Seminars in Hematology
Volume 41, Issue 3 , Pages 201-206 , July 2004

Perspectives on familial chronic lymphocytic leukemia: genes and the environment

  • Neil Caporaso

      Affiliations

    • Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
    • Corresponding Author InformationAddress correspondence to Neil Caporaso, MD, Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 7116, 6120 Executive Blvd, Rockville, MD 20892 USA
    • ,
  • Gerald E Marti

      Affiliations

    • Flow and Image Cytometry Section, Laboratory of Medical and Molecular Genetics, Division of Cell and Gene Therapies, Federal Drug Administration, Bethesda, MD, USA
    • ,
  • Lynn Goldin

      Affiliations

    • Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA

References 

  1. Sgambati M, Linet MS, Devesa SS. Chronic lymphocytic leukemia epidemiological, familial and genetic aspects. In:  Cheson B editors. Chronic Lymphocytic Leukemias. (ed 2). New York, NY: Marcel Dekker; 2001;p. 33–62
  2. Su’ut LS, O’Connor S, Richards SJ, Jones RA, Roberts B, Davies FE, et al.  Trisomy 12 is seen within a specific subtype of B-cell chronic lymphoproliferative disease affecting the peripheral blood/bone marrow and co-segregates with elevated expression of CD11a. Br J Haematol. 1998;101:165–170
  3. Harris NL, Jaffe ES, Stein H, et al.  A revised European-American classification of lymphomatous neoplasms (A proposal from the International Lymphoma Study Group). Blood. 1994;5:1361–1392
  4. Crespo M, Bosch F, Vilamor N, Bellosilli B, Colomer D, Rozman M, et al.  ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in CLL. N Engl J Med. 2003;348:1764–1775
  5. Groves FD, Linet MS, Devesa SS. Patterns of occurrence of the leukaemias. Eur J Cancer. 1995;31A:941–949
  6. Boggs DR, Chen SC, Zhang ZN, Zhang A. Chronic lymphocytic leukemia in China. Am J Hematol. 1987;25:349–354
  7. Linet MS, Cartwright RA. The leukemias. In:  Schottenfeld D,  Fraumeni JF editor. Cancer Epidemiology and Prevention. New York, NY: Oxford University Press; 1996;p. 841–892
  8. Boice JD, Morin MM, Glass AG, Friedman GD, Stovall M, Hoover RN, et al.  Diagnostic x-ray procedures and risk of leukemia, lymphoma, and multiple myeloma. JAMA. 1991;265:1290–1294
  9. Floderus B, Persson T, Stenlund C, Wennberg A, Ost A, Knave B. Occupational exposure to electromagnetic fields in relation to leukemia and brain tumors (A case-control study in Sweden). Cancer Causes Control. 1993;4:465–476
  10. Kieifets LI, Afifi AA, Buffler PA, Zhang ZW, Matkin CC. Occupational exposure to electromagnetic field exposure and leukemia. A meta-analysis. J Occup Environ Med. 1997;39:1074–1091
  11. Hayes RB, Yin SN, Dosemeci M, Li GL, Wacholder S, Travis AB, et al.  Benzene and the dose-related incidence of hematologic neoplasms in China. Chinese Academy of Preventice Medicine-National Cancer Institute Benzene Study Group. J Natl Cancer Inst. 1997;89:1065–1071
  12. Raabe GK, Wong O. Leukemia mortality by cell type in petroleum workers with potential exposure to benzene. Environ Health Perspect. 1996;104(suppl 6):1381–1392
  13. Lynge E, Anderson A, Nilsson R, Barlow L, Pukkala E, Nordlind R, et al.  Risk of cancer and exposure to gasoline vapors. Am J Epidemiol. 1997;145:449–458
  14. Kogevinas M, Sala M, Boffetta P, Kazerouni N, Kromhout H, Hoar-Zahm S. Cancer risk in the rubber industry (A review of recent epidemiological evidence). Occup Environ Med. 1998;55:1–12
  15. Coggon D, Harris EC, Poole J, Palmer KT. Mortality of workers exposed to ethylene oxide (Extended follow up of a British cohort). Occup Environ Med. 2004;61:358–362
  16. Nanni O, Amadori D, Lugaresi C, Falcini F, Scarpi E, Saragoni A, et al.  CLL and NHL lymphomas by histological type in farming-animal breeding workers (A population case-control study based on a priori exposure matrices). Occup Environ Med. 1996;53:652–657
  17. Hansen ES, Hasle H, Lander F. A cohort study on cancer incidence among Danish gardeners. Am J Ind Med. 1992;21:651–652
  18. Waterhouse D, Carman WJ, Schottenfeld D, Gridley G, McLean S. Cancer incidence in the rural community of Tecumseh, Michigan (A pattern of increased lymphopoietic neoplasms). Cancer. 1996;77:763–770
