Seminars in Hematology
Volume 42, Issue 2 , Pages 76-84 , April 2005

Human leukocyte antigen matching in unrelated donor hematopoietic cell transplantation

  • Effie W. Petersdorf

      Affiliations

    • Corresponding Author InformationAddress correspondence to Effie W. Petersdorf, MD, Fred Hutchinson Cancer Research Center, Division of Clinical Research, D4-100, 1100 Fairview Ave N, Seattle, WA 98109
    • ,
  • Mari Malkki

References 

  1. Price P , Witt C , Allcock R , Sayer D , Garlepp M , Kok CC , et al.   The genetic basis for the association of the 8.1 ancestral haplotype (A1, B8, DR3) with multiple immunological diseases . Immunol Rev . 1999;167:257–274
  2. Marsh SGE , Albert ED , Bodmer WF , Bontrop RE , Dupont B , Erlich HA , et al.   Nomenclature for factors of the HLA system, 2002 . Eur J Immunol . 2002;29:463–517
  3. The MHC Sequencing Consortium . Complete sequence and gene map of a human major histocompatibility complex . Nature . 1999;401:921–923
  4. National Institutes of Health (NIH lymphocyte microcytotoxicity technique, in NIAID Manual of Tissue Typing Techniques (Publication No. NIH 80–545)) . Atlanta, GA: Department of Health, Education, and Welfare; 1979;
  5. Schreuder GM , Hurley CK , Marsh SG , Lau M , Maiers M , Kollman C , et al.   The HLA dictionary 1999 (A summary of HLA-A, -B, -C, -DRB1/3/4/5, -DQB1 alleles and their association with serologically-defined HLA-A, -B, -C, -DR, and -DQ antigens) . Hum Immunol . 1999;60:1157–1181
  6. Hurley CK , Setterholm M , Lau M , Pollack MS , Norreen H , Howard A , et al.   Hematopoietic stem cell donor registry strategies for assigning search determinants and matching relationships . Bone Marrow Transplant . 2004;33:443–450
  7. Goldman JM . Chronic myeloid leukemia . Curr Opin Hematol . 1997;4:277–285
  8. Cornelissen JJ , Carston M , Kollman C , King R , Dekker AW , Lowenberg B , et al.   Unrelated marrow transplantation for adult patients with poor-risk acute lymphoblastic leukemia (Strong graft-versus-leukemia effect and risk factors determining outcome) . Blood . 2001;97:1572–1577
  9. Ringdén O , Schaffer M , Le Blanc K , Hauzenberger D , Abedi MR , Olerup O , et al.   Which donor should be chosen for hematopoietic stem cell transplantation among unrelated HLA-A, -B, and –DRB1 genomically identical volunteers? . Biol Blood Marrow Transplant . 2004;10:128–134
  10. Deeg HJ , Storer B , Slattery JT , Anasetti C , Doney KC , Hansen JA , et al.   Conditioning with targeted busulfan and cyclophosphamide for hemopoietic stem cell transplantation from related and unrelated donors in patients with myelodysplastic syndrome . Blood . 2002;100:1201–1207
  11. Hansen JA , Gooley T , Martin PJ , Appelbaum F , Chauncey TR , Clift RA , et al.   Bone marrow transplants from unrelated donors for patients with chronic myeloid leukemia . N Engl J Med . 1998;338:962–968
  12. Sierra J , Radich J , Hansen JA , Martin PJ , Petersdorf EW , Bjerke J , et al.   Marrow transplants from unrelated donors for treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia . Blood . 1997;90:1410–1414
  13. Marks DI , Cullis JO , Ward KN , Lacey S , Szydlo R , Hughes TP , et al.   Allogeneic bone marrow transplantation for chronic myelogenous leukemia using sibling and volunteer unrelated donors (A comparison of complications in the first 2 years) . Ann Intern Med . 1993;119:207–212
  14. Kodera Y , Morishima Y , Kato S , Sao H , Matsuyama T , Kawa K , et al.   Analysis of 500 bone marrow transplants from unrelated donors (UR-BMT) facilitated by the Japan Marrow Donor Program (Confirmation of UR-BMT as a standard therapy for patients with leukemia and aplastic anemia) . Bone Marrow Transplant . 1999;24:995–1003
  15. McGlave PB , Shu XO , Wen W , Anasetti C , Nademanee A , Champlin R , et al.   Unrelated donor marrow transplantation for chronic myelogenous leukemia (9 years’ experience of the National Marrow Donor Program) . Blood . 2000;95:2219–2225
  16. Morishima Y , Sasazuki T , Inoko H , Juji T , Akaza T , Yamamoto K , et al.   The clinical significance of human leukocyte antigen (HLA) allele compatibility in patients receiving a marrow transplant from serologically HLA-A, HLA-B and HLA-Dr matched unrelated donors . Blood . 2002;99:4200–4206
