Seminars in Hematology
Volume 43 , Pages S37-S41 , January 2006

Congenital and Acquired Platelet Disorders: Current Dilemmas and Treatment Strategies

  • Gilbert C. White II

      Affiliations

    • Corresponding Author InformationAddress correspondence to G.C. White, MD, Blood Research Institute, 8727 Watertown Plank Rd, Milwaukee, WI 53226.

References 

  1. Alevriadou BR , Moake JL , Turner NA , Ruggeri ZM , Folie BJ , Phillips MD , et al.  Real-time analysis of shear-dependent thrombus formation and its blockade by inhibitors of von Willebrand factor binding to platelets . Blood . 1993;81:1263–1276
  2. Santoro SA , Zutter MM . The alpha2beta1 integrin (A collagen receptor on platelets and other cells) . Thromb Haemost . 1995;74:813–821
  3. Tsuji M , Ezumi Y , Arai M , Takayama H . A novel association of Fc receptor γ-chain with glycoprotein VI and their co-expression as a collagen receptor in human platelets . J Biol Chem . 1997;272:23528–23531
  4. Tandon NN , Kralisz U , Jamieson GA . Identification of glycoprotein IV (CD36) as a primary receptor for platelet-collagen adhesion . J Biol Chem . 1989;264:7576–7583
  5. Piotrowicz RS , Orchekowski RP , Nugent DJ , Yamada KY , Kunicki TJ . Glycoprotein Ic-IIa functions as an activation-independent fibronectin receptor on human platelets . J Cell Biol . 1988;106:1359–1364
  6. White GC . Platelet physiology and function . Blood Coagul Fibrinolysis . 2000;11(suppl 1):S53
  7. Smith W , Garavito RM , DeWitt DL . Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2 . J Biol Chem . 1996;271:33157–33160
  8. Fitzgerald GA . Mechanisms of platelet activation (Thromboxane A2 as an amplifying signal for other agonists) . Am J Cardiol . 1991;68:11B–15B
  9. Roth GJ , Stanford N , Majerus PW . Acetylation of prostaglandin synthase by aspirin . Proc Natl Acad Sci U S A . 1975;72:3073–3076
  10. Papp B , Enyedi A , Kovacs T , Sarkadi B , Wuytack F , Thastrup O , et al.  Demonstration of two forms of calcium pumps by thapsigargin inhibition and radioimmunoblotting in platelet membrane vesicles . J Biol Chem . 1991;266:14593–14596
  11. Dode L , Wuytack F , Kools PFJ , Baba-Aissa F , Raeymaekers L , Brik F , et al.  cDNA cloning, expression and chromosomal localization of the human sarco/endoplasmic reticulum CA2+-ATPase 3 gene . Biochem J . 1996;318:689–699
  12. Woodside DG , Liu S , Ginsberg MH . Integrin activation . Thromb Haemost . 2001;86:316–323
  13. George JN , Caen JP , Nurden AT . Glanzmann’s thrombasthenia (The spectrum of clinical disease) . Blood . 1990;75:1383–1395
  14. López JA , Andrews RK , Afshar-Khargan V , Berndt MC . Bernard-Soulier syndrome . Blood . 1998;91:4397–4418
  15. Di Castelnuovo A , de Gaetano G , Donati MB , Iacoviello L . Platelet glycoprotein receptor IIIa polymorphism PLA1/PLA2 and coronary risk (A meta-analysis) . Thromb Haemost . 2001;85:626–633
  16. Kritzik M , Savage B , Nugent DJ , Santoso S , Ruggeri ZM , Kunicki TJ . Nucleotide polymorphisms in the α2 gene define multiple alleles that are associated with differences in platelet α2β1 density . Blood . 1998;92:2382–2388
  17. Cramer EM , Vainchenker W , Vinci G , Guichard J , Breton-Gorius J . Gray platelet syndrome (Immunoelectron microscopic localization of fibrinogen and von Willebrand factor in platelets and megakaryocytes) . Blood . 1985;66:1309–1316
  18. Rosa JP , George JN , Bainton DF , Nurden AT , Caen JP , McEver RP . Gray platelet syndrome (Demonstration of α-granule membranes that can fuse with the cell surface) . J Clin Invest . 1987;80:1138–1146
  19. Drouin A , Favier R , Massé J-M , Debili N , Schmitt A , Elbim C , et al.  Newly recognized cellular abnormalities in the gray platelet syndrome . Blood . 2001;98:1382–1391
  20. Schmitt A , Jouault H , Guichard J , Wendling F , Drouin A , Cramer EM . Pathologic interaction between megakaryocytes and polymorphonuclear leukocytes in myelofibrosis . Blood . 2000;96:1342–1347
  21. Hirata T , Kakizuka A , Ushikubi F , Fuse I , Okuma M , Narumiya S . Arg60 to Leu mutation of the human thromboxane A2 receptor in a dominantly inherited bleeding disorder . J Clin Invest . 1994;94:1662–1667
  22. Hirata T , Ushikubi F , Kakizuka A , Okuma M , Narumiya S . Two thromboxane A2 receptor isoforms in human platelets. Opposite coupling to adenylyl cyclase with different sensitivity to Arg60 to Leu mutation . J Clin Invest . 1996;97:949–956
  23. Poon M-C , D’Oiron R , Von Depka M , Khair K , Négrier C , Karafoulidou A , et al.  Prophylactic and therapeutic recombinant factor VIIa administration to patients with Glanzmann’s thrombasthenia (Results of an international survey) . J Thromb Haemost . 2004;2:1096–1103
  24. Levi M , Peters M , Büller HR . Efficacy and safety of recombinant factor VIIa for treatment of severe bleeding (A systematic review) . Crit Care Med . 2005;33:883–890
  25. Monroe DM , Hoffman M , Oliver JA , Roberts HR . Platelet activity of high-dose factor VIIa is independent of tissue factor . Br J Haematol . 1997;99:542–547
  26. Antovic JP , Antovic A . Does recombinant factor VIIa, apart from overall hemostasis, regulate TAFI dependent fibrinolysis? In vitro analysis using overall hemostasis potential (OHP) assay . Thromb Haemost . 2003;90:620–627

PII: S0037-1963(05)00218-0

doi: 10.1053/j.seminhematol.2005.11.011

Seminars in Hematology
Volume 43 , Pages S37-S41 , January 2006

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