  19. Blair A, White DW. Leukemia cell types and agricultural practices in Nebraska. Arch Environ Health. 1985;40:211–214
  20. Burmeister LF, Van Lier SF, Isacson P. Leukemia and farm practices in Iowa. Am J Epidemiol. 1982;115:720–728
  21. Bertazzi PA, Consonni D, Bachetti S, Rubagotti M, Baccarelli A, Zocchetti C. Health effects of dioxin exposure (A 20-year mortality study). Am J Epidemiol. 2001;153:1045–1047
  22. Gunz FW, Veale AMO. Leukemia in close relatives—Accident or predisposition?. J Natl Cancer Inst. 1969;42:517–524
  23. Pangalis GA, Angelopoulou MK, Vassilakopoulos TP, Siakantaris MP, Kittas C. B-chronic lymphocytic leukemia, small lymphocytic lymphoma, and lymphoplasmacytic lymphoma, including Waldenstrom’s macroglobulinemia (A clinical, morphologic, and biologic spectrum of similar disorders). Semin Hematol. 1999;36:104–114
  24. Blattner WA, Garber JE, Mann DL, McKeen EA, Henson R, McGuire DB, et al.  Waldenstrom’s macroglobulinemia and autoimmune disease in a family. Ann Intern Med. 1980;93:830–832
  25. Pang JWY, Cook LS, Schwartz SM, Weiss NS. Incidence of leukemia in Asian migrants to the United States and their descendants. Cancer Causes Prev. 2002;13:791–793
  26. Richards CM. Two cases of lymphatic disease in the same family with roentgen findings. Am J Roentgenol. 1921;8:514–515
  27. Videbaek A. Familial leukemia. A preliminary report. Acta Med Scand. 1947;127:26–52
  28. Gunz FW, Gunz JP, Veal AMO, Chapman CJ, Houston IB. Familial leukaemia (A study of 909 families). Scand J Haematol. 1975;15:117–131
  29. Cuttner J. Increased incidence of hematologic malignancies in first-degree relatives of patients with chronic lymphocytic leukemia. Cancer Invest. 1992;10:103–109
  30. Cannon-Albright LA, Thomas A, Goldgar DE, Gholami K, Rowe K, Jacobsen M, et al.  Familiality of cancer in Utah. Cancer Res. 1994;54:2378–2385
  31. Fraumeni JF, Vogel CL, DeVita VT. Familial chronic lymphocytic leukemia. Ann Intern Med. 1969;71:279–284
  32. Ishibe N, Sgambati MT, Fontaine L, Goldin LR, Jain N, Weissman N, et al.  Clinical characteristics of familial B-CLL in the National Cancer Institute Familial Registry. Leuk Lymphoma. 2001;42:99–108
  33. Blattner WA, Strober W, Muchmore AV, Blaese RM, Broder S, Fraumeni JF. Familial chronic lymphocytic leukemia. Immunologic and cellular characterization. Ann Intern Med. 1976;84:554–557
  34. Caporaso NE, Whitehouse J, Bertin P, Amos C, Papadopoulos N, Muller J, et al.  A 20 year clinical and laboratory study of familial B-chronic lymphocytic leukemia in a single kindred. Leuk Lymphoma. 1991;3:331–342
  35. Hemminki K, Li X, Czene K. Familial risk of cancer (Data for clinical counseling and cancer genetics). Int J Cancer. 2004;108:109–114
  36. Goldin LR, Pfeiffer RM, Li X, Henminki K. Familial risk of lymphoproliferative tumors in families of patients with CLL (Results of the Swedish-Family Cancer Database). Blood. 2004; (in press)
  37. Goldin LR, Sgambati M, Marti GE, Fontaine L, Ishibe N, Caporaso NE. Anticipation in familial chronic lymphocytic leukemia. Am J Hum Genet. 1999;65:265–269
  38. Horwitz M, Goode EL, Jarvik GP. Anticipation in familial chronic lymphocytic leukemia. Am J Hum Genet. 1996;59:990–998
  39. Hodge SE. Statistical pitfalls in detecting age-of-onset anticipation. The role of correlation in studying anticipation and detecting ascertainment bias. Psychiatr Genet. 1995;6:61–66
  40. Huang J, Vieland V. A new statistical test for age-of-onset anticipation. Application to bipolar disorder. Genet Epidemiol. 1997;14:1091–1096
  41. Yuille MR, Houlston RS, Catovsky D. Anticipation in familial chronic lymphocytic leukemia. Leukemia. 1998;12:1696–1698
  42. Gale RP, Cozen W, Goodman MT, Wang FF, Bernstein L. Decreased chronic lymphocytic leukemia incidence in Asians in Los Angeles County. Leukemia Res. 2000;24:665–669
  43. Linet M, Bias WB, Dorgan JF, McCaffrey LD, Humphrey RL. HLA antigens in chronic lymphocytic leukemia. Tissue Antigens. 1988;31:71–78
