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Seminars in Hematology
Volume 43, Issue 1
, Pages 62-69
, January 2006
CD4+CD25+ Regulatory T Cells and Graft-Versus-Host Disease
References
- . The history and future of T-cell depletion as graft-versus-host disease prophylaxis for allogeneic hematopoietic stem cell transplantation . Blood . 2001;98:3192–3204
- . The thymus and negative selection . Immunol Rev . 2002;185:126–135
- Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide . J Immunol . 1994;152:5581–5592
- . Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses . Annu Rev Immunol . 2004;22:531–562
- . Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases . J Immunol . 1995;155:1151–1164
- . Natural regulatory T cells in infectious disease . Nat Immunol . 2005;6:353–360
- . Immunoregulatory T cells in tumor immunity . Curr Opin Immunol . 2004;16:157–162
- . Regulatory T cells and organ transplantation . Semin Immunol . 2004;16:119–126
- Role of LAG-3 in regulatory T cells . Immunity . 2004;21:503–513
- Neuropilin-1 (A surface marker of regulatory T cells) . Eur J Immunol . 2004;34:623–630
- Murine CD4+CD25+ regulatory T cells fail to undergo chromatin remodeling across the proximal promoter region of the IL-2 gene . J Immunol . 2004;173:4994–5001
- Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells . J Immunol . 2004;172:5287–5296
- . Tolerance, not immunity, crucially depends on IL-2 . Nat Rev Immunol . 2004;4:665–674
- . Regulatory CD4 T cells control the size of the peripheral activated/memory CD4 T cell compartment . J Immunol . 2000;164:3573–3580
- Continuous activation of autoreactive CD4+ CD25+ regulatory T cells in the steady state . J Exp Med . 2003;198:737–746
- . In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro . Proc Natl Acad Sci U S A . 2003;100:8886–8891
- . CD4+ CD25+ suppressor T cells (More questions than answers) . Nat Rev Immunol . 2002;2:389–400
- . Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta . J Exp Med . 2001;194:629–644
- Suppressive properties of human CD4+CD25+ regulatory T cells are dependent on CTLA-4 expression . Eur J Immunol . 2004;34:3485–3496
- . Distinct roles of CTLA-4 and TGF-beta in CD4+CD25+ regulatory T cell function . Eur J Immunol . 2004;34:2996–3005
- Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo . Proc Natl Acad Sci U S A . 2005;102:419–424
- . A well adapted regulatory contrivance (Regulatory T cell development and the forkhead family transcription factor Foxp3) . Nat Immunol . 2005;6:331–337
- . CD4+CD25+ regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cells . Eur J Immunol . 2000;30:1538–1543
- . Cutting edge (Human CD4+CD25+ T cells restrain the maturation and antigen-presenting function of dendritic cells) . J Immunol . 2004;172:4676–4680
- Modulation of tryptophan catabolism by regulatory T cells . Nat Immunol . 2003;4:1206–1212
- Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse . Nat Genet . 2001;27:68–73
- . Foxp3 programs the development and function of CD4+CD25+ regulatory T cells . Nat Immunol . 2003;4:330–336
- . An essential role for Scurfin in CD4+CD25+ T regulatory cells . Nat Immunol . 2003;4:337–342
- . Control of regulatory T cell development by the transcription factor Foxp3 . Science . 2003;299:1057–1061
- Phenotype, localization, and mechanism of suppression of CD4(+)CD25(+) human thymocytes . J Exp Med . 2002;196:379–387
- . Regulatory CD4 T cells (Expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency) . Int Immunol . 1998;10:371–378
- . Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self . Nat Immunol . 2005;6:345–352
- Analysis of FOXP3 protein expression in human CD4(+)CD25(+) regulatory T cells at the single-cell level . Eur J Immunol . 2005;35:1681–1691
- . Human CD4+CD25+ regulatory T cells . Semin Immunol . 2004;16:89–98
- . Regulatory T cell lineage specification by the forkhead transcription factor foxp3 . Immunity . 2005;22:329–341
- . Single cell analysis shows decreasing FoxP3 and TGFbeta1 coexpressing CD4+CD25+ regulatory T cells during autoimmune diabetes . J Exp Med . 2005;201:1333–1346
- . Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4(+)25(+) immunoregulatory T cells . J Exp Med . 2001;194:427–438
- Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide . Nat Immunol . 2001;2:301–306
- . Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells . J Exp Med . 2004;200:1221–1230
- . Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells . Proc Natl Acad Sci U S A . 2005;102:5138–5143
- . Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation . J Exp Med . 2002;196:389–399
- . CD4(+)CD25(+) immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade . J Exp Med . 2001;193:1311–1318
- . Post-hematopoietic cell transplantation control of graft-versus-host disease by donor CD4(+)25(+) T cells to allow an effective graft-versus-leukemia response . Biol Blood Marrow Transplant . 2003;9:243–256
- CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation . Nat Med . 2003;9:1144–1150
