Seminars in Hematology
Volume 40, Issue 4 , Pages 268-273, October 2003

MLL-rearranged leukemias: insights from gene expression profiling

  • Scott A Armstrong

      Affiliations

    • Departments of Pediatric Oncology, Cancer, Immunology and AIDS, and Howard Hughes Medical Institute, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    • The Whitehead Institute Genome Center, Cambridge, MA, USA
    • ,
  • Todd R Golub

      Affiliations

    • Departments of Pediatric Oncology, Cancer, Immunology and AIDS, and Howard Hughes Medical Institute, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    • ,
  • Stanley J Korsmeyer

      Affiliations

    • Departments of Pediatric Oncology, Cancer, Immunology and AIDS, and Howard Hughes Medical Institute, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    • Corresponding Author InformationAddress correspondence to Stanley J. Korsmeyer, MD, Dana-Farber Cancer Institute, One Jimmy Find Way, Boston, MA 02115, USA

Abstract 

Gene expression analysis of human leukemias has provided insight into disease classification and mechanisms of oncogenesis. Its success is particularly evident for acute leukemias with rearrangement of the mixed lineage leukemia (MLL) gene on chromosome 11q23. Unlike most other recurrent translocations, MLL rearrangements are found in leukemias classified as acute myelogenous leukemia (AML) or acute lymphoblastic leukemia (ALL). In addition, MLL-rearranged leukemias often express both myeloid- and lymphoid-associated genes. These unusual characteristics have generated much interest in the cell of origin and the mechanism of transformation by MLL rearrangements. Here we review insights gained from characterization of MLL-rearranged human leukemias by genome-wide expression profiling and compare these to data from model systems.

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PII: S0037-1963(03)00196-3

doi:10.1016/S0037-1963(03)00196-3

Seminars in Hematology
Volume 40, Issue 4 , Pages 268-273, October 2003

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