugerie L, Le Quintrec Y, Gendre JP. Effects of cigarette smoking on the long-term course of Crohn’s disease. Gastroenterology. 1996;110:424–431
  8. Sandborn WJ, Tremaine WJ, Offord KP, Lawson GM, Petersen BT, Batts KP, et al. Transdermal nicotine for mildly to moderately active ulcerative colitis (A randomized, double-blind, placebo-controlled trial). Ann Intern Med. 1997;126:364–371
  9. Best WR, Becktel JM, Singleton JW, Kern FJ. Development of a Crohn’s disease activity index (National Cooperative Crohn’s Disease Study). Gastroenterology. 1976;70:439–444
  10. Truelove SC, Witts LJ. Cortisone in ulcerative colitis: Final report on a therapeutic trial. Br Med J. 1955;4947:1041–1048
  11. Gasche C. Anemia in IBD: The overlooked villain. Inflamm Bowel Dis. 2000;6:142–150
  12. Yates P, Macht LM, Williams NA, Elson CJ. Red cell autoantibody production by colonic mononuclear cells from a patient with ulcerative colitis and autoimmune haemolytic anaemia. Br J Haematol. 1992;82:753–756
  13. Hansen TM, Hansen NE, Birgens HS, Holund B, Lorenzen I. Serum ferritin and the assessment of iron deficiency in rheumatoid arthritis. Scand J Rheumatol. 1983;12:353–359
  14. Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med. 2005;352:1011–1023
  15. Gasche C, Reinisch W, Lochs H, Parsaei B, Bakos S, Wyatt J, et al. Anemia in Crohn’s disease (Importance of inadequate erythropoietin production and iron deficiency). Dig Dis Sci. 1994;39:1930–1934
  16. Ganz T. Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood. 2003;102:783–788
  17. Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science. 2004;306:2090–2093
  18. Babbs CF. Oxygen radicals in ulcerative colitis. Free Radic Biol Med. 1992;13:169–181
  19. Erichsen K, Hausken T, Ulvik RJ, Svardal A, Berstad A, Berge RK. Ferrous fumarate deteriorated plasma antioxidant status in patients with Crohn disease. Scand J Gastroenterol. 2003;38:543–548
  20. De Silva AD, Tsironi E, Feakins RM, Rampton DS. Efficacy and tolerability of oral iron therapy in inflammatory bowel disease: A prospective, comparative trial. Aliment Pharmacol Ther. 2005;22:1097–1105
  21. Erichsen K, Milde AM, Arslan G, Helgeland L, Gudbrandsen OA, Ulvik RJ, et al. Low-dose oral ferrous fumarate aggravated intestinal inflammation in rats with DSS-induced colitis. Inflamm Bowel Dis. 2005;11:744–748
  22. Oldenburg B, Berge Henegouwen GP, Rennick D, Van Asbeck BS, Koningsberger JC. Iron supplementation affects the production of pro-inflammatory cytokines in IL-10 deficient mice. Eur J Clin Invest. 2000;30:505–510
  23. Carrier J, Aghdassi E, Platt I, Cullen J, Allard JP. Effect of oral iron supplementation on oxidative stress and colonic inflammation in rats with induced colitis. Aliment Pharmacol Ther. 2001;15:1989–1999
  24. Carrier J, Aghdassi E, Cullen J, Allard JP. Iron supplementation increases disease activity and vitamin E ameliorates the effect in rats with dextran sulfate sodium-induced colitis. J Nutr. 2002;132:3146–3150
  25. Carrier JC, Aghdassi E, Jeejeebhoy K, Allard JP. Exacerbation of dextran sulfate sodium-induced colitis by dietary iron supplementation: role of NF-kappaB. Int J Colorectal Dis. 2006;21:381–387
  26. Gasche C, Lomer MC, Cavill I, Weiss G. Iron, anaemia, and inflammatory bowel diseases. Gut. 2004;53:1190–1197
  27. Schroder O, Schrott M, Blumenstein I, Jahnel J, Dignass AU, Stein J. A study for the evaluation of safety and tolerability of intravenous high-dose iron sucrose in patients with iron deficiency anemia due to gastrointestinal bleeding. Z Gastroenterol. 2004;42:663–667
  28. Gasche C, Dejaco C, Waldhoer T, Tillinger W, Reinisch W, Fueger GF, et al. Intravenous iron and erythropoietin for anemia associated with Crohn disease (A randomized, controlled trial). Ann Intern Med. 1997;126:782–787
  29. Gasche C, Dejaco C, Reinisch W, Tillinger W, Waldhoer T, Fueger GF, et al. Sequential treatment of anemia in ulcerative colitis with intravenous iron and erythropoietin. Digestion. 1999;60:262–267
  30. Bodemar G, Kechagias S, Almer S, Danielson BG. Treatment of anaemia in inflammatory bowel disease with iron sucrose. Scand J Gastroenterol. 2004;39:454–458
  31. Schroder O, Mickisch O, Seidler U, de Weerth A, Dignass AU, Herfarth H, et al. Intravenous iron sucrose versus oral iron supplementation for the treatment of iron deficiency anemia in patients with inflammatory bowel disease—A randomized, controlled, open-label, multicenter study. Am J Gastroenterol. 2005;100:2503–2509
