Seminars in Hematology
Volume 43 , Pages S59-S63 , January 2006

Massive Transfusion Coagulopathy

  • Jerrold H. Levy

      Affiliations

    • Corresponding Author InformationAddress correspondence to Jerrold H. Levy, MD, Professor of Anesthesiology, Department of Anesthesiology, Emory University School of Medicine, Cardiothoracic Anesthesiology and Critical Care, Emory Healthcare, Atlanta, GA 30322.

References 

  1. Hardy JF , De Moerloose P , Samama M  Groupe d’interet en Hemostase Perioperatoire . Massive transfusion and coagulopathy (pathophysiology and implications for clinical management) . Can J Anaesth . 2004;51:293–310
  2. Toh CH , Dennis M . Disseminated intravascular coagulation (old disease, new hope) . BMJ . 2003;327:974–977
  3. Keel M , Trentz O . Pathophysiology of polytrauma . Injury . 2005;36:691–709
  4. Levy JH , Despotis GJ , Szlam F , Olson P , Meeker D , Weisinger A . Recombinant human transgenic antithrombin in cardiac surgery (A dose-finding study) . Anesthesiology . 2002;96:1095–1102
  5. Rinder CS , Bohnert J , Rinder HM , Mitchell J , Ault K , Hillman R . Platelet activation and aggregation during cardiopulmonary bypass . Anesthesiology . 1991;75:388–393
  6. Rohrer MJ , Natale AM . Effect of hypothermia on the coagulation cascade . Crit Care Med . 1992;20:1402–1405
  7. Miller RD , Robbins TO , Tong MJ , Barton SL . Coagulation defects associated with massive blood transfusions . Ann Surg . 1971;174:794–801
  8. Chu MW , Wilson SR , Novick RJ , Stitt LW , Quantz MA . Does clopidogrel increase blood loss following coronary artery bypass surgery? . Ann Thorac Surg . 2004;78:1536–1541
  9. van der Linden J , Lindvall G , Sartipy U . Aprotinin decreases postoperative bleeding and number of transfusions in patients on clopidogrel undergoing coronary artery bypass graft surgery (A double-blind, placebo-controlled, randomized clinical trial) . Circulation . 2005;112(suppl 9):I276–I280
  10. Hongo RH , Ley J , Dick SE , Yee RR . The effect of clopidogrel in combination with aspirin when given before coronary artery bypass grafting . J Am Coll Cardiol . 2002;40:231–237
  11. Yende S , Wunderink RG . Effect of clopidogrel on bleeding after coronary artery bypass surgery . Crit Care Med . 2001;29:2271–2275
  12. Lind SE . The bleeding time does not predict surgical bleeding . Blood . 1991;77:2547–2552
  13. Spiess BD , Royston D , Levy JH , Fitch J , Dietrich W , Body S , et al.  Platelet transfusions during coronary artery bypass graft surgery are associated with serious adverse outcomes . Transfusion . 2004;44:1143–1148
  14. Loskutoff DJ , Curriden SA . The fibrinolytic system of the vessel wall and its role in the control of thrombosis . Ann N Y Acad Sci . 1990;598:238–247
  15. Shinohara M , Kurokawa H , Yoshihara Y , Kokubu S , Kusano T , Horie K , et al.  Responses to surgical stress in blood coagulation and fibrinolysis, platelet counts and thromboxane B2 after esophageal cancer operation . Rinsho Byori . 1997;45:179–184
  16. Motta G , Rojkjaer R , Hasan AA , Cines DB , Schmaier AH . High molecular weight kininogen regulates prekallikrein assembly and activation on endothelial cells (A novel mechanism for contact activation) . Blood . 1998;91:516–528
  17. Becker EL . Stimulated neutrophil locomotion (chemokinesis and chemotaxis) . Arch Pathol Lab Med . 1977;101:509–513
  18. Rinder CS , Mathew JP , Rinder HM , Bonan J , Ault KA , Smith BR . Modulation of platelet surface adhesion receptors during cardiopulmonary bypass . Anesthesiology . 1991;75:563–570
  19. Collet JP , Montalescot G , Lesty C , Soria J , Mishal Z , Thomas D , et al.  Disaggregation of in vitro preformed platelet-rich clots by abciximab increases fibrin exposure and promotes fibrinolysis . Arterioscler Thromb Vasc Biol . 2001;21:142–148
  20. Lowe GD , Rumley A , Mackie IJ . Plasma fibrinogen . Ann Clin Biochem . 2004;41:430–440
