Seminars in Hematology
Volume 40, Issue 2 , Pages 124-132 , April 2003

Epstein-Barr virus-associated T-/natural killer cell lymphoproliferative diseases

References 

  1. Aozasa K. Pyothorax-associated lymphoma. Int J Hematol. 1996;65:9–16
  2. Arico M, Imashuku S, Clamenti R, et al.  Hemophagocytic lymphohistiocytosis due to germ line mutations in SHD21A, the X-liked lymphoproliferative disease gene. Blood. 2001;97:1131–1133
  3. Benoit L, Wang X, Pabst HF, et al.  Defective NK cell activation in X-linked lymphoproliferative disease. J Immunol. 2000;165:3549–3553
  4. Borza CM, Hutt-Fletcher LM. Alternative replication in B cells and epithelial cells switches tropism of Epstein-Barr virus. Nat Med. 2002;8:594–599
  5. Catalina MD, Sullivan JL, Brody RM, et al.  Phenotypic and functional heterogeneity of EBV epitope-specific CD8+ T cells. J Immunol. 2002;168:4184–4191
  6. Chan LC, Srivastava G, Pittaluga S, et al.  Detection of Epstein-Barr virus in malignant proliferation of peripheral blood CD3+ CD8+ T cells. Leukemia. 1992;6:952–956
  7. Cohen JI. Epstein-Barr virus infection. N Engl J Med. 2000;343:481–492
  8. Craig MV, Clare N, Skar JL, et al.  T-cell lymphoma and virus-associated hemophagocytic syndrome. Am J Clin Pathol. 1992;97:189–194
  9. Dolezal MV, Kamel OW, vande Rijn M, et al.  Virus-associated hemophagocytic syndrome characterized by clonal Epstein-Barr virus genome. Am J Clin Pathol. 1995;103:189–194
  10. Emile JF, Boulland ML, Haioun C, et al.  CD5− CD56+ T-cell receptor silent peripheral T-cell lymphomas are natural killer cell lymphomas. Blood. 1996;87:1446–1473
  11. Epstein MA, Archong BG, Barr YM. Virus particles in cultured lymphoblasts from Burkitt's lymphoma. Lancet. 1964;1:702–703
  12. Faulner GC, Burrows SR, Khanna R, et al.  X-linked agammaglobulinemia patients are not infected with Epstein-Barr virus: Implications for the biology of the virus. J Virol. 1999;73:1555–1564
  13. Fischer E, Delibraias C, Kazatchkin MD. Expression of CR2 (the C3dg/EBV receptor, CD21) on normal human peripheral blood T lymphocytes. J Immunol. 1991;146:865–872
  14. Gaffey MJ, Frierson HF, Medeiros LJ, et al.  The relationship of Epstein-Barr virus to infection-related (sporadic) and familial hemophagocytic syndrome and secondary (lymphoma-related) hemophagocytosis: An in situ hybridization study. Hum Pathol. 1993;24:657–667
  15. Gallard F, Mechinaud-Lacrois F, Papin S, et al.  Primary Epstein-Barr virus infection with clonal T-cell lymphoproliferation. Am J Clin Pathol. 1992;97:189–194
  16. Haan KM, Kwok WM, Longnecker R, et al.  Epstein-Barr virus entry utilizing HLA-DP or HLA-DQ as a coreceptor. J Virol. 2000;74:2451–2454
  17. Hahn JS, Lee ST, Min YH, et al.  Therapeutic outcome of Epstein-Barr virus positive T/NK cell lymphoma in the upper aerodigestive tract. Yonsei Med J. 2002;43:175–182
  18. Hart DNJ, Baker BW, Inglis MJ, et al.  Epstein-Barr viral DNA in acute large granular lymphocyte (natural killer) leukemia. Blood. 1992;79:2116–2123
  19. Hasegawa D, Kojima S, Tatsumi E, et al.  Elevation of the serum Fas ligand in patients with hemophagocytic syndrome and Diamond-Blackman syndrome. Blood. 1998;91:2793–2799
  20. Hauptmann S, Meru N, Schewe C, et al.  Fatal atypical T-cell proliferation associated with Epstein-Barr virus infection. Br J Haematol. 2001;112:377–380
  21. Henderson S, Huen D, Rowe M, et al.  Epstein-Barr virus-encoded BHRF1 protein, a viral homologue of Bcl-2, protects human B cells from programmed cell death. Proc Natl Acad Sci USA. 1993;90:8479–8483
  22. Hislop AD, Annels NE, Gudgeon NH, et al.  Epitope-specific evolution of human CD8+ T cell responses from primary to persistent phases of Epstein-Barr virus infection. J Exp Med. 2002;195:893–905