- . Donor CD4+CD25+ T cells promote engraftment and tolerance following MHC-mismatched hematopoietic cell transplantation . Blood . 2005;105:1828–1836
- . Induction of antigen-specific tolerance to bone marrow allografts with CD4+CD25+ T lymphocytes . Blood . 2004;103:4216–4221
- Recipient-type specific CD4+CD25+ regulatory T cells favor immune reconstitution and control graft-versus-host disease while maintaining graft-versus-leukemia . J Clin Invest . 2003;112:1688–1696
- . CD4(+)CD25(+) immunoregulatory T Cells (New therapeutics for graft-versus-host disease) . J Exp Med . 2002;196:401–406
- . The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality . Blood . 2002;99:3493–3499
- . Tracking ex vivo-expanded CD4+CD25+ and CD8+CD25+ regulatory T cells after infusion to prevent donor lymphocyte infusion-induced lethal acute graft-versus-host disease . Biol Blood Marrow Transplant . 2004;10:748–760
- . Suppressor activity of anergic T cells induced by IL-10-treated human dendritic cells (association with IL-2- and CTLA-4-dependent G1 arrest of the cell cycle regulated by p27Kip1) . Eur J Immunol . 2003;33:1988–1997
- Acute graft-versus-host disease does not require alloantigen expression on host epithelium . Nat Med . 2002;8:575–581
- Prevention of graft versus host disease by inactivation of host antigen-presenting cells . Science . 1999;285:412–415
- Peyer’s patch is the essential site in initiating murine acute and lethal graft-versus-host reaction . Nat Immunol . 2003;4:154–160
- Delaying acute graft-versus-host disease in mouse bone marrow transplantation by treating donor cells with antibodies directed at L-selectin and alpha4-integrin prior to infusion . Scand J Immunol . 2004;59:464–468
- Memory CD4+ T cells do not induce graft-versus-host disease . J Clin Invest . 2003;112:101–108
- . Transfer of allogeneic CD62L- memory T cells without graft-versus-host disease . Blood . 2004;103:1534–1541
- Only the CD62L+ subpopulation of CD4+CD25+ regulatory T cells protects from lethal acute GVHD . Blood . 2005;105:2220–2226
- . The subpopulation of CD4+CD25+ splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7 . J Immunol . 2002;169:2461–2465
- L-Selectin(hi) but not the L-selectin(lo) CD4+25+ T-regulatory cells are potent inhibitors of GVHD and BM graft rejection . Blood . 2004;104:3804–3812
- . Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific . J Immunol . 2000;164:183–190
- . CD4+CD25+ cells controlling a pathogenic CD4 response inhibit cytokine differentiation, CXCR-3 expression, and tissue invasion . J Immunol . 2004;173:2942–2951
- Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells . J Exp Med . 2004;199:303–313
- Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4(+)CD25(+) regulatory T cells . J Exp Med . 2001;194:847–853
- Chemokine receptor expression and function in CD4+ T lymphocytes with regulatory activity . J Immunol . 2001;166:996–1002
- Donor leukocyte transfusions for treatment of recurrent chronic myelogenous leukemia in marrow transplant patients . Blood . 1990;76:2462–2465
- Factors predicting response and graft-versus-host disease after donor lymphocyte infusions (A study on 593 infusions) . Bone Marrow Transplant . 2003;31:687–693
- . Principles of graft-vs.-leukemia reactivity . Biol Blood Marrow Transplant . 1995;1:61–68
- . Properties of purified T cell subsets. II. In vivo responses to class I vs. class II H-2 differences . J Exp Med . 1986;163:998–1011
- . Pathogenesis of acute graft-versus-host disease (Cytokines and cellular effectors) . J Hematother Stem Cell Res . 2000;9:299–306
- CD25 expression on donor CD4+ or CD8+ T cells is associated with an increased risk for graft-versus-host disease after HLA-identical stem cell transplantation in humans . Blood . 2004;103:1140–1146
- Kinetic of regulatory CD25high and activated CD134+ (OX40) T lymphocytes during acute and chronic graft-versus-host disease after allogeneic bone marrow transplantation . Br J Haematol . 2004;126:697–703
- Chronic graft-versus-host disease is associated with increased numbers of peripheral blood CD4+CD25high regulatory T cells . Blood . 2004;103:2410–2416
- Association of Foxp3 regulatory gene expression with graft-versus-host disease . Blood . 2004;104:2187–2193
- Evaluation of a CD25-specific immunotoxin for prevention of graft-versus-host disease after unrelated marrow transplantation . Biol Blood Marrow Transplant . 2004;10:552–560
- In vitro-expanded human CD4(+)CD25(+) T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures . Blood . 2004;104:453–461
- . Large-scale in vitro expansion of polyclonal human CD4(+)CD25high regulatory T cells . Blood . 2004;104:895–903
- . Induction of allopeptide-specific human CD4+CD25+ regulatory T cells ex vivo . Blood . 2003;102:2180–2186
PII: S0037-1963(05)00172-1
doi: 10.1053/j.seminhematol.2005.09.006
© 2006 Elsevier Inc. All rights reserved.
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Seminars in Hematology
Volume 43, Issue 1
, Pages 62-69
, January 2006
