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Seminars in Hematology
Volume 43, Issue 2
, Pages 107-117
, April 2006
Allogeneic Transplantation for the Elderly Patient With Acute Myelogenous Leukemia or Myelodysplastic Syndrome
References
- . Biological basis of determinants of health . Am J Public Health . 2005;95:389–392
-
SEER: Surveillance, Epidemiology and End Results (SEER). SEER CANCER GOV (accessed on August, 2005)
-
.
Acute myeloid leukemia in the older patient
.
Crit Rev Oncol Hematol
. 2003;48S:17–26
- . Genetics of myeloid leukemias . Annu Rev Genomics Hum Genet . 2002;3:179–198
- . Cell intrinsic alterations underlie hematopoietic stem cell aging . Proc Natl Acad Sci U S A . 2005;102:9194–9199
-
.
Acute myeloid leukemia
.
Hematology (Am Soc Hematol Educ Program)
. 2001;62–86
- Implications of potential cure in acute myelogenous leukemia (Development of subsequent cancer and return to work) . Blood . 1997;90:4719–4724
- . Treatment of newly diagnosed acute myelogenous leukemia in-patients age 80 years and above . Br J Haematol . 1996;93:89–95
- . Nonablative stem cell transplantation for older patients with acute leukemias and myelodysplastic syndromes . Semin Hematol . 2002;39:57–62
- Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients . Blood . 1995;86:2041–2050
- Nonmyeloablative preparative regimens for allogeneic hematopoietic transplantation. Biology and current indications . Oncology (Williston Park) . 2003;17:94–100
- Nonablative allogeneic stem-cell transplantation for advanced/recurrent mantle-cell lymphoma . J Clin Oncol . 2003;21:4407–4412
- . The transplantation of hematopoietic stem cells after non-myeloablative conditioning (A cellular therapeutic approach to hematologic and genetic diseases) . Immunol Res . 2003;28:13–24
- . Unrelated donor transplantation over the age of 55. Are we merely getting (b)older? . Leukemia . 2005;19:31–33
- Acute and chronic graft-versus-host disease after ablative and nonmyeloablative conditioning for allogeneic hematopoietic transplantation . Biol Blood Marrow Transplant . 2004;10:178–185
- . Lessened severe graft-versus-host after “minitransplantations” . Blood . 2005;105:2614
- Comparing morbidity and mortality of HLA-matched unrelated donor hematopoietic cell transplantation after nonmyeloablative and myeloablative conditioning (Influence of pretransplantation comorbidities) . Blood . 2004;104:961–968
- Effect of age and previous autologous transplantation on nonrelapse mortality and survival in patients treated with reduced-intensity conditioning and allografting for advance hematologic malignancies . J Clin Oncol . 2005;23:6690–6698
- Graft-versus-tumor effects after allogeneic hematopoietic cell transplantation with nonmyeloablative conditioning . J Clin Oncol . 2005;23:1993–2003
- . The aging innate immune system . Curr Opin Immunol . 2005;17:1–6
- Prevention of graft versus host disease by inactivation of host antigen-presenting cells . Science . 1999;285:412–415
- Enhanced allostimulatory activity of host antigen-presenting cells in old mice intensifies acute graft-versus-host disease . J Clin Invest . 2002;109:1249–1256
- . Signal transduction in the aging immune system . Curr Opin Immunol . 2005;17:1–6
- . T cell development and receptor diversity during aging . Curr Opin Immunol . 2005;17:1–8
- Donor characteristics as risk factors in recipients after transplantation of bone marrow from unrelated donors (The effect of donor age) . Blood . 2001;98:2043–2051
- . Comorbidity indices in hematopoietic stem cell transplantation (A new report card) . Bone Marrow Transplant . 2005;36:475–479
-
Hematopoietic cell transplantation-specific comorbidity index
(A new tool for risk assessment before allogeneic HCT)
.
Blood
. 2005;
- . A new method of classifying prognostic comorbidity in longitudinal studies (Development and validation) . J Chronic Dis . 1987;40:373–383
- Morbidity and mortality with nonmyeloablative compared with myeloablative conditioning before hematopoietic cell transplantation from HLA-matched related donors . Blood . 2004;104:1550–1558
- Nonablative versus reduced-intensity conditioning regimens in the treatment of acute myeloid leukemia and high-risk myelodysplastic syndrome (Dose is relevant for long-term disease control after allogeneic hematopoietic stem cell transplantation) . Blood . 2004;104:865–872
- . Long-term follow-up of a randomized trial of two irradiation regimens for patients receiving allogeneic marrow transplants during first remission of acute myeloid leukemia . Blood . 1998;92:1455–1456
- Non-myeloablative allografting from human leucocyte antigen-identical sibling donors for treatment of acute myeloid leukaemia in first complete remission . Br J Haematol . 2003;120:281–288
- Engraftment kinetics after nonmyeloablative allogeneic peripheral blood stem cell transplantation (Full donor T-cell chimerism precedes alloimmune responses) . Blood . 1999;94:3234–3241
- Nonmyeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and nonmalignant hematologic diseases . Blood . 1998;91:756–763
- Engraftment of allogeneic hematopoietic progenitor cells with purine analog-containing chemotherapy (harnessing graft-versus-leukemia without myeloablative therapy) . Blood . 1997;89:4531–4536
-
Comparative outcome of reduced intensity and myeloablative conditioning regimen in HLA identical sibling allogeneic hematopoietic stem cell transplantation for patients older than 50 years of age with acute myeloblastic leukaemia
(A retrospective survey from the acute leukemia party (ALWP) of the European group for Blood and Marrow Transplantation (EBMT))
.