  17. Anasetti C , Amos D , Beatty PG , Appelbaum FR , Bensinger W , Buckner CD , et al.   Effect of HLA compatibility on engraftment of bone marrow transplants in patients with leukemia or lymphoma . N Engl J Med . 1989;320:197–204
  18. Fleischhauer K , Kernan NA , O’Reilly RJ , Dupont B , Yang SY . Bone marrow-allograft rejection by T lymphocytes recognizing a single amino acid difference in HLA-B44 . N Engl J Med . 1990;323:1818–1822
  19. Davies SM , Shu XO , Blazar BR , Flipovich AH , Kersey JH , Kirvit W , et al.   Unrelated donor bone marrow transplantation (influence of HLA-A and -B incompatibility on outcome) . Blood . 1995;86:1636–1642
  20. Nademanee A , Schmidt GM , Parker P , Dagis AC , Stein A , Snyder DS , et al.   The outcome of matched unrelated donor bone marrow transplantation in patients with hematological malignancies using molecular typing for donor selection and graft-versus-host disease prophylaxis regimen of cyclosporine, methotrexate, and prednisone . Blood . 1995;86:1228–1234
  21. Petersdorf EW , Longton GM , Anasetti C , Martin PJ , Mickelson EM , Smith AG , et al.   The significance of HLA-DRB1 matching on clinical outcome after HLA-A, B, DR identical unrelated donor marrow transplantation . Blood . 1995;86:1606–1613
  22. Spencer A, Szydlo RM, Brookes PA, Kaminski E, Rule S, van Rhee F, et al  Bone marrow transplantation for chronic myeloid leukemia with volunteer unrelated donors using ex vivo or in vivo T-cell depletion (Major prognostic impact of HLA class I identity between donor and recipient) . Blood . 1995;86:3590–3597
  23. Nagler A , Brautbar C , Slavin S , Bishara A . Bone marrow transplantation using unrelated and family related donors (The impact of HLA-C disparity) . Bone Marrow Transplant . 1996;18:891–897
  24. Petersdorf EW , Longton GM , Anasetti C , Mickelson EM , Smith AG , Martin PJ , et al.   Definition of HLA-DQ as a transplantation antigen . Proc Natl Acad Sci U S A . 1996;93:15358–15363
  25. Speiser DE , Tiercy JM , Rufer N , Grundschober G , Gratwohl A , Chapuis C , et al.   High resolution HLA matching associated with decreased mortality after unrelated bone marrow transplantation . Blood . 1996;87:4455–4462
  26. Gajewski J , Gjertson D , Cecka M , Tonai R , Przepiorka D , Hunt L , et al.   The impact of T-cell depletion on the effects of HLA-DRB1 and DQB allele matching in HLA serologically identical unrelated donor bone marrow transplantation . Biol Blood Marrow Transplant . 1997;3:76–82
  27. Petersdorf EW , Longton GM , Anasetti C , Mickelson EM , McKinney SK , Smith AG , et al.   Association of HLA-C disparity with graft failure after marrow transplantation from unrelated donors . Blood . 1997;89:1818–1823
  28. Petersdorf EW , Gooley TA , Anasetti C , Martin PJ , Smith AG , Mickelson E , et al.   Optimizing outcome after unrelated marrow transplantation by comprehensive matching of HLA class I and II alleles in the donor and recipient . Blood . 1998;92:3515–3520
  29. Sasazuki T , Juji T , Morishima Y , Kinukawa N , Kashiwabara H , Inoko H , et al.   Effect of matching of class I HLA alleles on clinical outcome after transplantation of hematopoietic stem cells from an unrelated donor . N Engl J Med . 1998;339:1177–1185
  30. Varney MD , Lester S , McCluskey J , Gao X , Tait BD . Matching for HLA DPA1 and DPB1 alleles in unrelated bone marrow transplantation . Hum Immunol . 1999;60:532–538
  31. Davies SM , Kollman C , Anasetti C , Antin JH , Gajawski J , Casper JT , et al.   Engraftment and survival after unrelated-donor bone marrow transplantation (A report from the National Marrow Donor Program) . Blood . 2000;96:4096–4102
  32. Prezpiorka D , Saliba R , Cleary K , Fischer H , Tonai R , Fritsche H , et al.   Tacrolimus does not abrogate the increased risk of acute graft-versus-host disease after unrelated-donor marrow transplantation with allelic mismatching at HLA-DRB1 and HLA-DQB1 . Biol Blood Marrow Transplant . 2000;6:190–197
