Seminars in Hematology
Volume 40, Issue 2 , Pages 133-142 , April 2003

Diagnosis and epidemiology of human herpesvirus 8 infection

References 

  1. Andreoni M, El-Sawaf G, Rezza G, et al.  High seroprevalence of antibodies to human herpesvirus-8 in Egyptian children: Evidence of nonsexual transmission. J Natl Cancer Inst. 1999;91:465–469
  2. Andreoni M, Goletti D, Pezzotti P, et al.  Prevalence, incidence and correlates of HHV-8/KSHV infection and Kaposi's sarcoma in renal and liver transplant recipients. J Infect. 2001;43:195–199
  3. Angeloni A, Heston L, Uccini S, et al.  High prevalence of antibodies to human herpesvirus 8 in relatives of patients with classic Kaposi's sarcoma from Sardinia. J Infect Dis. 1998;177:1715–1718
  4. Archibald CP, Schechter MT, Craib KJ, et al.  Risk factors for Kaposi's sarcoma in the Vancouver Lymphadenopathy-AIDS Study. J Acquir Immune Defic Syndr. 1990;3(suppl 1):S18–S23
  5. Beral V, Bull D, Darby S, et al.  Risk of Kaposi's sarcoma and sexual practices associated with faecal contact in homosexual or bisexual men with AIDS. Lancet. 1992;339:632–635
  6. Beral V, Peterman TA, Berkelman RL, et al.  Kaposi's sarcoma among persons with AIDS: A sexually transmitted infection?. Lancet. 1990;335:123–128
  7. Bestetti G, Renon G, Mauclere P, et al.  High seroprevalence of human herpesvirus-8 in pregnant women and prostitutes from Cameroon. AIDS. 1998;12:541–543 (letter)
  8. Blackbourn DJ, Ambroziak J, Lennette E, et al.  Infectious human herpesvirus 8 in a healthy North American blood donor. Lancet. 1997;349:609–611
  9. Bourboulia D, Whitby D, Boshoff C, et al.  Serologic evidence for mother-to-child transmission of Kaposi sarcoma-associated herpesvirus infection. JAMA. 1998;280:31–32 (letter)
  10. Cannon MJ, Dollard SC, Smith DK, et al.  Blood-borne and sexual transmission of human herpesvirus 8 in women with or at risk for human immunodeficiency virus infection. HIV Epidemiology Research Study Group. N Engl J Med. 2001;344:637–643
  11. Casper C, Wald A, Pauk J, et al.  Correlates of prevalent and incident Kaposi's sarcoma-associated herpesvirus infection in men who have sex with men. J Infect Dis. 2002;185:990–993
  12. Cesarman E, Chang Y, Moore PS, et al.  Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N Engl J Med. 1995;332:1186–1191
  13. Chandran B, Smith MS, Koelle DM, et al.  Reactivities of human sera with human herpesvirus-8-infected BCBL-1 cells and identification of HHV-8-specific proteins and glycoproteins and the encoding cDNAs. Virology. 1998;243:208–217
  14. Chang Y, Cesarman E, Pessin MS, et al.  Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science. 1994;266:1865–1869
  15. Chatlynne LG, Lapps W, Handy M, et al.  Detection and titration of human herpesvirus-8-specific antibodies in sera from blood donors, acquired immunodeficiency syndrome patients, and Kaposi's sarcoma patients using a whole virus enzyme-linked immunosorbent assay. Blood. 1998;92:53–58
  16. Chokunonga E, Levy LM, Bassett MT, et al.  Cancer incidence in the African population of Harare, Zimbabwe: Second results from the cancer registry 1993-1995. Int J Cancer. 2000;85:54–59
  17. Corchero JL, Mar EC, Spira TJ, et al.  Comparison of serologic assays for detection of antibodies against human herpesvirus 8. Clin Diagn Lab Immunol. 2001;8:913–921
  18. Davidovici B, Karakis I, Bourboulia D, et al.  Seroepidemiology and molecular epidemiology of Kaposi's sarcoma-associated herpesvirus among Jewish population groups in Israel. J Natl Cancer Inst. 2001;93:194–202
  19. Davis DA, Humphrey RW, Newcomb FM, et al.  Detection of serum antibodies to a Kaposi's sarcoma-associated herpesvirus-specific peptide. J Infect Dis. 1997;175:1071–1079
  20. de Sanjose S, Marshall V, Sola J, et al.  Prevalence of Kaposi's sarcoma-associated herpesvirus infection in sex workers and women from the general population in Spain. Int J Cancer. 2002;98:155–158
  21. Diamond C, Huang ML, Kedes DH, et al.  Absence of detectable human herpesvirus 8 in the semen of human immunodeficiency virus-infected men without Kaposi's sarcoma. J Infect Dis. 1997;176:775–777