  23. Imai S, Sugiura M, Oikawa O, et al.  Epstein-Barr virus (EBV)-carrying and -expressing T-cell lines established from sever chronic active EBV infection. Blood. 1996;87:1446–5147
  24. Imashuku S, Hibi S, Fujiwara F, et al.  Hemophagocytic lymphohistiocytosis, interferon-gammanemia and Epstein-Barr virus involvement. Br J Haematol. 1994;88:656–658
  25. Imashuku S, Hibi S, Todo S. Hemophagocytic lymphohistiocytosis in infancy and childhood. J Pediatr. 1997;130:352–357
  26. Imashuku S, Hibi S, Ohara T, et al.  Effective control of Epstein-Barr virus related hemophagocytic lymphohistiocytosis with immunochemotherapy. Blood. 1999;93:1869–1874
  27. Ishihara S, Tawa A, Yomura-Yagi K, et al.  Clonal T-cell lymphoproliferation containing Epstein-Barr (EB) virus DNA in a patient with chronic active EB virus infection. Jpn J Cancer Res. 1989;80:99–101
  28. Ishihara S, Oshima K, Tokura Y, et al.  Hypersensitivity to mosquito bites conceals clonal lymphoproliferation of Epstein-Barr virus DNA-positive natural killer cells. Jpn J Cancer Res. 1997;88:82–87
  29. Jaffe ES, Chan JKC, Su IJ, et al.  Report of the workshop on nasal and related extranodal angiocentric T/natural killer cell lymphomas. Am J Surg Pathol. 1996;20:103–111
  30. Jones JF, Shurin S, Abramowsky C, et al.  T-cell lymphoma containing Epstein-Barr viral DNA in patients with chronic Epstein-Barr virus infection. N Engl J Med. 1988;318:733–736
  31. Kanavaros P, Lescs M-C, Briere J, et al.  Nasal T lymphoma: A clinicopathologic entity associated with peculiar phenotype and Epstein-Barr virus. Blood. 1993;81:2688–2695
  32. Kanegane H, Wada T, Nunogami K, et al.  Chronic persistent Epstein-Barr virus infection of natural killer cells and B cells associated with granular lymphocytes expansion. Br J Haematol. 1996;95:116–122
  33. Kanegane H, Bhata K, Gutierrez N, et al.  A syndrome of peripheral blood T cell infection with Epstein-Barr virus (EBV) followed by EBV-positive T-cell lymphoma. Blood. 1998;91:2085–2091
  34. Kanegane H, Wakiguchi H, Kanegane C, et al.  Increased cell-free viral DNA in fatal cases of chronic active Epstein-Barr virus infection. Clin Infect Dis. 1999;28:906–909
  35. Kasahara Y, Yachie A, Takei K, et al.  Differential cellular targets of Epstein-Barr virus (EBV) infection between acute EBV-associated hemophagocytic lymphohistiocytosis and chronic active EBV infection. Blood. 2001;98:1882–1888
  36. Kawa-Ha K, Ishihara S, Ninomiya T, et al.  CD3-negative lymphoproliferative disease of granular lymphocytes containing Epstein-Barr viral DNA. J Clin Invest. 1989;84:51–55
  37. Kawa K, Okamura T, Yagi K, et al.  Mosquito allergy and Epstein-Barr-virus-associated T/natural killer-cell lymphoproliferative disease. Blood. 2001;98:3173–3174
  38. Kawaguchi H, Miyashita T, Herbst H, et al.  Epstein-Barr virus-infected T lymphocytes in Epstein-Barr virus-associated hemophagocytic syndrome. J Clin Invest. 1993;92:1444–1450
  39. Kikuta H, Taguchi Y, Tomizawa K, et al.  Epstein-Barr virus-genome-positive T lymphocytes in a boy with chronic active EBV infection associated with Kawasaki-like disease. Nature. 1988;333:455–457
  40. Kikuta H, Sakiyama Y, Matsumoto S, et al.  Fatal Epstein-Barr virus-associated hemophagocytic syndrome. Blood. 1993;82:3259–3264
  41. Kimura H, Morita M, Yatabe Y, et al.  Quantitative analysis of Epstein-Barr virus load by using real-time PCR assay. J Clin Microbiol. 1999;37:132–136
  42. Kimura H, Hoshino Y, Kanegane H, et al.  Clinical and virologic characteristic of chronic active Epstein-Barr virus infection. Blood. 2001;98:230–236