  33. Ferrara GB , Bacigalupo A , Lamparelli T , Lanino E , Delfino L , Morabito A , et al.   Bone marrow transplantation from unrelated donors (the impact of mismatches with substitutions at position 116 of the human leukocyte antigen class I heavy chain) . Blood . 2001;98:3150–3155
  34. Keever-Taylor CA , Bredeson C , Loberiza FR , Casper JT , Lawton C , Rizzo D , et al.   Analysis of risk factors for the development of GVHD after T cell-depleted allogeneic BMT (Effect of HLA disparity, ABO incompatibility, and method of T-cell depletion) . Biol Blood Marrow Transplant . 2001;7:620–630
  35. Petersdorf EW , Gooley T , Malkki M , Anasetti C , Martin P , Woolfrey A , et al.   The biological significance of HLA-DP gene variation in haematopoietic cell transplantation . Br J Haematol . 2001;112:988–994
  36. Petersdorf EW , Hansen JA , Martin PJ , Woolfrey A , Malkki M , Gooley T , et al.   Major histocompatibility complex class I alleles and antigens in hematopoietic cell transplantation . N Engl J Med . 2001;345:1794–1800
  37. Petersdorf EW , Kollman C , Hurley CK , Dupont B , Nademanee A , Begovich AB , et al.   Effect of HLA class II gene disparity on clinical outcome in unrelated donor hematopoietic cell transplantation for chronic myeloid leukemia (The US National Marrow Donor Program Experience) . Blood . 2001;98:2922–2929
  38. Van der Meer A , Allebes WA , Paarkekoopr J , Ruiter J , Joosten I . HLA-C mismatches induce strong cytotoxic T-cell reactivity in the presence of an additional DRB/DQB mismatch and affect NK cell-mediated alloreactivity . Transplant . 2001;72:923–929
  39. Barker JN , Davies SM , DeFor TE , Burns LJ , McGlave PB , Miller JS , et al.   Determinants of survival after human leucocyte antigen-matched unrelated donor bone marrow transplantation in adults . Brit J Haematol . 2002;118:101–107
  40. Schaffer M , Aldener-Cannavá A , Remberger M , Ringdén O , Olerup O . Roles of HLA-B, HLA-C and HLA-DPA1 incompatibilities in the outcome of unrelated stem-cell transplantation . Tissue Antigens . 2003;2:243–250
  41. Shaw BE , Potter MN , Mayor NP , Pay AL , Smith C , Goldman JM , et al.   The degree of matching at HLA-DPB1 predicts for acute graft-versus-host disease and disease relapse following haematopoietic stem cell transplantation . Bone Marrow Transplant . 2003;31:1001–1008
  42. Caillat-Zucman S , Le Deist F , Haddad E , Gannagé M , Dal Cortivo L , Jabado N , et al.   Impact of HLA matching on outcome of hematopoietic stem cell transplantation in children with inherited diseases (A single-center comparative analysis of genoidentical, haploidentical or unrelated donors) . Bone Marrow Transplant . 2004;33:1089–1095
  43. Flomenberg N , Baxter-Lowe LE , Confer D , Fernandez-Vina M , Filipovich A , Horowitz M , et al.   Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation (HLA-C mismatching is associated with a strong adverse effect on transplantation outcome) . Blood . 2004;104:1923–1930
  44. Gallardo D , Brunet S , Torres A , Alonso-Nieto M , Vallejo C , Jiménez A , et al.   HLA-DPB1 mismatch in HLA-A-B-DRB1 identical sibling donor stem cell transplantation and acute graft-versus-host disease . Transplant . 2004;77:1107–1110
  45. Petersdorf EW , Anasetti C , Martin PJ , Gooley T , Radich J , Malkki M , et al.   Limits of HLA mismatching in unrelated hematopoietic cell transplantation . Blood . 2004;104:2976–2980
  46. Tiercy J-M , Passweg J , van Biezen A , Zander A , Kröger N , Gratwohl A , et al.   Isolated HLA-C mismatches in unrelated donor transplantation for CML . Bone Marrow Transplant . 2004;34:249–255
  47. Baker SK , Gurney JG , Ness KK , Bhatia R , Forman SJ , Francisco L , et al.   Late effects in survivors of chronic myeloid leukemia treated with hematopoietic cell transplantation (Results from the Bone Marrow Transplant Survivor Study) . Blood . 2004;104:1898–1906
  48. Stewart BL , Storer B , Storek J , Deeg HJ , Storb R , Hansen JA , et al.   Duration of immunosuppressive treatment for chronic graft-versus-host disease . Blood . 2004;104:3501–3506
  49. Sierra J , Storer B , Hansen JA , Martin PJ , Petersdorf EW , Woolfrey A , et al.   Unrelated donor marrow transplantation for acute myeloid leukemia (An update of the Seattle experience) . Bone Marrow Transplant . 2000;26:397–404
