Seminars in Hematology
Volume 40, Issue 3 , Pages 257-266 , July 2003

Plasmacytoid dendritic cells: From the plasmacytoid T-cell to type 2 dendritic cells CD4+CD56+ malignancies

  • Marie C. Béné

      Affiliations

    • *Address correspondence to Marie C. Béné, PhD, Laboratoire d’Immunologie du CHU, Faculté de Médecine, BP 184, 9 Avenue de la Forêt de Haye, 54500, Vandoeuvre les Nancy, France
    • Laboratoire d’Immunologie du CHU, Faculté de Médecine, Nancy, France
    • ,
  • Jean Feuillard

      Affiliations

    • Laboratoire d’Hématologie, CHU Dupuytren, Limoges, France
    • ,
  • Marie C. Jacob

      Affiliations

    • Department of Research and Development, Groupe de Recherche sur les Lymphomes, EFS Rhône-Alpes Grenoble, La Tronche, France
    • ,
  • the Groupe d’Etude Immunologique des Leucémies

References 

  1. Adachi M, Maeda K, Takekawa M, et al.  High expression of CD56 (N-CAM) in a patient with cutaneous CD4-positive lymphoma. Am J Hematol. 1994;47:278–282
  2. Amo Y, Ogata F, Okabe S, et al.  CD56-positive cutaneous lymphoma with multicentric Castleman’s disease-like systemic manifestations. J Dermatol. 2001;28:746–752
  3. Baddoura FK, Hanson C, Chan WC. Plasmacytoid monocyte proliferation associated with myeloproliferative disorders. Cancer. 1992;69:1457–1467
  4. Bagot M, Bouloc A, Charue D, et al.  Do primary cutaneous non-T non-B CD4+CD56+ lymphomas belong to the myelo-monocytic lineage?. J Invest Dermatol. 1998;111:1242–1244
  5. Banchereau J, Pulendran B, Steinman R, et al.  Will the making of plasmacytoid dendritic cells in vitro help unravel their mysteries?. J Exp Med. 2000;192:F39–F44
  6. Bayerl MG, Rakozy CK, Mohamed AN, et al.  Blastic natural killer cell lymphoma/leukemia: A report of seven cases. Am J Clin Pathol. 2002;117:41–50
  7. Bendriss-Vermare N, Barthelemy C, Durand I, et al.  Human thymus contains IFN-alpha-producing CD11c(-), myeloid CD11c(+), and mature interdigitating dendritic cells. J Clin Invest. 2001;107:835–844
  8. Blom B, Ho S, Antonenko S, Liu YJ. Generation of interferon alpha-producing predendritic cell (Pre-DC)2 from human CD34(+) hematopoietic stem cells. J Exp Med. 2000;192:1785–1796
  9. Briere F, Bendriss-Vermare N, Delale T, et al.  Origin and filiation of human plasmacytoid dendritic cells. Hum Immunol. 2002;63:1081–1093
  10. Brody JP, Allen S, Schulman P, et al.  Acute agranular CD4-positive natural killer cell leukemia. Comprehensive clinicopathologic studies including virologic and in vitro culture with inducing agents. Cancer. 1995;75:2474–2483
  11. Caldwell CW, Yesus YW, Loy TS, et al.  Acute leukemia/lymphoma of plasmacytoid T-cell type. Am J Clin Pathol. 1990;94:778–786
  12. Cella M, Jarrossay D, Facchetti F, et al.  Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon. Nat Med. 1999;5:919–923
  13. Chang SE, Choi HJ, Huh J, et al.  A case of primary cutaneous CD56+, TdT+, CD4+, blastic NK-cell lymphoma in a 19-year-old woman. Am J Dermatopathol. 2002;24:72–75
  14. Chaperot L, Bendriss N, Manches O, et al.  Identification of a leukemic counterpart of the plasmacytoid dendritic cells. Blood. 2001;97:3210–3217
  15. De Vos R, De Wolf-Peeters C, Facchetti F, et al.  Plasmacytoid monocytes in epithelioid cell granulomas: Ultrastructural and immunoelectron microscopic study. Ultrastruct Pathol. 1990;14:291–302
  16. DeLisser HM, Newman PJ, Albelda SM. Molecular and functional aspects of PECAM-1/CD31. Immunol Today. 1994;15:490–495
  17. DiGiuseppe JA, Louie DC, Williams JE, et al.  Blastic natural killer cell leukemia/lymphoma: A clinicopathologic study. Am J Surg Pathol. 1997;21:1223–1230