  44. Yuille M, Condie A, Hudson C, Kote-Jarai Z, Stone E, Eeles R. Relationship between glutathione S-transferase M1, T1, and P1 polymorphisms and chronic lymphocytic leukemia. Blood. 2002;99:4216–4218
  45. Saxena A, Moshynska O, Sankaran K, Viswanathan S, Sheridan DP. Association of a novel single nucleotide polymorphism G (−248)A, in the 5’UTR of BAX gene in CLL with disease progression and treatment resistance. Cancer Lett. 2002;187:199–205
  46. Bevan S, Catovsky D, Marossy A, Matutes E, Popat S, Antonovic P, et al.  Linkage analysis for ATM in familial B cell chronic lymphocytic leukaemia. Leukemia. 1999;10:1497–1500
  47. Bevan S, Catovsky D, Matutes E, Antonovic P, Auger MJ, Ben-Bassat I, et al.  Linkage analysis for major histocompatibility complex-related genetic susceptibility in familial chronic lymphocytic leukemia. Blood. 2000;96:3982–3984
  48. Ishibe N, Goldin LR, Caporaso NE, Sgambati MT, Dean M, Albitar M, et al.  ATM mutations and protein expression are not associated with familial B-CLL cases. Leuk Res. 2003;27:973–975
  49. Yuille MR, Condie A, Hudson CD, Bradshaw PS, Stone EM, Matutes E, et al.  ATM mutations are rare in familial chronic lymphocytic leukemia. Blood. 2002;100:603–609
  50. Goldin LR, Ishibe N, Sgambati M, Marti GE, Fontaine L, Lee MP, et al.  A genome scan of 18 families with chronic lymphocytic leukemia. Br J Haematol. 2003;121:866–873
  51. Stilgenbauer S, Dohner H, Lichter P. Genomic aberrations in B-cell CLL. In:  Cheson BD editors. Chronic Lymphocytic Leukemias. (ed 2). Basel, Switzerland: Marcel Dekker; 2001;p. 353–376
  52. Calin GA, Dumitru CD, Shimizu M, Bichi R, Zupo S, Noch E, et al.  Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci USA. 2002;99:15524–15529
  53. Hammarsund M, Corcoran MM, Wilson W, Zhu C, Einhorn S, Sangfelt O, et al.  Characterization of a novel B-CLL candidate gene—DLEU7—located in the 13q14 tumor suppressor locus. FEBS Lett. 2004;556:75–80
  54. Raveche ES, Novotny EA, Hansen CT, Tjio JH, Steinberg AD. Genetic studies in NZB mice. V. Recombinant inbred lines demonstrate that genes control autoimmune phenotype. J Exp Med. 1981;153:1187–1197
  55. Bichi R, Shinton SA, Martin ES, Koval A, Calin GA, Cesari R, et al.  Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression. Proc Natl Acad Sci USA. 2002;14:6955–6960
  56. Hoyer KK, French SW, Turner DE, Nguyen MTN, Renard M, Malone CS. Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma. Proc Natl Acad Sci USA. 2002;99:14392–14397
  57. Marti GE, Mueller J, Stetler-Stevenson M, Caporaso N. B-cell monoclonal lymphocytosis in three individuals living near a hazardous waste-site. In:  Marti GE,  Vogt RF,  Zenger VE editor. Atlanta, GA: Public Health Service, DHHS; 1997;p. 37–50 Proceedings of a USPHS Workshop on Laboratory Approaches to Determining the Role of Environmental Exposures as Risk Factors for B-Cell Lymphoproliferative Disorders
  58. Rawstron AC, Yuille MR, Fuller J, Cullen M, Kennedy B, Richards SJ, et al.  Inherited predisposition to CLL is detectable as subclinical monoclonal B-lymphocyte expansion. Blood. 2002;100:2289–2290
  59. Marti GE, Carter P, Abbasi F, Washington GC, Jain N, Zenger VE, et al.  B-cell monoclonal lymphocytosis and B-cell abnormalities in the setting of familial B-cell lymphocytic leukemia. Cytometry. 2003;52B:1–12
  60. Ghia P, Prate G, Scielzo S, Stella S, Guena M, Guida G, et al.  Monoclonal CD5+ and CD5- B-lymphocyte expansions are frequent in the peripheral blood of the elderly. Blood. 2004;103:2337–2342
  61. Rawstron AC, Green MJ, Kuzmicki A, Kennedy B, Fenton JA, Evans PA, et al.  Monoclonal B lymphocytes with the characteristics of “indolent” chronic lymphocytic leukemia are present in 3.5% of adults with normal blood counts. Blood. 2002;100:635–639
  62. Ligthart GJ, Radl J, Coberand JX, Van Nieuwkoop JA, Van Staalduinen GJ, Van Helmond DJ, et al.  Monoclonal gammopathies in human aging (Increased occurrence with age and correlation with health status). Mech Ageing Dev. 1990;52:235–243

PII: S0037-1963(04)00089-7

doi: 10.1053/j.seminhematol.2004.05.002

Seminars in Hematology
Volume 41, Issue 3 , Pages 201-206 , July 2004

Article Tools