Seminars in Hematology
Volume 42, Issue 3 , Pages 165-168 , July 2005

Pathophysiology of Hemolytic Transfusion Reactions

  • Robertson D. Davenport

      Affiliations

    • Corresponding Author InformationAddress correspondence to Robertson Davenport, MD, Department of Pathology, The University of Michigan Medical School, University Hospital 2G332/0054, 1500 E Medical Center Dr, Ann Arbor, MI 48109-0054.

References 

  1. Ruegg SJ , Jungi TW . Antibody-mediated erythrolysis and erythrophagocytosis by human monocytes, macrophages and activated macrophages. Evidence for distinction between involvement of high-affinity and low-affinity receptors for IgG by using different erythroid target cells . Immunology . 1988;63:513–520
  2. Leslie RGQ . Immunoglobulin and soluble immune complex binding to phagocyte Fc receptors . Biochem Soc Trans . 1984;12:743–746
  3. Davenport RD , Kunkel SL . IgG receptor roles in red cell binding to monocytes and macrophages . Transfusion . 1994;34(suppl):79S; (abstr)
  4. Unkeless JC . Function and heterogeneity of human Fc receptors for immunoglobulin G . J Clin Invest . 1989;83:355–361
  5. Clarkson SB , Kimberly RP , Valinsky JE , Witmer MD , Bussel JB , Nachman RL , et al.   Blockade of clearance of immune complexes by anti-Fc gamma receptor monoclonal antibody . J Exp Med . 1986;164:474–489
  6. Butler J , Parker D , Pillai R , Shale DJ , Rocker GM . Systemic release of neutrophil elastase and tumour necrosis factor alpha following ABO incompatible blood transfusion . Br J Haematol . 1991;79:525–526
  7. Davenport RD , Strieter RM , Kunkel SL . Red Cell ABO Incompatibility and production of tumour necrosis factor-alpha . Br J Haematol . 1991;78:540–544
  8. Davenport RD , Kunkel SL . Leukocyte procoagulant activity induced by ABO incompatibility . Transfusion . 1992;34(suppl):53S; (abstr)
  9. Davenport RD , Burdick M , Kunkel SL . Endothelial cell activation in hemolytic transfusion reactions . Transfusion . 1992;34(suppl):53S; (abstr)
  10. Davenport RD , Strieter RM , Standiford TJ , Kunkel SL . Interleukin-8 production in red blood cell incompatibility . Blood . 1990;76:2439–2442
  11. Davenport RD , Burdick MD , Strieter RM , Kunkel SL . Monocyte chemoattractant protein production in red cell incompatibility . Transfusion . 1994;34:16–19
  12. Davenport RD , Burdick M , Moore SA , Kunkel SL . Cytokine production in IgG mediated red cell incompatibility . Transfusion . 1993;33:19–24
  13. Hoffman M . Antibody-coated erythrocytes induce secretion of tumor necrosis factor by human monocytes (A mechanism for the production of fever by incompatible transfusions) . Vox Sang . 1991;60:184–187
  14. Von Zabern I , Ehlers M , Grunwald U , Mauemann K , Greinacher A . Release of mediators of systemic inflammatory response syndrome in the course of a severe delayed hemolytic transfusion reaction caused by anti-D . Transfusion . 1998;38:459–468
  15. Davenport RD , Burdick MD , Strieter RM , Kunkel SL . In vitro production of Interleukin-1 receptor antagonist in IgG mediated red cell incompatibility . Transfusion . 1994;34:297–303
  16. Coopamah MD , Freedman J , Semple JW . Anti-D initially stimulates and Fc-dependent leukocyte oxidative burst and subsequently suppresses erythrophagocytosis via interleukin-1 receptor antagonist . Blood . 2003;102:2862–2867
  17. Davenport RD , Polak TJ , Kunkel SL . White cell-associated procoagulant activity induced by ABO incompatibility . Transfusion . 1994;34:934–949
  18. Hillmen P , Hall C , Marsh JCW , et al.   Effect of eculizumab on hemolysis and transfusion requirements in patients with paroxysmal nocturnal hemoglobinuria . N Engl J Med . 2004;350:552–559
  19. Panacek EA , Marshall JC , Albertson TE , et al.   Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab′)2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels . Crit Care Med . 2004;32:2173–2182

PII: S0037-1963(05)00059-4

doi: 10.1053/j.seminhematol.2005.04.006

Seminars in Hematology
Volume 42, Issue 3 , Pages 165-168 , July 2005

Article Tools

* Image Usage & Resolution