  32. Erichsen K, Ulvik RJ, Nysaeter G, Johansen J, Ostborg J, Berstad A, et al. Oral ferrous fumarate or intravenous iron sucrose for patients with inflammatory bowel disease. Scand J Gastroenterol. 2005;40:1058–1065
  33. Gasche C, Waldhoer T, Feichtenschlager T, Male C, Mayer A, Mittermaier C, et al. Prediction of response to iron sucrose in inflammatory bowel disease-associated anemia. Am J Gastroenterol. 2001;96:2382–2387
  34. Wells CW, Lewis S, Barton JR, Corbett S. Effects of changes in hemoglobin level on quality of life and cognitive function in inflammatory bowel disease patients. Inflamm Bowel Dis. 2006;12:123–130
  35. Crawford J, Cella D, Cleeland CS, Cremieux PY, Demetri GD, Sarokhan BJ, et al. Relationship between changes in hemoglobin level and quality of life during chemotherapy in anemic cancer patients receiving epoetin alfa therapy. Cancer. 2002;95:888–895
  36. Vijverman A, Piront P, Belaiche J, Louis E. Evolution of the prevalence and characteristics of anemia in inflammatory bowel diseases between 1993 nd 2003. Acta Gastroenterol Belg. 2006;69:1–4
  37. Ershler WB, Chen K, Reyes EB, Dubois R. Economic burden of patients with anemia in selected diseases. Value Health. 2005;8:629–638
  38. Ebinger M, Leidl R, Thomas S, Von Tirpitz C, Reinshagen M, Adler G, et al. Cost of outpatient care in patients with inflammatory bowel disease in a German University Hospital. J Gastroenterol Hepatol. 2004;19:192–199
  39. Lakatos L, Pandur T, David G, Balogh Z, Kuronya P, Tollas A, et al. Association of extraintestinal manifestations of inflammatory bowel disease in a province of western Hungary with disease phenotype: Results of a 25-year follow-up study. World J Gastroenterol. 2003;9:2300–2307
  40. Oldenburg B, Koningsberger JC, Berge Henegouwen GP, Van Asbeck BS, Marx JJ. Iron and inflammatory bowel disease. Aliment Pharmacol Ther. 2001;15:429–438
  41. Revel-Vilk S, Tamary H, Broide E, Zoldan M, Dinari G, Zahavi I, et al. Serum transferrin receptor in children and adolescents with inflammatory bowel disease. Eur J Pediatr. 2000;159:585–589
  42. Schreiber S, Howaldt S, Schnoor M, Nikolaus S, Bauditz J, Gasche C, et al. Recombinant erythropoietin for the treatment of anemia in inflammatory bowel disease. N Engl J Med. 1996;334:619–623
  43. Horina JH, Petritsch W, Schmid CR, Reicht G, Wenzl H, Silly H, et al. Treatment of anemia in inflammatory bowel disease with recombinant human erythropoietin: Results in three patients. Gastroenterology. 1993;104:1828–1831
  44. Harries AD, Fitzsimons E, Dew MJ, Heatley RV, Rhodes J. Association between iron deficiency anaemia and mid-arm circumference in Crohn’s disease. Hum Nutr Clin Nutr. 1984;38:47–53
  45. Bambach CP, Hill GL. Long term nutritional effects of extensive resection of the small intestine. Aust N Z J Surg. 1982;52:500–506
  46. Werlin SL, Grand RJ. Severe colitis in children and adolescents: diagnosis (Course, and treatment). Gastroenterology. 1977;73:828–832
  47. Reilly J, Ryan JA, Strole W, Fischer JE. Hyperalimentation in inflammatory bowel disease. Am J Surg. 1976;131:192–200
  48. Reilly J, Ryan JA, Strole W, Fischer JE. Hyperalimentation in inflammatory bowel disease. Am J Surg. 1976;131:192–200
  49. Greenstein AJ, Kark AE, Dreiling DA. Crohn’s disease of the colon (II. Controversial aspects of hemorrhage, anemia and rectal involvement in granulomatous disease involving the colon). Am J Gastroenterol. 1975;63:40–48
  50. Burbige EJ, Huang SH, Bayless TM. Clinical manifestations of Crohn’s disease in children and adolescents. Pediatrics. 1975;55:866–871
  51. Beeken WL. Remediable defects in Crohn disease: A prospective study of 63 patients. Arch Intern Med. 1975;135:686–690
  52. Beeken WL. Absorptive defects in young people with regional enteritis. Pediatrics. 1973;52:69–74
  53. Dyer NH, Child JA, Mollin DL, Dawson AM. Anaemia in Crohn’s disease. Q J Med. 1972;41:419–436
  54. Hoffbrand AV, Stewart JS, Booth CC, Mollin DL. Folate deficiency in Crohn’s disease: Incidence, pathogenesis, and treatment. Br Med J. 1968;597:71–75

PII: S0037-1963(06)00165-X

doi: 10.1053/j.seminhematol.2006.08.010

Seminars in Hematology
Volume 43 , Pages S18-S22 , October 2006