  22. Diamond C, Thiede H, Perdue T, et al.  Seroepidemiology of human herpesvirus 8 among young men who have sex with men. The Seattle Young Men's Survey Team. Sex Transm Dis. 2001;28:176–183
  23. Diociaiuti A, Nanni G, Cattani P, et al.  HHV8 in renal transplant recipients. Transplant Int. 2000;13(suppl 1):S410–S412
  24. Drew WL, Conant MA, Miner RC, et al.  Cytomegalovirus and Kaposi's sarcoma in young homosexual men. Lancet. 1982;2:125–127
  25. Dukers NH, Renwick N, Prins M, et al.  Risk factors for human herpesvirus 8 seropositivity and seroconversion in a cohort of homosexual men. Am J Epidemiol. 2000;151:213–224
  26. Dukers NHTM, Renwick N, Prins M, et al.  Risk factors for human herpesvirus 8 seropositivity and seroconversion in a cohort of homosexual men. Am J Epidemiol. 2000;151:213–224
  27. Elford J, Tindall B, Sharkey T. Kaposi's sarcoma and insertive rimming. Lancet. 1992;339:938; (letter)
  28. Engels EA, Whitby D, Goebel PB, et al.  Identifying human herpesvirus 8 infection: Performance characteristics of serologic assays. J Acquir Immune Defic Syndr. 2000;23:346–354
  29. Gao SJ, Kingsley L, Hoover DR, et al.  Seroconversion to antibodies against Kaposi's sarcoma-associated herpesvirus-related latent nuclear antigens before the development of Kaposi's sarcoma. N Engl J Med. 1996;335:233–241
  30. Gao SJ, Kingsley L, Li M, et al.  KSHV antibodies among Americans, Italians and Ugandans with and without Kaposi's sarcoma. Nat Med. 1996;2:925–928
  31. Gessain A, Mauclere P, van Beveren M, et al.  Human herpesvirus 8 primary infection occurs during childhood in Cameroon, Central Africa. Int J Cancer. 1999;81:189–192
  32. Greenblatt RM, Jacobson LP, Levine AM, et al.  Human herpesvirus 8 infection and Kaposi's sarcoma among human immunodeficiency virus-infected and -uninfected women. J Infect Dis. 2001;183:1130–1134
  33. Grulich AE, Kaldor JM, Hendry O, et al.  Risk of Kaposi's sarcoma and oroanal sexual contact. Am J Epidemiol. 1997;145:673–679
  34. Grulich AE, Olsen SJ, Luo K, et al.  Kaposi's sarcoma-associated herpesvirus: A sexually transmissible infection?. J Acquir Immune Defic Syndr Hum Retrovirol. 1999;20:387–393
  35. Gutierrez-Ortega P, Hierro-Orozco S, Sanchez-Cisneros R, et al.  Kaposi's sarcoma in a 6-day-old infant with human immunodeficiency virus. Arch Dermatol. 1989;125:432–433
  36. Huang YQ, Li JJ, Rush MG, et al.  HPV-16-related DNA sequences in Kaposi's sarcoma. Lancet. 1992;339:515–518
  37. IARC Working Group . Kaposi's sarcoma herpesvirus/human herpesvirus 8. IARC Monogr Eval Carcinog Risks Hum. 1997;70:375–492
  38. Inoue N, Mar EC, Dollard SC, et al.  New immunofluorescence assays for detection of human herpesvirus 8-specific antibodies. Clin Diagn Lab Immunol. 2000;7:427–435
  39. Jacobson LP, Munoz A, Fox R, et al.  Incidence of Kaposi's sarcoma in a cohort of homosexual men infected with the human immunodeficiency virus type 1. The Multicenter AIDS Cohort Study Group. J Acquir Immune Defic Syndr. 1990;3(suppl 1):S24–S31
  40. Jacobson LP, Springer G, Jenkins FJ, et al.  HHV-8 infection: Incidence and risk factors in the Multicenter AIDS Cohort Study (MACS). In: Third International Workshop on Kaposi Sarcoma-Associated Herpesviruses and Related Agents, Amherst, MA. July 6-10, 2000;
  41. Kedes DH, Ganem D, Ameli N, et al.  The prevalence of serum antibody to human herpesvirus 8 (Kaposi sarcoma-associated herpesvirus) among HIV-seropositive and high-risk HIV-seronegative women. JAMA. 1997;277:478–481
  42. Kedes DH, Lagunoff M, Renne R, et al.  Identification of the gene encoding the major latency-associated nuclear antigen of the Kaposi's sarcoma-associated herpesvirus. J Clin Invest. 1997;100:2606–2610
  43. Kedes DH, Operskalski E, Busch M, et al.  The seroepidemiology of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus): Distribution of infection in KS risk groups and evidence for sexual transmission. Nat Med. 1996;2:918–924
