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Seminars in Hematology
Volume 42, Issue 4
, Pages 181-183
, October 2005
Chronic Myeloproliferative Disorders—Introduction
References
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Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
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Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders
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- The JAK2 V617F activating tyrosine kinase mutation is an infrequent event in both “atypical” myeloproliferative disorders and the myelodysplastic syndrome . Blood . 2005;106:1207–1209
- Gene expression profiling in polycythaemia vera (overexpression of transcription factor NF-E2) . Br J Haematol . 2005;129:138–150
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JAK2 mutation 1849G→T is rare in acute leukemias but can be found in CMML, Philadelphia-chromosome negative CML and megakaryocytic leukemia
.
Blood
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Jul 21 [Epub ahead of print]
-
The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia
.
Blood
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Aug 4 [Epub ahead of print]
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Altered gene expression in myeloproliferative disorders correlates with activation of signaling by the V617F mutation of Jak2
.
Blood
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Aug 4 [Epub ahead of print]
PII: S0037-1963(05)00146-0
doi: 10.1053/j.seminhematol.2005.08.004
© 2005 Elsevier Inc. All rights reserved.
« Previous
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Seminars in Hematology
Volume 42, Issue 4
, Pages 181-183
, October 2005