Leukemia
. 2005;1–9
[Epub ahead of print:,]
- Comparative outcome of nonmyeloablative and myeloablative allogeneic hematopoietic stem cell transplantation for patients older than 50 years of age . Blood . 2005;105:1810–1814
- Ablative allogeneic hematopoietic cell transplantation in adults 60 years of age and older . J Clin Oncol . 2005;23:3439–3446
- Once-daily intravenous busulfan and fludarabine (Clinical and pharmacokinetic results of a myeloablative, reduced-toxicity conditioning regimen for allogeneic stem cell transplantation in AML and MDS) . Blood . 2004;104:857–864
-
.
Treatment of AML/MDS with allogeneic hematopoietic stem cell transplantation after intravenous busulfan-based conditioning therapy
.
Biol Blood Marrow Transplant Rev
. 2005;15:10–11
-
Outcomes of older patients with myeloid leukemias treated with myeloablative intravenous busulfan-based conditioning regimens and allogeneic blood or marrow transplantation
.
Blood
. 2005;106:660a;
(abstr)
- Hematopoietic stem-cell transplantation from unrelated donors in elderly patients (age >55 years) with hematologic malignancies (Older age is no longer a contraindication when using reduced intensity conditioning) . Leukemia . 2005;19:7–12
- . Myeloablative conditioning using IV busulfan reduces toxicity to the level observed in low-intensity conditioning regimens (dose does matter) . Biol Blood Marrow Transplant . 2005;15:8–9
- A decision analysis of allogeneic bone marrow transplantation for the myelodysplastic syndromes (Delayed transplantation for low-risk myelodysplasia is associated with improved outcome) . Blood . 2004;104:579–585
-
.
The Thompson/Luger article reviewed
.
Oncology
. 2005;19:542–543
-
.
Prospective feasibility analysis of reduced intensity conditioning regimens (RIC) for hematopoietic stem cell transplantation (HSCT) in elderly patients with AML and MDS
.
Blood
. 2005;106:2892a;
(abstr)
- . Pretransplantation induction chemotherapy and posttransplantation relapse in patients with advanced myelodysplastic syndrome . Biol Blood Marrow Transplant . 2005;11:65–73
- . Effects of aging on the homing and engraftment of murine hematopoietic stem and progenitor cells . Blood . 2005;106:1479–1487
-
.
DNA repair defects in stem cell function and aging
.
Annu Rev Med
. 2005;56:508
-
Influence of allele level HLA typing on unrelated donor (UD) transplantation for high-risk myeloid leukemias
.
Blood
. 2005;106:2916a;
(abstr)
- Limiting transplantation-related mortality following unrelated donor stem cell transplantation by using a nonmyeloablative conditioning regimen . Blood . 2002;99:1071–1078
- Fludarabine, melphalan, and alemtuzumab conditioning in adults with standard-risk advanced acute myeloid leukemia and myelodysplastic syndrome . J Clin Oncol . 2005;23:5728–5738
- . Reduced-intensity allogeneic hematopoietic stem cell transplantion for myelodysplastic syndrome and acute myeloid leukemia with multilineage dysplasia using fludarabine, busulfan and alemtuzumab (FBC) conditioning . Blood . 2004;104:1616–1623
- Reduced-intensity conditioning allogeneic blood stem cell transplantation with fludarabine and oral busulfan with or without pharmacokinetically targeted busulfan dosing in patients with myeloid leukemia ineligible for conventional conditioning . Biol Blood Marrow Transplant . 2005;11:437–447
- HLA-matched unrelated donor hematopoietic cell transplantation after nonmyeloablative conditioning for patients with hematologic malignancies . Blood . 2003;102:2021–2030
- . Allogeneic stem-cell transplantation from related and unrelated donors in older patients with myeloid leukemia . J Clin Oncol . 2003;21:1480–1484
- Ablative allogeneic hematopoietic cell transplantation in adults 60 years of age and older . J Clin Oncol . 2005;23:3439–3446
- . Hematopoietic cell transplantation from unrelated donors as an effective therapy for older patients (>= 60 years) with active myeloid malignancies (letter) . Blood . 2005;105:4147–4148
- Reduced-intensity conditioning for unrelated donor hematopoietic stem cell transplantation as treatment for myeloid malignancies in patients older than 55 years . Blood . 2003;102:3052–3059
- . Sequential regimen of chemotherapy, reduced-intensity conditioning for allogeneic stem-cell transplantation, and prophylactic donor-lymphocyte transfusion in high-risk acute myeloid leukemia and myelodysplastic syndrome . J Clin Oncol . 2005;23:5675–5687
PII: S0037-1963(06)00021-7
doi: 10.1053/j.seminhematol.2006.01.004
© 2006 Elsevier Inc. All rights reserved.
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Seminars in Hematology
Volume 43, Issue 2
, Pages 107-117
, April 2006