  44. Koelle DM, Huang ML, Chandran B, et al.  Frequent detection of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) DNA in saliva of human immunodeficiency virus-infected men: Clinical and immunologic correlates. J Infect Dis. 1997;176:94–102
  45. Lam LL, Pau CP, Dollard SC, et al.  Highly sensitive assay for human herpesvirus 8 antibodies that uses a multiple antigenic peptide derived from open reading frame K8.1. J Clin Microbiol. 2002;40:325–329
  46. Lifson AR, Darrow WW, Hessol NA, et al.  Kaposi's sarcoma in a cohort of homosexual and bisexual men. Epidemiology and analysis for cofactors Am J Epidemiol. 1990;131:221–231
  47. Luppi M, Barozzi P, Santagostino G, et al.  Molecular evidence of organ-related transmission of Kaposi sarcoma-associated herpesvirus or human herpesvirus-8 in transplant patients. Blood. 2000;96:3279–3281
  48. Mantina H, Kankasa C, Klaskala W, et al.  Vertical transmission of Kaposi's sarcoma-associated herpesvirus. Int J Cancer. 2001;94:749–752
  49. Martin JN, Amad Z, Cossen C, et al.  Use of epidemiologically well-defined subjects and existing immunofluorescence assays to calibrate a new enzyme immunoassay for human herpesvirus 8 antibodies. J Clin Microbiol. 2000;38:696–701
  50. Martin JN, Ganem DE, Osmond DH, et al.  Sexual transmission and the natural history of human herpesvirus 8 infection. N Engl J Med. 1998;338:948–954
  51. Martin JN, Osmond DH. Kaposi's sarcoma-associated herpesvirus and sexual transmission of cancer risk. Curr Opin Oncol. 1999;11:508–515
  52. Martin JN, Osmond DH. Invited commentary: Determining specific sexual practices associated with human herpesvirus 8 transmission. Am J Epidemiol. 2000;151:225–229
  53. Mayama S, Cuevas LE, Sheldon J, et al.  Prevalence and transmission of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in Ugandan children and adolescents. Int J Cancer. 1998;77:817–820
  54. Melbye M, Cook PM, Hjalgrim H, et al.  Risk factors for Kaposi's-sarcoma-associated herpesvirus (KSHV/HHV-8) seropositivity in a cohort of homosexual men, 1981-1996. Int J Cancer. 1998;77:543–548
  55. Miller G, Rigsby MO, Heston L, et al.  Antibodies to butyrate-inducible antigens of Kaposi's sarcoma-associated herpesvirus in patients with HIV-1 infection. N Engl J Med. 1996;334:1292–1297
  56. O'Brien T, Kedes D, Ganem D, et al.  Evidence for concurrent epidemics of human herpesvirus 8 and human immunodeficiency virus type 1 in US homosexual men: Rates, risk factors, and relationship to Kaposi's sarcoma. J Infect Dis. 1999;180:1010–1017
  57. Olsen SJ, Chang Y, Moore PS, et al.  Increasing Kaposi's sarcoma-associated herpesvirus seroprevalence with age in a highly Kaposi's sarcoma endemic region, Zambia in 1985. AIDS. 1998;12:1921–1925
  58. Osmond DH, Buchbinder S, Cheng A, et al.  Prevalence of Kaposi sarcoma-associated herpesvirus infection in homosexual men at beginning of and during the HIV epidemic. JAMA. 2002;287:221–225
  59. Page-Bodkin K, Tappero J, Samuel M, et al.  Kaposi's sarcoma and faecal-oral exposure. Lancet. 1992;339:1490; (letter)
  60. Pau CP, Lam LL, Spira TJ, et al.  Mapping and serodiagnostic application of a dominant epitope within the human herpesvirus 8 ORF 65-encoded protein. J Clin Microbiol. 1998;36:1574–1577
  61. Pauk J, Huang ML, Brodie SJ, et al.  Mucosal shedding of human herpesvirus 8 in men. N Engl J Med. 2000;343:1369–1377
  62. Plancoulaine S, Abel L, van Beveren M, et al.  Human herpesvirus 8 transmission from mother to child and between siblings in an endemic population. Lancet. 2000;356:1062–1065
  63. Quinlivan EB, Wang RX, Stewart PW, et al.  Longitudinal sero-reactivity to human herpesvirus 8 (KSHV) in the Swiss HIV Cohort 4.7 years before KS. Swiss HIV Cohort Study. J Med Virol. 2001;64:157–166
  64. Rabkin CS, Schulz TF, Whitby D, et al.  Interassay correlation of human herpesvirus 8 serologic tests. HHV-8 Interlaboratory Collaborative Group. J Infect Dis. 1998;178:304–309
