Seminars in Hematology
Volume 43 , Pages S32-S35 , October 2006

Role of Intravenous Iron in Elective and Non-elective Orthopedic Surgery

  • José Antonio García-Erce

      Affiliations

    • Departments of Hematology, University Hospital “Miguel Servet,” Zaragoza, Spain.
    • ,
  • Jorge Cuenca

      Affiliations

    • Department of Orthopedic Surgery and Traumatology, University Hospital “Miguel Servet,” Zaragoza, Spain.
    • ,
  • Manuel Muñoz

      Affiliations

    • GIEMSA, School of Medicine, University of Málaga, Málaga, Spain.
    • Corresponding Author InformationAddress correspondence to Manuel Muñoz, MD, PhD, GIEMSA, Facultad de Medicina, Universidad de Málaga, Campus de Teatinos, s/n, 29071 Málaga, Spain.

References 

  1. Rosencher N, Kerkkamp HE, Macheras G, Munuera LM, Menichella G, Barton DM, et al. Orthopedic Surgery Transfusion Hemoglobin European Overview (OSTHEO) study: Blood management in elective knee and hip arthroplasty in Europe. Transfusion. 2003;43:459–469
  2. Carson JL, Altman DG, Duff A, Noveck H, Weinstein MP, Sonnenberg FA, et al. Risk of bacterial infection associated with allogenic blood transfusion among patients undergoing hip fracture repair. Transfusion. 1999;39:694–700
  3. García-Erce JA, Cuenca J, Solano VM. Factores predictivos de la necesidad de transfuseón en la fractura subcapital de cadera en pacientes mayores de 65 años. Med Clin (Barc). 2003;120:161–166
  4. Cuenca J, García-Erce JA, Martínez AA, Solano VM, Modrego JF. Seguridad y eficacia del hierro intravenoso en la anemia aguda por fractura trocantérea de cadera en el anciano. Med Clin (Barc). 2004;123:281–285
  5. Cuenca J, García-Erce JA, Muñoz M, Izuel M, Martínez AA, Herrera A. Patients with pertrochanteric hip fracture may benefit from preoperative intravenous iron therapy: A pilot study. Transfusion. 2004;44:1447–1452
  6. Cuenca J, García-Erce JA, Martínez AA, Solano VM, Molina J, Muñoz M. Role of parenteral iron in the management of anaemia in the elderly patient undergoing displaced subcapital hip fracture repair (Preliminary data). Arch Orthop Trauma Surg. 2005;125:342–347
  7. García-Erce JA, Cuenca J, Muñoz M, Izuel M, Martinez AA, Herrara A, et al. Perioperative stimulation of erythropoiesis with intravenous iron and erythropoietin reduces transfusion requirements in patients with hip fracture (A prospective observational study). Vox Sang. 2005;89:235–243
  8. Cuenca J, García-Erce JA, Martínez F, Cardona R, Pérez-Serrano L, Muñoz M: Preoperative haematinics and transfusion protocol reduce the need for transfusion after total knee replacement. Int J Surg (in press)
  9. Bisbe E, Rodríguez C, Ruiz A, Sáez M, Castillo J, Santiveri X. Uso preoperatorio de hierro endovenoso (Una nueva terapéutica en medicina transfusional). Rev Esp Anestesiol Reanim. 2005;52:536–540
  10. Messmer K. Consensus statement: Using epoetin alfa to decrease the risk of allogeneic blood transfusion in the surgical setting (Roundtable of Experts in Surgery Blood Management). Semin Hematol. 1996;33(suppl 2):78–80
  11. Cuenca J, García-Erce JA, Martínez F, Pérez-Serrano L, Herrera A, Muñoz M. Perioperative intravenous iron, with or without erythropoietin, plus restrictive transfusion protocol reduce the need for allogeneic blood after knee replacement surgery. Transfusion. 2006;46:1112–1119
  12. Weber EW, Slappendel R, Hémon Y, Mähler S, Dalen T, Rowet E, et al. Effects of epoetin alfa on blood transfusions and postoperative recovery in orthopaedic surgery: The European Epoetin Alfa Surgery Trial (EEST). Eur J Anaesthesiol. 2005;22:249–257
  13. Mundy GM, Birtwistle SJ, Power RA. The effect of iron supplementation on the level of haemoglobin after lower limb arthroplasty. J Bone Joint Surg Br. 2005;87:213–217
  14. Bernière J, Dehullu JP, Gall O, Murat I. Intravenous iron in the treatment of postoperative anemia in surgery of the spine in infants and adolescents. Rev Chir Orthop. 1998;84:319–322
  15. Muñoz M, Naveira E, Seara J, Palmer JH, Cuenca J, García-Erce JA. Role of parenteral iron on transfusion requirements after total hip replacement (A pilot study). Transfus Med. 2006;16:137–142
  16. García-Erce JA, Cuenca J, Martínez F, Cardona R, Pérez-Serrano L, Muñoz M: Perioperative intravenous iron preserves iron stores and may hasten the recovery from postoperative anaemia after knee replacement surgery. Transfus Med (in press)
  17. Wallis JP, Wells AW, Whitehead S, Brewster N. Recovery from post-operative anaemia. Transfus Med. 2005;15:413–418

PII: S0037-1963(06)00162-4

doi: 10.1053/j.seminhematol.2006.08.006

Seminars in Hematology
Volume 43 , Pages S32-S35 , October 2006

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