Seminars in Hematology
Volume 43 , Pages S18-S21 , April 2006

Surgery in Patients With Hemophilia and Inhibitors: A Review of the Norwegian Experience With FEIBA

  • Geir E. Tjønnfjord

      Affiliations

    • Corresponding Author InformationAddress correspondence to Geir E. Tjønnfjord, MD, PhD, Medical Department, Division of Hematology, Rikshospitalet–Radiumhospitalet University Hospital, N-0027 Oslo, Norway.

References 

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  2. Sjamsoedin LJM , Heijnen L , Mauser-Bunschoten EP , van Geijlswijk JL , van Houwelingen H , van Asten P , et al.   The effect of activated prothrombin-complex concentrate (FEIBA) on joint and muscle bleeding in patients with hemophilia A and antibodies to factor VIII. A double-blind clinical trial . N Engl J Med . 1981;305:717–721
  3. Bech RBM , Nielsen L , Falch JF , Glazer S , Hedner U . Evaluation of efficacy of recombinant factor VIIa in 149 patients treated for critical bleeds . Blood . 1994;84:68a; (abstr 262)
  4. Rodriguez-Merchan EC , Rocino A . Literature review of surgery management in inhibitor patients . Haemophilia . 2004;10(suppl 2):22–29
  5. Hilgartner MW , Knatterud GL . The use of factor eight inhibitor by-passing activity (FEIBA immuno) product for treatment of bleeding episodes in hemophiliacs with inhibitors . Blood . 1983;61:36–40
  6. Negrier C , Goudemand J , Sultan Y , Bertrand M , Rothschild C , Lauroua P  French FEIBA Study Group . Multicenter retrospective study on the utilization of FEIBA in France in patients with factor VIII and factor IX inhibitors . Thromb Haemost . 1997;77:1113–1119 Factor Eight Bypassing Activity
  7. Faradji A , Bonnomet F , Lecocq J , Grunebaum L , Desprez D , Kern O , et al.   Knee joint arthroplasty in a patient with haemophilia A and high inhibitor titre using recombinant factor VIIa (NovoSeven) (A new case report and review of the literature) . Haemophilia . 2001;7:321–326
  8. Hedner U , Glazer S , Pingel K , Alberts KA , Blombäck M , Schulman S , et al.   Successful use of recombinant factor VIIa in patient with severe haemophilia A during synovectomy . Lancet . 1988;2:1193
  9. Heisel MA , Gomperts ED , McComb JG , Hilgartner M . Use of activated prothrombin complex concentrate over multiple surgical episodes in a hemophilic child with an inhibitor . J Pediatr . 1983;102:951–954
  10. Hutchinson RJ , Penner JA , Hensinger RN . Anti-inhibitor coagulant complex (Autoplex) in hemophilia inhibitor patients undergoing synovectomy . Pediatrics . 1983;71:631–633
  11. Hvid I , Rodriguez-Merchan EC . Orthopaedic surgery in haemophilic patients with inhibitors (An overview) . Haemophilia . 2002;8:288–291
  12. Ingerslev J . Efficacy and safety of recombinant factor VIIa in the prophylaxis of bleeding in various surgical procedures in hemophilic patients with factor VIII and factor IX inhibitors . Semin Thromb Hemost . 2000;26:425–432
  13. O’Marcaigh AS , Schmalz BJ , Shaughnessy WJ , Gilchrist GS . Successful hemostasis during a major orthopedic operation by using recombinant activated factor VII in a patient with severe hemophilia A and a potent inhibitor . Mayo Clin Proc . 1994;69:641–644
  14. Rodriguez-Merchan EC , Wiedel JD , Wallny T , Hvid I , Berntorp E , Rivard G-E , et al.   Elective orthopaedic surgery for inhibitor patients . Haemophilia . 2003;9:625–631
  15. Schulman S , Lindstedt M , Alberts KA , Agren PH . Recombinant factor VIIa in multiple surgery . Thromb Haemost . 1994;71:154
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  19. Tjønnfjord GE , Brinch L , Gedde-Dahl T , Brosstad FR . Activated prothrombin complex concentrate (FEIBA) treatment during surgery in patients with inhibitors to FVIII/IX . Haemophilia . 2004;10:174–178

 This manuscript is based in part on the proceedings from an educational symposium held at the World Federation of Hemophilia World Congress 2004 in Bangkok, Thailand. Both the symposium and this manuscript were supported by Baxter Healthcare Corporation.

PII: S0037-1963(06)00049-7

doi: 10.1053/j.seminhematol.2006.03.003

Seminars in Hematology
Volume 43 , Pages S18-S21 , April 2006

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