Seminars in Hematology
Volume 41, Issue 1 , Pages 60-67 , January 2004

The Oklahoma thrombotic thrombocytopenic Purpura-Hemolytic uremic syndrome (TTP-HUS) registry: a community perspective of patients with clinically diagnosed TTP-HUS

  • James N George

      Affiliations

    • Corresponding Author InformationAddress correspondence to James N. George, M.D., The University of Oklahoma Health Sciences Center, Hematology-Oncology Section, PO Box 26901, Oklahoma City, OK 73190, USA
    • Hematology-Oncology Section, Department of Medicine, College of Medicine, and the Department of Biostatistics and Epidemiology, College of Public Health, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    • ,
  • Sara K Vesely

      Affiliations

    • Hematology-Oncology Section, Department of Medicine, College of Medicine, and the Department of Biostatistics and Epidemiology, College of Public Health, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    • ,
  • Deirdra R Terrell

      Affiliations

    • Hematology-Oncology Section, Department of Medicine, College of Medicine, and the Department of Biostatistics and Epidemiology, College of Public Health, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA

References 

  1. Rock GA, Shumak KH, Buskard NA, Blanchette VS, Kelton JG, Nair RC, et al.  Comparison of plasma exchange with plasma infusion in the treatment of thrombotic thrombocytopenic purpura. N Engl J Med. 1991;325:393–397
  2. Rock G, Shumak K, Kelton J, Blanchette VS, Buskard N, Nair R, et al.  Thrombotic thrombocytopenic purpura (Outcome in 24 patients with renal impairment treated with plasma exchange). Transfusion. 1992;32:710–714
  3. Thompson CE, Damon LE, Ries CA, Linker CA. Thrombotic microangiopathies in the 1980s (Clinical features, response to treatment, and the impact of the human immunodeficiency virus epidemic). Blood. 1992;80:1890–1895
  4. George JN. How I treat patients with thrombotic thrombocytopenic purpura-hemolytic uremic syndrome. Blood. 2000;96:1223–1229
  5. Gerber A, Karch H, Allerberger F, Verweyen HM, Zimmerhackl LB. Clinical course and the role of Shiga toxin-producing Escherichia coli infection in the hemolytic-uremic syndrome in pediatric patients, 1997–2000, in Germany and Austria (A prospective study). J Infect Dis. 2002;186:493–500
  6. Rizvi MA, Vesely SK, George JN, Chandler L, Duvall D, Smith JW, et al.  Complications of plasma exchange in 71 consecutive patients treated for clinically suspected thrombotic thrombocytopenic purpura-hemolytic uremic syndrome. Transfusion. 2000;40:896–901
  7. McMinn JR, Thomas IA, Terrell DR, Duvall D, Vesely SK, George JN. Complications of plasma exchange in patients treated for clinically suspected thrombotic thrombocytopenic purpura-hemolytic uremic syndrome An additional study of 78 consecutive patients. Transfusion. 2003;43:415–416
  8. Vesely SK, George JN, Lammle B, Studt JD, Alberio L, El-Harake MA, et al.  ADAMTS13 activity in thrombotic thrombocytopenic purpura-hemolytic uremic syndrome (Relation to presenting features and clinical outcomes in a prospective cohort of 142 patients). Blood. 2003;101:60–68
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  10. Howard MA, Duvall D, Terrell DR, Christopher A, Thomas I, Holloway NM, et al.  A support group for patients who have recovered from thrombotic thrombocytopenic purpura-hemolytic uremic syndrome (The six year experience of the Oklahoma TTP-HUS Study Group). J Clin Apheresis. 2003;18:16–20
  11. Clark WF, Rock GA, Buskard N, Shumak KH, Leblond P, Anderson D, et al.  Therapeutic plasma exchange (An update from the Canadian Apheresis Group). Ann Intern Med. 1999;131:453–462