  18. Drenou B, Lamy T, Amiot L, et al.  CD3− CD56+ non-Hodgkin’s lymphomas with an aggressive behavior related to multidrug resistance. Blood. 1997;89:2966–2974
  19. Dummer R, Potoczna N, Haffner AC, et al.  A primary cutaneous non-T, non-B CD4+, CD56+ lymphoma. Arch Dermatol. 1996;132:550–553
  20. Dzionek A, Fuchs A, Schmidt P, et al.  BDCA-2, BDCA-3, and BDCA-4: Three markers for distinct subsets of dendritic cells in human peripheral blood. J Immunol. 2000;165:6037–6046
  21. Dzionek A, Inagaki Y, Okawa K, et al.  Plasmacytoid dendritic cells: From specific surface markers to specific cellular functions(1). Hum Immunol. 2002;63:1133–1148
  22. Facchetti F, Boden G, De Wolf-Peeters C, et al.  Plasmacytoid monocytes in Jessner’s lymphocytic infiltration of the skin. Am J Dermatopathol. 1990;12:363–369
  23. Facchetti F, De Wolf-Peeters C, Kennes C, et al.  Leukemia-associated lymph node infiltrates of plasmacytoid monocytes (so-called plasmacytoid T-cells). Evidence for two distinct histological and immunophenotypical patterns. Am J Surg Pathol. 1990;14:101–112
  24. Facchetti F, de Wolf-Peeters C, Mason DY, et al.  Plasmacytoid T cells. Immunohistochemical evidence for their monocyte/macrophage origin. Am J Pathol. 1988;133:15–21
  25. Facchetti F, De Wolf-Peeters C, van den Oord JJ, et al.  Plasmacytoid T cells: A cell population normally present in the reactive lymph node. An immunohistochemical and electronmicroscopic study. Hum Pathol. 1988;19:1085–1092
  26. Facchetti F, De Wolf-Peeters C, Van den Oord JJ, et al.  Plasmacytoid T cells in a case of lymphocytic infiltration of skin. A component of the skin-associated lymphoid tissue?. J Pathol. 1988;155:295–300
  27. Falcao RP, Garcia AB, Marques MG, et al.  Blastic CD4 NK cell leukemia/lymphoma: A distinct clinical entity. Leuk Res. 2002;26:803–807
  28. Feuillard J, Jacob MC, Valensi F, et al.  Clinical and biologic features of CD4(+)CD56(+) malignancies. Blood. 2002;99:1556–1563
  29. Galibert L, Maliszewski CR, Vandenabeele S. Plasmacytoid monocytes/T cells: A dendritic cell lineage?. Semin Immunol. 2001;13:283–289
  30. Ginarte M, Abalde MT, Peteiro C, et al.  Blastoid NK cell leukemia/lymphoma with cutaneous involvement. Dermatology. 2000;201:268–271
  31. Greenwalt DE, Lipsky RH, Ockenhouse CF, et al.  Membrane glycoprotein CD36: A review of its roles in adherence, signal transduction, and transfusion medicine. Blood. 1992;80:1105–1115
  32. Grouard G, Rissoan MC, Filgueira L, et al.  The enigmatic plasmacytoid T cells develop into dendritic cells with interleukin (IL)-3 and CD40-ligand. J Exp Med. 1997;185:1101–1111
  33. Harris NL, Demirjian Z. Plasmacytoid T-zone cell proliferation in a patient with chronic myelomonocytic leukemia. Histologic and immunohistologic characterization. Am J Surg Pathol. 1991;15:87–95
  34. Hayashi K, Nakamura S, Koshikawa T, et al.  A case of neural cell adhesion molecule-positive peripheral T-cell lymphoma associated with human T-cell lymphotrophic virus type 1 showing an unusual involvement of the gastrointestinal tract during the course of the disease. Hum Pathol. 1994;25:1251–1253
  35. Hofbauer GF, Kamarachev J, Kempf W, et al.  A CD4+ CD56+ natural killer-like T-cell systemic lymphoma with haemorrhagic cutaneous manifestations. Br J Dermatol. 2001;144:432–434
  36. Honda S, Ito Y, Otawa M, et al.  CD56- and CD4-positive non-Hodgkin’s lymphoma of probable T-cell origin. Rinsho Ketsueki. 2001;42:420–425