  65. Rainbow L, Platt GM, Simpson GR, et al.  The 222- to 234-kilodalton latent nuclear protein (LNA) of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) is encoded by orf73 and is a component of the latency-associated nuclear antigen. J Virol. 1997;71:5915–5921
  66. Ransohoff DF, Feinstein AR. Problems of spectrum and bias in evaluating the efficacy of diagnostic tests. N Engl J Med. 1978;299:926–930
  67. Regamey N, Tamm M, Wernli M, et al.  Transmission of human herpesvirus 8 infection from renal-transplant donors to recipients. N Engl J Med. 1998;339:1358–1363
  68. Renwick N, Dukers NH, Weverling GJ, et al.  Risk factors for human herpesvirus 8 infection in a cohort of drug users in the Netherlands, 1985-1996. J Infect Dis. 2002;185:1808–1812
  69. Renwick N, Halaby T, Weverling GJ, et al.  Seroconversion for human herpesvirus 8 during HIV infection is highly predictive of Kaposi's sarcoma. AIDS. 1998;12:2481–2488
  70. Rezza G, Lennette ET, Giuliani M, et al.  Prevalence and determinants of anti-lytic and anti-latent antibodies to human herpesvirus-8 among Italian individuals at risk of sexually and parenterally transmitted infections. Int J Cancer. 1998;77:361–365
  71. Rezza G, Tchangmena OB, Andreoni M, et al.  Prevalence and risk factors for human herpesvirus 8 infection in northern Cameroon. Sex Transm Dis. 2000;27:159–164
  72. Simpson GR, Schulz TF, Whitby D, et al.  Prevalence of Kaposi's sarcoma associated herpesvirus infection by antibodies to recombinant capsid protein and latent antigen. Lancet. 1996;348:1133–1138
  73. Sitas F, Carrara H, Beral V, et al.  Antibodies against human herpesvirus 8 in black South African patients with cancer. N Engl J Med. 1999;340:1863–1871
  74. Smith NA, Sabin CA, Gopal R, et al.  Serologic evidence of human herpesvirus 8 transmission by homosexual but not heterosexual sex. J Infect Dis. 1999;180:600–606
  75. Soulier J, Grollet L, Oksenhendler E, et al.  Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease. Blood. 1995;86:1276–1280
  76. Spira TJ, Lam L, Dollard SC, et al.  Comparison of serologic assays and PCR for diagnosis of human herpesvirus 8 infection. J Clin Microbiol. 2000;38:2174–2180
  77. Tedeschi R, Caggiari L, Silins I, et al.  Seropositivity to human herpesvirus 8 in relation to sexual history and risk of sexually transmitted infections among women. Int J Cancer. 2000;87:232–235
  78. Tedeschi R, De Paoli P, Schulz TF, et al.  Human serum antibodies to a major defined epitope of human herpesvirus 8 small viral capsid antigen. J Infect Dis. 1999;179:1016–1020
  79. US Public Health Service and Infectious Diseases Society of America . Guidelines for preventing opportunistic infections among HIV-infected persons. MMWR Morb Mortal Wkly Rep. 2002;51:1–46
  80. Vitale F, Viviano E, Perna AM, et al.  Serological and virological evidence of non-sexual transmission of human herpesvirus type 8 (HHV8). Epidemiol Infect. 2000;125:671–675
  81. Wang RY, Shih JW, Weiss SH, et al.  Mycoplasma penetrans infection in male homosexuals with AIDS: High seroprevalence and association with Kaposi's sarcoma. Clin Infect Dis. 1993;17:724–729
  82. Wawer MJ, Eng SM, Serwadda D, et al.  Prevalence of Kaposi sarcoma-associated herpesvirus compared with selected sexually transmitted diseases in adolescents and young adults in rural Rakai District, Uganda. Sex Transm Dis. 2001;28:77–81
  83. Whitby D, Howard MR, Tenant-Flowers M, et al.  Detection of Kaposi sarcoma associated herpesvirus in peripheral blood HIV-infected individuals and progression to Kaposi's sarcoma. Lancet. 1995;346:799–802
  84. Whitby D, Luppi M, Barozzi P, et al.  Human herpesvirus 8 seroprevalence in blood donors and lymphoma patients from different regions of Italy. J Natl Cancer Inst. 1998;90:395–397

☆ Supported in part by the National Institutes of Health (U01 CA78124, P30 MH62246, and P30 AI51566) and the University of California Universitywide AIDS Research Program (CC99-SF-001).

☆☆ 0037-1963/03/4002-0004$30.00/0

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Seminars in Hematology
Volume 40, Issue 2 , Pages 133-142 , April 2003

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