  43. Koehne G, Smith KM, Ferguson TL, et al.  Quantitation, selection, and functional characterization of Epstein-Barr virus-specific and alloreactive T cells detected by intracellular interferon-g production and growth of cytotoxic precursors. Blood. 2002;99:1730–1740
  44. Lay JG, Tsao CJ, Chen JY, et al.  Upregulation of tumor necrosis factor-α gene by Epstein-Barr virus and activation of macrophages in Epstein-Barr virus-infected T cells in the pathogenesis of hemophagocytic syndrome. J Clin Invest. 1997;100:1969–1979
  45. Li Q, Spriggs MK, Kovats S, et al.  Epstein-Barr virus uses HLA class II as a cofactor for infection for B lymphocytes. J Virol. 1997;71:4657–4662
  46. Loughran TP, Zambello R, Ashley R, et al.  Failure to detect Epstein-Barr virus DNA in peripheral blood mononuclear cells of most patients with large granular lymphocyte leukemia. Blood. 1993;81:2723–2727
  47. Mori M, Kurozumi H, Akagi K, et al.  Monoclonal proliferation of T cells containing Epstein-Barr virus in fatal mononucleosis. N Engl J Med. 1992;327:58
  48. Mroczek EC, Weisenburger DD, Grierson H, et al.  Fatal infectious mononucleosis and virus-associated hemophagocytic syndrome. Arch Pathol Lab Med. 1987;111:530–535
  49. Nagata S. Apoptosis by death factor. Cell. 1997;88:355–359
  50. Noma T, Kou K, Yoshizawa I, et al.  Monoclonal proliferation of Epstein-Barr virus-infected T-cells in a patient with virus-associated hemophagocytic syndrome. Eur J Pediatr. 1994;153:734–738
  51. Ohshima K, Suzumiya J, Sugihara M, et al.  Clinicopathological study of severe chronic active Epstein-Barr virus infection that developed in association with lymphoproliferative disorder and/or hemophagocytic syndrome. Pathol Int. 1998;48:934–943
  52. Okamura T, Hatsukawa Y, Arai H, et al.  Blood stem transplantation for chronic active Epstein-Barr virus with lymphoproliferation. Lancet. 2000;356:223–224
  53. Okano M, Matsumoto S, Osato T, et al.  Severe chronic active Epstein-Barr virus infection syndrome. Clin Microbiol Rev. 1991;4:129–135
  54. Quinatallia-Martinaz L, Kumar S, Fend F, et al.  Fulminant EBV+ T-cell lymphoproliferative disorder following acute/chronic EBV infection: Distinct clinicopathologic syndrome. Blood. 2000;96:443–451
  55. Rickinson AB. Chronic, symptomatic Epstein-Barr virus infection. Immunol Today. 1986;7:12–14
  56. Rickinson AB, Kieff E. Epstein-Barr virus. In: ed 3.  Fields BN,  Knipe DM,  Howley PM, et al. editor. Fields Virology. Philadelphia, PA: Lippincott-Raven; 1996;p. 2397–2446
  57. Schooley RT, Carey RW, Miller G, et al.  Chronic Epstein-Barr virus infection associated with fever and interstitial pneumonitis. Clinical and serrological features and response to antiviral chemotherapy. Ann Intern Med. 1986;104:636–643
  58. Scott AA, Head DR, Kopecky KJ, et al.  HLA-DR−, CD33+, CD56+, CD16− myeloid/natural killer cell acute leukemia: a previous unrecognized form of acute leukemia potentially misdiagnosed as French-American-British acute myeloid leukemia-M3. Blood. 1994;84:244–255
  59. Semenzato G, Zambello R, Starkebaum G, et al.  The lymphoproliferative disease of granular lymphocytes: Updated criteria for diagnosis. Blood. 1997;89:256–260
  60. Shimodaira S, Ishida F, Kobayashi H. The detection of clonal proliferation in granular lymphocyte-proliferative disorders of natural killer cell lineage. Br J Haematol. 1999;90:578–584
  61. Soto NE, Straus SE. Chronic fatigue syndrome and herpesviruses: The fading evidence. Herpes. 2000;7:46–50
  62. Stepp SE, Dufourcq-Legelouse R, Deist FL, et al.  Perforin gene defects in familial hemophagocytic lymphohistiocytosis. Science. 1999;286:1957–1959
  63. Straus SE. The chronic mononucleosis syndrome. J Infect Dis. 1988;157:405–412
