Seminars in Hematology
Volume 43, Issue 2 , Pages 82-88 , April 2006

Etiology of Acute Myeloid Leukemia in the Elderly

  • David T. Bowen

      Affiliations

    • Corresponding Author InformationAddress correspondence to David T. Bowen, MD, Consultant Haematologist, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK

References 

  1. Preiss BS , Kerndrup GB , Schmidt KG , Sorensen AG , Clausen NA , Gadeberg OV , et al.   Cytogenetic findings in adult de novo acute myeloid leukaemia. A population-based study of 303/337 patients . Br J Haematol . 2003;123:219–234
  2. Moorman AV , Roman E , Willett EV , Dovey GJ , Cartwright RA , Morgan GJ . Karyotype and age in acute myeloid leukemia. Are they linked? . Cancer Genet Cytogenet . 2001;126:155–161
  3. Schoch C , Kern W , Krawitz P , Dugas M , Schnittger S , Haferlach T , et al.   Dependence of age-specific incidence of acute myeloid leukemia on karyotype . Blood . 2001;98:3500; letter
  4. Vickers M , Jackson G , Taylor P . The incidence of acute promyelocytic leukemia appears constant over most of a human lifespan, implying only one rate limiting mutation . Leukemia . 2000;14:722–726
  5. Cartwright RA , Gurney KA , Moorman AV . Sex ratios and the risks of haematological malignancies . Br J Haematol . 2002;118:1071–1077
  6. Sanderson RN , Johnson PRE , Moorman AV , Roman E , Willett E , Proctor SJ , et al.   Population-based demographic study of karyotypes in 1709 patients with adult acute myeloid leukemia . Leukemia . 2006; Jan 19 [Epub ahead of print]
  7. Pedersen-Bjergaard J , Andersen MK , Christiansen DH , Nerlov C . Genetic pathways in therapy-related myelodysplasia and acute myeloid leukemia . Blood . 2002;99:1909–1912
  8. Suzuki T , Kiyoi H , Ozeki K , Tomita A , Yamaji S , Suzuki R , et al.   Clinical characteristics and prognostic implications of NPM1 mutations in acute myeloid leukemia . Blood . 2005;101:2770–2794
  9. Schoch C , Kern W , Kohlmann A , Hiddemann W , Schnittger S , Haferlach T . Acute myeloid leukemia with a complex aberrant karyotype is a distinct biological entity characterized by genomic imbalances and a specific gene expression profile . Genes Chromosomes Cancer . 2005;43:227–238
  10. Valk PJ , Verhaak RG , Beijen MA , Erpelinck CA , Barjesteh van Waalwijk van Doorn-Khosrovani S , Boer JM , et al.   Prognostically useful gene-expression profiles in acute myeloid leukemia . N Engl J Med . 2004;350:1617–1628
  11. Kottaridis PD , Gale RE , Langabeer SE , Frew ME , Bowen DT , Linch DC . Studies of FLT3 mutations in paired presentation and relapse samples from patients with acute myeloid leukemia (Implications for the role of FLT3 mutations in leukemogenesis, minimal residual disease detection, and possible therapy with FLT3 inhibitors) . Blood . 2002;100:2393–2398
  12. Richardson S , Zittoun R , Bastuji Garin S , Lasserre V , Guihenneuc C , Cadiou M , et al.   Occupational risk factors for acute leukaemia (A case-control study) . Int J Epidemiol . 1992;21:1063–1073
  13. Ciccone G , Mirabelli D , Levis A , Gavarotti P , Rege-Cambrin G , Davico L , et al.   Myeloid leukemias and myelodysplastic syndromes (Chemical exposure, histologic subtype and cytogenetics in a case-control study) . Cancer Genet Cytogenet . 1993;68:135–139
  14. Lazarov D , Waldron HA , Pejin D . Acute myeloid leukaemia and exposure to organic solvents—A case-control study . Eur J Epidemiol . 2000;16:295–301