  37. Ito T, Amakawa R, Kaisho T, et al.  Interferon-alpha and interleukin-12 are induced differentially by Toll-like receptor 7 ligands in human blood dendritic cell subsets. J Exp Med. 2002;195:1507–1512
  38. Jaffe ES, Chan JK, Su IJ, et al.  Report of the Workshop on Nasal and Related Extranodal Angiocentric T/Natural Killer Cell Lymphomas. Definitions, differential diagnosis, and epidemiology. Am J Surg Pathol. 1996;20:103–111
  39. Jahnsen FL, Lund-Johansen F, Dunne JF, et al.  Experimentally induced recruitment of plasmacytoid (CD123high) dendritic cells in human nasal allergy. J Immunol. 2000;165:4062–4068
  40. Jarrossay D, Napolitani G, Colonna M, et al.  Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells. Eur J Immunol. 2001;31:3388–3393
  41. Kameoka J, Ichinohasama R, Tanaka M, et al.  A cutaneous agranular CD2- CD4+ CD56+ “lymphoma”: Report of two cases and review of the literature. Am J Clin Pathol. 1998;110:478–488
  42. Kato N, Yasukawa K, Kimura K, et al.  CD2- CD4+ CD56+ hematodermic/hematolymphoid malignancy. J Am Acad Dermatol. 2001;44:231–238
  43. Khoury JD, Medeiros LJ, Manning JT, et al.  CD56(+) TdT(+) blastic natural killer cell tumor of the skin: A primitive systemic malignancy related to myelomonocytic leukemia. Cancer. 2002;94:2401–2408
  44. Kimura S, Kakazu N, Kuroda J, et al.  Agranular CD4+CD56+ blastic natural killer leukemia/lymphoma. Ann Hematol. 2001;80:228–231
  45. Knudsen H, Gronbaek K, thor Straten P, et al.  A case of lymphoblastoid natural killer (NK)-cell lymphoma. Association with the NK-cell receptor complex CD94/NKG2 and TP53 intragenic deletion. Br J Dermatol. 2002;146:148–153
  46. Ko YH, Kim SH, Park K, et al.  CD4+CD56+CD68+ hematopoietic tumor of probable plasmacytoid monocyte derivation with weak expression of cytoplasmic CD3. J Korean Med Sci. 2002;17:833–839
  47. Koo CH, Mason DY, Miller R, et al.  Additional evidence that “plasmacytoid T-cell lymphoma” associated with chronic myeloproliferative disorders is of macrophage/monocyte origin. Am J Clin Pathol. 1990;93:822–827
  48. Lennert K, Remmele W. Karyometrische untershungen an lymphoknotenzellen des Menschen I. Germinoblasten, lymphoblasten und lymphozyten. Acta Haematol (Basel). 1958;19:99–113
  49. Leroux D, Mugneret F, Callanan M, et al.  CD4(+), CD56(+) DC2 acute leukemia is characterized by recurrent clonal chromosomal changes affecting 6 major targets: A study of 21 cases by the Groupe Francais de Cytogenetique Hematologique. Blood. 2002;99:4154–4159
  50. Liu YJ, Kanzler H, Soumelis V, et al.  Dendritic cell lineage, plasticity and cross-regulation. Nat Immunol. 2001;2:585–588
  51. Mongkonsritragoon W, Letendre L, Qian J, et al.  Nodular lesions of monocytic component in myelodysplastic syndrome. Am J Clin Pathol. 1998;110:154–162
  52. Muller-Hermelink HK, Stein H, Steinmann G, et al.  Malignant lymphoma of plasmacytoid T-cells. Morphologic and immunologic studies characterizing a special type of T-cell. Am J Surg Pathol. 1983;7:849–862
  53. Nagatani T, Okazawa H, Kambara T, et al.  Cutaneous monomorphous CD4- and CD56-positive large-cell lymphoma. Dermatology. 2000;200:202–208
  54. Olweus J, BitMansour A, Warnke R, et al.  Dendritic cell ontogeny: A human dendritic cell lineage of myeloid origin. Proc Natl Acad Sci USA. 1997;94:12551–12556
  55. Pashenkov M, Teleshova N, Kouwenhoven M, et al.  Recruitment of dendritic cells to the cerebrospinal fluid in bacterial neuroinfections. J Neuroimmunol. 2002;122:106–116