  64. Straus SE, Cohen JI, Tosato G, et al.  Epstein-Barr virus infections: Biology, pathogenesis, and management. Ann Intern Med. 1993;118:45–58
  65. Su I-J, Lin K-H, Chen C-J, et al.  Epstein-Barr virus-associated peripheral T-cell lymphoma of activated CD8 phenotype. Cancer. 1990;66:2557–2562
  66. Su IJ, Wang CH, Cheng AL, et al.  Hemophagocytic syndrome in Epstein-Barr virus-associated T-lymphoproliferative disorders: Disease spectrum, pathogenesis, and management. Leuk Lymphoma. 1995;19:401–406
  67. Sugiyama M, Ito M, Ichimi R, et al.  A case of Epstein-Barr infection with exophthalmos and ocular muscle swelling. Acta Pediatr Jpn. 1997;39:694–697
  68. Sumazaki R, Kanegane H, Osaki M, et al.  SH2D1A mutations in Japanese males with severe Epstein-Barr virus-associated illnesses. Blood. 2001;98:1266–1270
  69. Taketani K, Kikuchi A, Inatomi J, et al.  Chronic active Epstein-Barr virus infection (CAEBV) successfully treated with allogeneic peripheral blood stem cell transplantation. Bone Marrow Transplant. 2002;29:531–533
  70. Tamaru Y, Miyawaki T, Iwai K, et al.  Absence of Bcl-2 expression by activated CD45RO+ T lymphocytes in acute infectious mononucleosis supporting susceptibility to programmed cell death. Blood. 1993;82:521–527
  71. Tanaka Y, Sasaki Y, Koizumi H, et al.  Angiocentric immunoproliferative lesion associated with chronic active Epstein-Barr virus infection in an 11-year-old boy. Clonotropic proliferation of Epstein-Barr virus-bearing CD4+ T lymphocytes. Am J Surg Pathol. 1994;18:623–631
  72. Tangye S, Phillips JH, Lanier LL, et al.  Functional requirement for SAP in 2B4-mediated activation of human natural killer cells as revealed by the X-linked lymphoproliferative syndrome. J Immunol. 2000;165:2932–2936
  73. Tazawa Y, Nishinomiya F, Noguchi H, et al.  A case of fatal infectious mononucleosis presenting with fulminant hepatic failure associated with an extensive CD8-positive lymphocyte infiltration in the liver. Hum Pathol. 1993;24:1135–1139
  74. Tomita Y, Ohsawa M, Qui K, et al.  Epstein-Barr virus in lymphoproliferative disease in the sino-nasal region: Close-association with CD56+ immunophenotype and polymorphic-reticulosis morphology. Int J Cancer. 1997;70:9–13
  75. Tosato G, Taga K, Angiolillo AL, et al.  Epstein-Barr virus as an agent of haematological disease. Baillieres Clin Haematol. 1995;8:165–199
  76. Trapani JA, Sutton VR, Smyth MJ. CTL granules: Evolution of vesicles essential for combating virus infection. Immunol Today. 1999;20:351–356
  77. Tsuchiyama J, Yoshino T, Mori M, et al.  Characterization of a novel human natural killer-cell line (NK-YS) established from natural killer cell lymphoma/leukemia associated with Epstein-Barr virus infection. Blood. 1998;92:1374–1383
  78. Tuge T, Morishima H, Morita M, et al.  Characterization of Epstein-Barr virus (EBV)-carrying natural killer (NK) cell proliferation with severe mosquito allergy: Establishment of an IL-2-dependent NK-like cell line. Clin Exp Immunol. 1999;115:365–392
  79. Uehara T, Miyawaki T, Ohta K, et al.  Apoptotic cell death in primed CD45RO+ T lymphocytes in Epstein-Barr virus-induced infectious mononucleosis. Blood. 1992;60:453–460
  80. Weiss LM, Movahed LA, Warnke RA, et al.  Detection of Epstein-Barr virus genome in Reed-Sternberg cells in Hodgkin's disease. N Engl J Med. 1989;320:502–506

☆ Supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan, and by a grant from the Ministry of Health, Labour and Welfare of Japan.

☆☆ 0037-1963/03/4002-0003$30.00/0

PII: S0037-1963(03)70004-3

Seminars in Hematology
Volume 40, Issue 2 , Pages 124-132 , April 2003

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