  12. Roy V, Rizvi MA, Vesely SK, George JN. Thrombotic thrombocytopenic purpura-like syndromes following bone marrow transplantation (An analysis of associated conditions and clinical outcomes). Bone Marrow Transplantation. 2001;27:641–646
  13. Robboy SJ, Salisbury K, Ragsdale B, Bobroff LM, Jacobson BM, Colman RW. Mechanism of Aspergillus-induced microangiopathic hemolytic anemia. Arch Intern Med. 1971;128:790–793
  14. Grigg A, Clouston D. Disseminated fungal infection and early onset microangiopathy after allogeneic bone marrow transplantation. Bone Marrow Transplant. 1995;15:795–797
  15. Pihusch R, Salat C, Schmidt E, Gohring P, Pihusch M, Hiller E, et al.  Hemostatic complications in bone marrow transplantation (A retrospective analysis of 447 patients). Bone Marrow Transplant. 2002;74:1303–1309
  16. McMinn JR, George JN. Evaluation of women with clinically suspected thrombotic thrombocytopenic purpura-hemolytic uremic syndrome during pregnancy. J Clin Apheresis. 2001;16:202–209
  17. George JN. The association of pregnancy with thrombotic thrombocytopenic purpura-hemolytic uremic syndrome. Curr Opin Hematol (in press)
  18. Witlin AG, Mattar F, Sibai BM. Postpartum stroke (A twenty-year experience). Am J Obstet Gynecol. 2000;183:83–88
  19. Mannucci PM, Canciani MT, Forza I, Lussana F, Lattuada A, Rossi E. Changes in health and disease of the metalloprotease that cleaves von Willebrand factor. Blood. 2001;98:2730–2735
  20. Reiter RA, Knobl P, Varadi K, Turecek PL. Changes in von Willebrand factor-cleaving protease (ADAMTS13) activity after infusion of desmopressin. Blood. 2003;101:946–948
  21. Kojouri K, Vesely S, George JN. Quinine-associated thrombotic thrombocytopenic purpura-hemolytic uremic syndrome (Frequency, clinical features, and long-term outcomes). Ann Intern Med. 2001;135:1047–1051
  22. Leach JW, Pham T, Diamandidis D, George JN. Thrombotic thrombocytopenic purpura-hemolytic uremic syndrome (TTP-HUS) following treatment with deoxycoformycin in a patient with cutaneous T cell lymphoma (Sezary syndrome) (A case report). Am J Hematol. 1999;61:268–270
  23. Kovacs MJ, Roddy J, Grégoire S, Cameron W, Eidus L, Drouin J. Thrombotic thrombocytopenic purpura following hemorrhagic colitis due to Escherichia coli 0157:H7. Am J Med. 1990;88:177–179
  24. Dundas S, Murphy J, Soutar RL, et al.  Effectiveness of therapeutic plasma exchange in the 1996 Lanarkshire Escherichia coli 0157:H7 outbreak. Lancet. 1999;354:1327
  25. Hassell KL, Eckman JR, Lane PA. Acute multiorgan failure syndrome (A potentially catastrophic complication of severe sickle cell pain episodes). Am J Med. 1994;96:155–162
  26. Daryanani S, Wilde JT. Relapsing thrombotic thrombocytopenic purpura in association with recurrent pancreatitis. Clin Lab Haematol. 1998;20:317–318
  27. Vergara M, Modolell I, Puig-Divi V, Guarner L, Malagelada JR. Acute pancreatitis as a triggering factor for thrombotic thrombocytopenic purpura. Am J Gastrol. 1998;93:2215–2218
  28. Mannucci PM. Thrombotic thrombocytopenic purpura (A simpler diagnosis at last?). Thromb Haemost. 1999;82:1380–1381
  29. Cines DB, Konkle BA, Furlan M. Thrombotic thrombocytopenic purpura (A paradigm shift?). Thromb Haemost. 2000;84:528–535
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  31. George JN, Vesely SK. Thrombotic thrombocytopenic purpura (From the bench to the bedside, but not yet to the community). (editorial) Ann Intern Med. 2003;138:152–153

PII: S0037-1963(03)00266-X

doi: 10.1053/j.seminhematol.2003.10.001

Seminars in Hematology
Volume 41, Issue 1 , Pages 60-67 , January 2004

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