  50. Kato Y , Mitsuishi Y , Cecka M , Hopfield J , Hunt L , Champlin R , et al.   HLA-DP incompatibilities and severe graft-versus-host disease in unrelated bone marrow transplants . Transplant . 1991;52:374–376
  51. Loiseau P , Espérou H , Busson M , Sghiri R , Tamouza R , Hilarius M , et al.   DPB1 disparities contribute to severe GVHD and reduced patient survival after unrelated donor bone marrow transplantation . Bone Marrow Transplant . 2002;30:497–502
  52. Zino E , Frumento G , Marktel S , Sormani MP , Ficara F , Di Terlizzi S , et al.   A T-cell epitope encoded by a subset of HLA-DPB1 alleles determines nonpermissive mismmatches for hematologic stem cell transplantation . Blood . 2004;103:1417–1424
  53. Begovich AB , McClure GR , Suraj VC , Helmuth RC , N Fildes TL , Bugawan HA , et al.   Polymorphism, recombination, and linkage disequilibrium within the HLA class II region . J Immunol . 1992;148:249–258
  54. Dini G , Grazia Valsecchi M , Micalizzi C , Busca A , Balduzzi A , Arcese W , et al.   Impact of marrow unrelated donor search duration on outcome of children with acute lymphoblastic leukemia in second remission . Bone Marrow Transplant . 2003;32:325–331
  55. Hughes TP , Kaeda J , Branford S , et al.   Frequency of major molecular responses to imatinib of interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia . N Engl J Med . 2003;349:1421–1430
  56. Drobyski WR , Klein J , Flomenberg N , Pietryga D , Vesole DH , Margolis DA , et al.   Superior survival associated with transplantation of matched unrelated versus one-antigen-mismatched unrelated or highly leukocyte antigen-disparate haploidentical family donor marrow grafts for the treatment of hematologic malignancies (Establishing a treatment algorithm for recipients of alternative donor grafts) . Blood . 2002;99:806–814
  57. Kanda Y , Chiba S , Hirai H , Sakamaki H , Iseki T , Kodera Y , et al.   Allogeneic hematopoietic stem cell transplantation from family members other than HLA-identical siblings over the last decade (1991–2000) . Blood . 2003;102:1541–1547
  58. Kiehl MG , Kraut L , Schwerdtfeger R , Hertenstein B , Remberger M , Kroeger N , et al.   Outcome of allogeneic hematopoietic stem-cell transplantation in adult patients with acute lymphoblastic leukemia (No difference in related compared with unrelated transplant in first complete remission) . J Clin Oncol . 2004;22:2816–2825
  59. Elsner HA , DeLuca D , Strub J , Blasczyk  . HistoCheck (Rating of HLA class I and II mismatches by an internet-based software tool) . Bone Marrow Transplant . 2004;33:165–169
  60. Proceedings of the 13th International Histocompatibility Workshop and Congress Petersdorf EW , Gooley T , Malkki M , Horowitz M . for the IHWG in HCT (Impact of donor-recipient HLA matching on survival after myeloablative heamtopoietic cell transplantation from unrelated donors) . In:  Hansen J ,  Dupont B editor. HLA 2004 (Immunobiology of the Human MHC) . Seattle, WA: IHWG Press; 2004;
  61. Hurley CK , Baxter Lowe LA , Logan B , Karanes C , Anasetti C , Wiesdorf D , et al.   National Marrow Donor Program HLA-matching guidelines for unrelated marrow transplants . Biol Blood Marrow Transplant . 2003;9:610–615
  62. Hurley CK , Raffoux C . on behalf of the World Marrow Donor Association (World Marrow Donor Association: International standards for unrelated hematopoietic stem cell donor registries) . Bone Marrow Transplant . 2004;34:103–110
  63. Wiegand T , Raffoux C , Hurley CK , Kern M , Oudshoorn M , Raymond J , et al.   A special report (suggested procedures for international unrelated donor search from the donor registries and quality assurance working groups of the World Marrow Donor Association (WMDA)) . Bone Marrow Transplant . 2004;34:97–101

 Supported by Grants CA18029, CA100019, and AI33484 from the National Institutes of Health (E.W.P.); and by Grants CA18029 and AI33484 from the National Institutes of Health, and from the Amy Strelzer Manasevit Scholars Program, National Marrow Donor Program (M.M.).

PII: S0037-1963(05)00009-0

doi: 10.1053/j.seminhematol.2005.01.009

Seminars in Hematology
Volume 42, Issue 2 , Pages 76-84 , April 2005

Article Tools

* Image Usage & Resolution