  15. Speer SA , Semenza JC , Kurosaki T , Anton-Culver H . Risk factors for acute myeloid leukemia and multiple myeloma (A combination of GIS and case-control studies) . J Environ Health . 2002;64:9–16
  16. Nisse C , Haguenoer JM , Grandbastien B , Preudhomme C , Fontaine B , Brillet JM , et al.   Occupational and environmental risk factors of the myelodysplastic syndromes in the North of France . Br J Haematol . 2001;112:927–935
  17. Rigolin GM , Cuneo A , Roberti MG , Bardi A , Bigoni R , Piva N , et al.   Exposure to myelotoxic agents and myelodysplasia (Case-control study and correlation with clinicobiological findings) . Br J Haematol . 1998;103:189–197
  18. Bjork J , Albin M , Mauritzson N , Stromberg U , Johansson B , Hagmar L . Smoking and myelodysplastic syndromes . Epidemiology . 2000;11:285–291
  19. Aksoy M , Erdem S . Followup study on the mortality and the development of leukemia in 44 pancytopenic patients with chronic exposure to benzene . Blood . 1978;52:285–292
  20. Paustenbach DJ , Bass RD , Price P . Benzene toxicity and risk assessment, 1972-1992 (Implications for future regulation) . Environ Health Perspect . 1993;101(suppl 6):177–200
  21. Smith MT . Mechanistic studies of benzene toxicity—Implications for risk assessment . Adv Exp Med Biol . 1996;387:259–266
  22. Zeise L , McDonald TA . California perspective on the assessment of benzene toxicological risks . J Toxicol Environ Health A . 2000;61:479–483
  23. Hotz P , Lauwerys RR . Hematopoietic and lymphatic malignancies in vehicle mechanics . Crit Rev Toxicol . 1997;27:443–494
  24. Boffetta P . Risk of acute myeloid leukemia after exposure to diesel exhaust (A review of the epidemiologic evidence) . J Occup Environ Med . 2004;46:1076–1083
  25. Smith MT , Zhang LP , Wang YX , Hayes RB , Li GL , Wiemels J , et al.   Increased translocations and aneusomy in chromosomes 8 and 21 among workers exposed to benzene . Cancer Res . 1998;58:2176–2181
  26. Zhang L , Wang Y , Shang N , Smith MT . Benzene metabolites induce the loss and long arm deletion of chromosomes 5 and 7 in human lymphocytes . Leuk Res . 1998;22:105–113
  27. Smith MT , Zhang L , Jeng M , Wang Y , Guo W , Duramad P , et al.   Hydroquinone, a benzene metabolite, increases the level of aneusomy of chromosomes 7 and 8 in human CD34-positive blood progenitor cells . Carcinogenesis . 2000;21:1485–1490
  28. Shimizu Y , Schull WJ , Kato H  Radiation Effects Research Foundation . Cancer risk among atomic bomb survivors. The RERF Life Span Study . JAMA . 1990;264:601–604
  29. Pearce N , Prior I , Methven D , Culling C , Marshall S , Auld J , et al.   Follow up of New Zealand participants in British atmospheric nuclear weapons tests in the Pacific . BMJ . 1990;300:1161–1166
  30. Darby SC , Kendall GM , Fell TP , Doll R , Goodill AA , Conquest AJ , et al.   Further follow up of mortality and incidence of cancer in men from the United Kingdom who participated in the United Kingdom’s atmospheric nuclear weapon tests and experimental programmes . BMJ . 1993;307:1530–1535
  31. Doody MM , Mandel JS , Lubin JH , Boice JD . Mortality among United States radiologic technologists, 1926-90 . Cancer Causes Control . 1998;9:67–75
  32. Cardis E , Gilbert ES , Carpenter L , Howe G , Kato I , Armstrong BK , et al.   Effects of low doses and low dose rates of external ionizing radiation (Cancer mortality among nuclear industry workers in three countries) . Radiat Res . 1995;142:117–132