  21. Kratz A , Lewandrowski KB . Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Normal reference laboratory values . N Engl J Med . 1998;339:1063–1072
  22. Meyer M . Molecular biology of haemostasis (Fibrinogen, factor XIII) . Hamostaseologie . 2004;24:108–115
  23. Hellgren M . Hemostasis during normal pregnancy and puerperium . Semin Thromb Hemost . 2003;29:125–130
  24. Kokoszka A , Kuflik P , Bitan F , Casden A , Neuwirth M . Evidence-based review of the role of aprotinin in blood conservation during orthopaedic surgery . J Bone Joint Surg Am . 2005;87:1129–1136
  25. Kinzel V , Shakespeare D , Derbyshire D . The effect of aprotinin on blood loss in bilateral total knee arthroplasty . Knee . 2005;12:107–111
  26. Levy JH . Efficacy and safety of aprotinin in cardiac surgery . Orthopedics . 2004;27(suppl 6):s659–s662
  27. Sedrakyan A , Treasure T , Elefteriades JA . Effect of aprotinin on clinical outcomes in coronary artery bypass graft surgery (A systematic review and meta-analysis of randomized clinical trials) . J Thorac Cardiovasc Surg . 2004;128:442–448
  28. Xia VW , Steadman RH . Antifibrinolytics in orthotopic liver transplantation (Current status and controversies) . Liver Transpl . 2005;11:10–18
  29. Levy JH , Pifarre R , Schaff HV , Horrow JC , Albus R , Spiess B , et al.  A multicenter, double-blind, placebo-controlled trial of aprotinin for reducing blood loss and the requirement for donor-blood transfusion in patients undergoing repeat coronary artery bypass grafting . Circulation . 1995;92:2236–2244
  30. Levi MM , Vink R , de Jonge E . Management of bleeding disorders by prohemostatic therapy . Int J Hematol . 2002;76(suppl 2):139–144
  31. Dunn CJ , Goa KL . Tranexamic acid (A review of its use in surgery and other indications) . Drugs . 1999;57:1005–1032
  32. Dobkowski WB , Murkin JM . A risk-benefit assessment of aprotinin in cardiac surgical procedures . Drug Saf . 1998;18:21–41
  33. Tanaka KA , Szlam F , Katori N , Vega JD , Levy JH . Evaluation of a novel kallikrein inhibitor on hemostatic activation in vitro . Thromb Res . 2004;113:333–339
  34. Levi M , Peters M , Buller HR . Efficacy and safety of recombinant factor VIIa for treatment of severe bleeding (A systematic review) . Crit Care Med . 2005;33:883–890
  35. von Heymann C , Hotz H , Konertz W , Kox WJ , Spies C . Successful treatment of refractory bleeding with recombinant factor VIIa after redo coronary artery bypass graft surgery . J Cardiothorac Vasc Anesth . 2002;16:615–616
  36. Hendriks HG , van der Maaten JM , de Wolf J , Waterbolk TW , Slooff MJ , van der Meer J . An effective treatment of severe intractable bleeding after valve repair by one single dose of activated recombinant factor VII . Anesth Analg . 2001;93:287–289
  37. Kastrup M , von Heymann C , Hotz H , Konertz WF , Ziemer S , Kox WJ , et al.  Recombinant factor VIIa after aortic valve replacement in a patient with osteogenesis imperfecta . Ann Thorac Surg . 2002;74:910–912
  38. Tanaka KA , Waly AA , Cooper WA , Levy JH . Treatment of excessive bleeding in Jehovah’s Witness patients after cardiac surgery with recombinant factor VIIa (NovoSeven) . Anesthesiology . 2003;98:1513–1515
  39. Stratmann G , Russell IA , Merrick SH . Use of recombinant factor VIIa as a rescue treatment for intractable bleeding following repeat aortic arch repair . Ann Thorac Surg . 2003;76:2094–2097
  40. Halkos ME , Levy JH , Chen E , Reddy VS , Lattouf OM , Guyton RA , et al.  Early experience with activated recombinant factor VII for intractable hemorrhage after cardiovascular surgery . Ann Thorac Surg . 2005;79:1303–1306
  41. Gowers CJ , Parr MJ . Recombinant activated factor VIIa use in massive transfusion and coagulopathy unresponsive to conventional therapy . Anaesth Intensive Care . 2005;33:196–200

PII: S0037-1963(05)00226-X

doi: 10.1053/j.seminhematol.2005.11.019

Seminars in Hematology
Volume 43 , Pages S59-S63 , January 2006