  56. Penna G, Vulcano M, Roncari A, et al.  Cutting edge: Differential chemokine production by myeloid and plasmacytoid dendritic cells. J Immunol. 2002;169:6673–6676
  57. Petrella T, Comeau MR, Maynadie M, et al.  ‘Agranular CD4+ CD56+ hematodermic neoplasm’ (blastic NK-cell lymphoma) originates from a population of CD56+ precursor cells related to plasmacytoid monocytes. Am J Surg Pathol. 2002;26:852–862
  58. Petrella T, Dalac S, Maynadie M, et al.  CD4+ CD56+ cutaneous neoplasms: A distinct hematological entity? Groupe Francais d’Etude des Lymphomes Cutanes (GFELC). Am J Surg Pathol. 1999;23:137–146
  59. Prasthofer EF, Prchal JT, Grizzle WE, et al.  Plasmacytoid T-cell lymphoma associated with chronic myeloproliferative disorder. Am J Surg Pathol. 1985;9:380–387
  60. Pulford KA, Sipos A, Cordell JL, et al.  Distribution of the CD68 macrophage/myeloid associated antigen. Int Immunol. 1990;2:973
  61. Radonich MA, Lazova R, Bolognia J. Cutaneous natural killer/T-cell lymphoma. J Am Acad Dermatol. 2002;46:451–456
  62. Res PC, Couwenberg F, Vyth-Dreese FA, et al.  Expression of pTalpha mRNA in a committed dendritic cell precursor in the human thymus. Blood. 1999;94:2647–2657
  63. Rissoan MC, Soumelis V, Kadowaki N, et al.  Reciprocal control of T helper cell and dendritic cell differentiation. Science. 1999;283:1183–1186
  64. Savoia P, Fierro MT, Novelli M, et al.  CD56-positive cutaneous lymphoma: A poorly recognized entity in the spectrum of primary cutaneous disease. Br J Dermatol. 1997;137:966–971
  65. Servet C, Zitvogel L, Hosmalin A. Dendritic cells in innate immune responses against HIV. Curr Mol Med. 2002;2:739–756
  66. Siegal FP, Kadowaki N, Shodell M, et al.  The nature of the principal type 1 interferon-producing cells in human blood. Science. 1999;284:1835–1837
  67. Siu LL, Chan JK, Kwong YL. Natural killer cell malignancies: Clinicopathologic and molecular features. Histol Histopathol. 2002;17:539–554
  68. Svensson H, Johannisson A, Nikkila T, et al.  The cell surface phenotype of human natural interferon-alpha producing cells as determined by flow cytometry. Scand J Immunol. 1996;44:164–172
  69. Touahri T, Belaouni H, Mossafa H, et al.  Agranular CD4+/CD56+ cutaneous neoplasm. Leuk Lymphoma. 2002;43:1475–1479
  70. Uchiyama N, Ito K, Kawai K, et al.  CD2-, CD4+, CD56+ agranular natural killer cell lymphoma of the skin. Am J Dermatopathol. 1998;20:513–517
  71. Vremec D, Zorbas M, Scollay R, et al.  The surface phenotype of dendritic cells purified from mouse thymus and spleen: Investigation of the CD8 expression by a subpopulation of dendritic cells. J Exp Med. 1992;176:47–58
  72. Wasik MA, Sackstein R, Novick D, et al.  Cutaneous CD56+ large T-cell lymphoma associated with high serum concentration of IL-2. Hum Pathol. 1996;27:738–744
  73. Wood GS, Warner NL, Warnke RA. Anti-Leu-3/T4 antibodies react with cells of monocyte/macrophage and Langerhans lineage. J Immunol. 1983;131:212–216
  74. Woodford-Thomas T, Thomas ML. The leukocyte common antigen, CD45 and other protein tyrosine phosphatases in hematopoietic cells. Semin Cell Biol. 1993;4:409–418
  75. Zou M, Borvak J, Wei S, et al.  Reciprocal regulation of plasmacytoid dendritic cells and monocytes during viral infection. Eur J Immunol. 2001;31:3833–3839
  76. Zou W, Machelon V, Coulomb-L’Hermin A, et al.  Stromal-derived factor-1 in human tumors recruits and alters the function of plasmacytoid precursor dendritic cells. Nat Med. 2001;7:1339–1346

PII: S0037-1963(03)00139-2

Seminars in Hematology
Volume 40, Issue 3 , Pages 257-266 , July 2003

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