  33. Weiss HA , Darby SC , Fearn T , Doll R . Leukemia mortality after x-ray treatment for ankylosing spondylitis . Radiat Res . 1995;142:1–11
  34. Inskip PD , Monson RR , Wagoner JK , Stovall M , Davis FG , Kleinerman RA , et al.   Leukemia following radiotherapy for uterine bleeding . Radiat Res . 1990;122:107–119
  35. Urowitz MB , Rider WD . Myeloproliferative disorders in patients with rheumatoid arthritis treated with total body irradiation . Am J Med . 1985;78:60–64
  36. Inskip PD , Kleinerman RA , Stovall M , Cookfair DL , Hadjimichael O , Moloney WC , et al.   Leukemia, lymphoma, and multiple myeloma after pelvic radiotherapy for benign disease . Radiat Res . 1993;135:108–124
  37. Griem ML , Kleinerman RA , Boice JD , Stovall M , Shefner D , Lubin JH . Cancer following radiotherapy for peptic ulcer . J Natl Cancer Inst . 1994;86:842–849
  38. Travis LB , Curtis RE , Storm H , Hall P , Holowaty E , Vanleeuwen FE , et al.   Risk of second malignant neoplasms among long-term survivors of testicular cancer . J Natl Cancer Inst . 1997;89:1429–1439
  39. Curtis RE , Boice JD , Stovall M , Bernstein L , Greenberg RS , Flannery JT , et al.   Risk of leukemia after chemotherapy and radiation treatment for breast cancer . N Engl J Med . 1992;326:1745–1751
  40. Curtis RE , Boice JD , Stovall M , Bernstein L , Greenberg RS , Flannery JT , et al.   Risk of leukemia after chemotherapy and radiation treatment for breast cancer . N Engl J Med . 1992;326:1745–1751
  41. Armitage JO , Carbone PP , Connors JM , Levine A , Bennett JM , Kroll S . Treatment-related myelodysplasia and acute leukemia in non-Hodgkin’s lymphoma patients . J Clin Oncol . 2003;21:897–906
  42. Gundestrup M , Storm HH . Radiation-induced acute myeloid leukaemia and other cancers in commercial jet cockpit crew (A population-based cohort study) . Lancet . 1999;354:2029–2031
  43. Ballard T , Lagorio S , De Angelis G , Verdecchia A . Cancer incidence and mortality among flight personnel (A meta-analysis) . Aviat Space Environ Med . 2000;71:216–224
  44. Pukkala E , Aspholm R , Auvinen A , Eliasch H , Gundestrup M , Haldorsen T , et al.   Cancer incidence among 10,211 airline pilots (A Nordic study) . Aviat Space Environ Med . 2003;74:699–706
  45. Reynolds TY , Rockwell S , Glazer PM . Genetic instability induced by the tumor microenvironment . Cancer Res . 1996;56:5754–5757
  46. Lorimore SA , Coates PJ , Scobie GE , Milne G , Wright EG . Inflammatory-type responses after exposure to ionizing radiation in vivo (A mechanism for radiation-induced bystander effects?) . Oncogene . 2001;20:7085–7095
  47. Chen R , Seaton A . A meta-analysis of painting exposure and cancer mortality . Cancer Detect Prev . 1998;22:533–539
  48. Nilsson RI , Nordlinder R , Horte LG , Jarvholm B . Leukaemia, lymphoma, and multiple myeloma in seamen on tankers . Occup Environ Med . 1998;55:517–521
  49. Sathiakumar N , Delzell E , Hovinga M , Macaluso M , Julian JA , Larson R , et al.   Mortality from cancer and other causes of death among synthetic rubber workers . Occup Environ Med . 1998;55:230–235
  50. Metayer C , Johnson ES , Rice JC . Nested case-control study of tumors of the hemopoietic and lymphatic systems among workers in the meat industry . Am J Epidemiol . 1998;147:727–738
  51. Hayes RB , Blair A , Stewart PA , Herrick RF , Mahar H . Mortality of U.S. embalmers and funeral directors . Am J Ind Med . 1990;18:641–652
