Seminars in Hematology
Volume 42, Issue 2 , Pages 104-111, April 2005

The effect of noninherited maternal antigens in allogeneic transplantation

  • J.J. van Rood

      Affiliations

    • Europdonor Foundation, Leiden, The Netherlands
    • Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    • Corresponding Author InformationAddress correspondence to J. J. van Rood, MD, PhD, Europdonor Foundation, Plesmanlaan 1b, 2333 BZ, Leiden, The Netherlands
    • ,
  • D.L. Roelen

      Affiliations

    • Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    • ,
  • F.H.J. Claas

      Affiliations

    • Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands

Confrontation of the unborn child immune system with the noninherited maternal antigens (NIMAs) has a lifelong modulating impact on the immune response of the child against the NIMAs. In this review we summarize the clinical evidence for the existence of the NIMA effect, discuss the possible cellular and molecular basis of the phenomenon, and outline the necessity of further clinical research.

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 Supported in part by the Dutch Kidney Foundation project C00.6011 and Macropa Foundation.

PII: S0037-1963(05)00007-7

doi:10.1053/j.seminhematol.2005.01.008

Seminars in Hematology
Volume 42, Issue 2 , Pages 104-111, April 2005

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