Seminars in Hematology
Volume 43 , Pages S1-S2 , July 2006

Review of Therapies for Immune Thrombocytopenic Purpura

  • James Bussel, MD (Guest Editor)

      Affiliations

    • Weill Medical College of Cornell University, New York, NY
    • ,
  • Michael Tarantino, MD (Guest Editor)

      Affiliations

    • University of Illinois College of Medicine at Peoria, Peoria, IL

References 

  1. George JN , Woolf SH , Raskob GE , Wasser JS , Aledort LM , Ballem PJ , et al.   Idiopathic thrombocytopenic purpura (a practice guideline developed by explicit methods for the American Society of Hematology) . Blood . 1996;88:3–40
  2. Cines DB , Bussel JB . How I treat idiopathic thrombocytopenic purpura (ITP) . Blood . 2005;106:2244–2251
  3. Tarantino MD , Young G , Bertolone SJ , Kalinyak KA , Shafer FE , Kulkarni R , et al.  Acute ITP in Children Study Group   Single dose of anti-D immune globulin at 75 μg/kg is as effective as intravenous immune globulin at rapidly raising the platelet count in newly diagnosed immune thrombocytopenic purpura (ITP) in children . J Pediatr . 2006;148:489–494
  4. Bussel JB , Graziano JN , Kimberly RP , Pahwa S , Aledort LM . Intravenous anti-D treatment of immune thrombocytopenic purpura (Analysis of efficacy, toxicity, and mechanism of effect) . Blood . 1991;77:1884–1893
  5. Newman GC , Novoa MV , Fodero EM , Lesser ML , Woloski BMR , Bussel JB . A dose of 75 μg/kg/d of IV anti-D increases the platelet count more rapidly and for a longer period of time than does 50 μg/kg/d in adults with immune thrombocytopenic purpura (ITP) . Br J Haematol . 2001;112:1076–1078
  6. Gaines AR . Acute onset hemoglobinemia and/or hemoglobinuria and sequelae following Rh(o)(D) immune globulin intravenous administration in immune thrombocytopenic purpura patients . Blood . 2000;95:2523–2529
  7. Gaines AR . Disseminated intravascular coagulation associated with acute hemoglobinemia or hemoglobinuria following Rh(0)(D) immune globulin intravenous administration for immune thrombocytopenic purpura . Blood . 2005;106:1532–1537
  8. Schwartz J , Eldor A , Gillis S , Guinta A , Leber M , Bussel JB . Long term follow-up after splenectomy performed for immune thrombocytopenic purpura (ITP) . Am J Hematol . 2003;72:94–98
  9. Kojouri K , Vesely SK , Terrell DR , George JN . Splenectomy for adult patients with idiopathic thrombocytopenic purpura (A systematic review to assess long-term platelet count responses, prediction of response, and surgical complications) . Blood . 2004;104:2623–2634
  10. Fabris F , Tassan T , Ramon R , Carraro G , Randi ML , Luzzatto G , et al.   Age as the major predictor of long-term response to splenectomy in immune thrombocytopenic purpura . Br J Haematol . 2001;112:637–640
  11. Law C , Marcaccio M , Tam P , Heddle N , Kelton JG . High-dose intravenous immune globulin and the response to splenectomy in patients with idiopathic thrombocytopenic purpura . N Engl J Med . 1997;336:1494–1498
  12. Holt D , Brown J , Terrill K , Goldsby R , Meyers RL , Heximer J , et al.   Response to intravenous immunoglobulin predicts splenectomy response in children with immune thrombocytopenic purpura . Pediatrics . 2003;111:87–90
  13. Najean Y , Rain JD , Billotey C . The site of destruction of autologous 111In-labelled platelets and the efficiency of splenectomy in children and adults with idiopathic thrombocytopenic purpura (a study of 578 patients with 268 splenectomies) . Br J Haematol . 1997;97:547–550
  14. Cooper N, Woloski BM, Fodero EM, Novoa M, Leber M, Beer JH, et al. Does treatment with intermittent infusions of intravenous anti-D allow a proportion of adults with recently diagnosed immune thrombocytopenic purpura to avoid splenectomy? . Blood . 2002;99:1922–1927
  15. George JN , Raskob GE , Vesely SK , Moore D , Lyons RM , Cobos E , et al.   Initial management of immune thrombocytopenic purpura in adults (A randomized controlled trial comparing intermittent anti-D with routine care) . Am J Hematol . 2003;74:161–169
  16. Cooper N , Stasi R , Cunningham-Rundles S , Feuerstein MA , Leonard JP , Amadori S , et al.   The efficacy and safety of B-cell depletion with anti-CD20 monoclonal antibody in adults with chronic immune thrombocytopenic purpura . Br J Haematol . 2004;125:232–239
  17. Kuter D , Bussel JB , Aledort LM , George J , Lyons RM , Conklin GT , et al.   A phase 2 placebo controlled study evaluating the platelet response and safety of weekly dosing with a novel thrombopoietic protein (AMG531) in thrombocytopenic adult patients (pts) with immune thrombocytopenic purpura (ITP) . [abstract] Blood . 2004;104(suppl):148a
  18. Newland A , Caulier MT , Schipperus MR , Kappers-Klunne M , Varet BR , Watkins K , et al.   An open-label, unit dose-finding study evaluating the safety and platelet response of a novel thrombopoietic protein (AMG531) in thrombocytopenic adult patients (pts) with immune thrombocytopenic purpura (ITP) . [abstract] Blood . 2004;104(suppl):567a
  19. Bussel JB , Kuter DJ , George JN , Aledort LM , Lichtin AE , Lyons RM , et al.   Long-term dosing of AMG 531 is effective and well tolerated in thrombocytopenic patients with immune thrombocytopenic purpura . 2005; Presented at the 47th ASH Annual Meeting and Exposition, Atlanta, GA, December 10-13, (abstr 220)
  20. Cooper N , Heddle NM , Haas M , Reid ME , Lesser ML , Fleit HB , et al.   Intravenous (IV) anti-D and IV immunoglobulin achieve acute platelet increases by different mechanisms (Modulation of cytokine and platelet responses to IV anti-D by FcγRIIa and FcγRIIIa polymorphisms) . Br J Haematol . 2004;124:511–518

PII: S0037-1963(06)00092-8

doi: 10.1053/j.seminhematol.2006.04.010

Seminars in Hematology
Volume 43 , Pages S1-S2 , July 2006

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