  52. McDonald TA , Holland NT , Skibola C , Duramad P , Smith MT . Hypothesis (Phenol and hydroquinone derived mainly from diet and gastrointestinal flora are causal factors in leukemia) . Leukemia . 2001;15:10–20
  53. Ross JA , Kasum CM , Davies SM , Jacobs DR , Folsom AR , Potter JD . Diet and risk of leukemia in the Iowa Women’s Health Study . Cancer Epidemiol Biomarkers Prev . 2002;11:777–781
  54. Hursting SD , Margolin BH , Switzer BR . Diet and human leukemia—An analysis of international data . Prevent Med . 1993;22:409–422
  55. Kane EV , Roman E , Cartwright R , Parker J , Morgan G . Tobacco and the risk of acute leukaemia in adults . Br J Cancer . 1999;81:1228–1233
  56. Bjork J , Albin M , Mauritzson N , Stromberg U , Johansson B , Hagmar L . Smoking and acute myeloid leukemia (Associations with morphology and karyotypic patterns and evaluation of dose-response relations) . Leuk Res . 2001;25:865–872
  57. Korte JE , Hertz-Picciotto I , Schulz MR , Ball LM , Duell EJ . The contribution of benzene to smoking-induced leukemia . Environ Health Perspect . 2000;108:333–339
  58. Brown LM , Gibson R , Burmeister LF , Schuman LM , Everett GD , Blair A . Alcohol consumption and risk of leukemia, non-Hodgkin’s lymphoma, and multiple myeloma . Leuk Res . 1992;16:979–984
  59. Mele A , Szklo M , Visani G , Stazi MA , Castelli G , Pasquini P , et al.  Italian Leukemia Study Group   Hair dye use and other risk factors for leukemia and pre-leukemia (A case-control study) . Am J Epidemiol . 1994;139:609–619
  60. Correa A , Mohan A , Jackson L , Perry H , Helzlsouer K . Use of hair dyes, hematopoietic neoplasms, and lymphomas: A literature review. I. Leukemias and myelodysplastic syndromes . Cancer Invest . 2000;18:366–380
  61. Caspi O , Polliack A , Klar R , Ben Yehuda D . The association of inflammatory bowel disease and leukemia—Coincidence or not? . Leuk Lymphoma . 1995;17:255–262
  62. Askling J , Brandt L , Lapidus A , Karlen P , Bjorkholm M , Lofberg R , et al.   Risk of haematopoietic cancer in patients with inflammatory bowel disease . Gut . 2005;54:617–622
  63. Gentile G , Mele A , Monarco B , Vitale A , Pulsoni A , Visani G , et al.  The Italian Leukemia Study Group   Hepatitis B and C viruses, human T-cell lymphotropic virus types I and II, and leukemias (A case-control study) . Cancer Epidemiol Biomarkers Prev . 1996;5:227–230
  64. Cooper GS , Kamel F , Sandler DP , Davey FR , Bloomfield CD . Risk of adult acute leukemia in relation to prior immune-related conditions . Cancer Epidemiol Biomarkers Prev . 1996;5:867–872
  65. Parry TE . The non-random distribution of point mutations in leukaemia and myelodysplasia—A possible pointer to their aetiology . Leuk Res . 1997;21:559–574
  66. Wood RD , Mitchell M , Sgouros J , Lindahl T . Human DNA repair genes . Science . 2001;291:1284–1289
  67. Kutler DI , Singh B , Satagopan J , Batish SD , Berwick M , Giampietro PF , et al.   A 20-year perspective on the International Fanconi Anemia Registry (IFAR) . Blood . 2003;101:1249–1256
  68. Poppe B , Van Limbergen H , Van Roy N , Vandecruys E , De Paepe A , Benoit Y , et al.   Chromosomal aberrations in Bloom syndrome patients with myeloid malignancies . Cancer Genet Cytogenet . 2001;128:39–42
  69. Song WJ , Sullivan MG , Legare RD , Hutchings S , Tan X , Kufrin D , et al.   Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia . Nat Genet . 1999;23:166–175
  70. Gowans ID , Lorimore SA , McIlrath JM , Wright EG . Genotype-dependent induction of transmissible chromosomal instability by gamma-radiation and the benzene metabolite hydroquinone . Cancer Res . 2005;65:3527–3530
  71. Boulton E , Cole C , Knight A , Cleary H , Snowden R , Plumb M . Low-penetrance genetic susceptibility and resistance loci implicated in the relative risk for radiation-induced acute myeloid leukemia in mice . Blood . 2003;101:2349–2354
  72. Seedhouse C , Faulkner R , Ashraf N , Das-Gupta E , Russell N . Polymorphisms in genes involved in homologous recombination repair interact to increase the risk of developing acute myeloid leukemia . Clin Cancer Res . 2004;10:2675–2680
  73. Larson RA , Wang Y , Banerjee M , Wiemels J , Hartford C , Le Beau MM , et al.   Prevalence of the inactivating 609C→T polymorphism in the NAD(P)H:quinone oxidoreductase (NQO1) gene in patients with primary and therapy-related myeloid leukemia . Blood . 1999;94:803–807
  74. Allan JM , Wild CP , Rollinson S , Willett EV , Moorman AV , Dovey GJ , et al.   Polymorphism in glutathione S-transferase P1 is associated with susceptibility to chemotherapy-induced leukemia . Proc Natl Acad Sci U S A . 2001;98:11592–11597
  75. Worrillow LJ , Travis LB , Smith AG , Rollinson S , Smith AJ , Wild CP , et al.   An intron splice acceptor polymorphism in hMSH2 and risk of leukemia after treatment with chemotherapeutic alkylating agents . Clin Cancer Res . 2003;9:3012–3020
  76. Sibley K , Rollinson S , Allan JM , Smith AG , Law GR , Roddam PL , et al.   Functional FAS promoter polymorphisms are associated with increased risk of acute myeloid leukemia . Cancer Res . 2003;63:4327–4330
  77. Bowen DT , Frew ME , Rollinson S , Roddam PL , Dring A , Smith MT , et al.   Cytochrome P450 1A1 *2B (Val) allele is over-represented in a sub-group of acute myeloid leukemia patients with poor-risk karyotype associated with NRAS mutation, but not associated with FLT3 internal tandem duplication . Blood . 2002; 2002–01
  78. Smith MT , Wang Y , Kane E , Rollinson S , Wiemels JL , Roman E , et al.   Low NAD(P)H:quinone oxidoreductase 1 activity is associated with increased risk of acute leukemia in adults . Blood . 2001;97:1422–1426
  79. Bowen DT , Frew ME , Rollinson S , Roddam PL , Dring A , Smith MT , et al.   CYP1A1*2B (Val) allele is overrepresented in a subgroup of acute myeloid leukemia patients with poor-risk karyotype associated with NRAS mutation, but not associated with FLT3 internal tandem duplication . Blood . 2003;101:2770–2774
  80. Crane MM , Strom SS , Halabi S , Berman EL , Fueger JJ , Spitz MR , et al.   Correlation between selected environmental exposures and karyotype in acute myelocytic leukemia . Cancer Epidemiol Biomarkers Prev . 1996;5:639–644
  81. Mauritzson N , Albin M , Rylander L , Billstrom R , Ahlgren T , Mikoczy Z , et al.   Pooled analysis of clinical and cytogenetic features in treatment-related and de novo adult acute myeloid leukemia and myelodysplastic syndromes based on a consecutive series of 761 patients analyzed 1976-1993 and on 5098 unselected cases reported in the literature 1974-2001 . Leukemia . 2002;16:2366–2378
  82. Qian Z , Fernald AA , Godley LA , Larson RA , Le Beau MM . Expression profiling of CD34+ hematopoietic stem/progenitor cells reveals distinct subtypes of therapy-related acute myeloid leukemia . Proc Natl Acad Sci U S A . 2002;99:14925–14930

PII: S0037-1963(06)00022-9

doi: 10.1053/j.seminhematol.2006.01.005

Seminars in Hematology
Volume 43, Issue 2 , Pages 82-88 , April 2006