Seminars in Hematology
Volume 40, Issue 3 , Pages 257-266, July 2003

Plasmacytoid dendritic cells: From the plasmacytoid T-cell to type 2 dendritic cells CD4+CD56+ malignancies

  • Marie C. Béné

      Affiliations

    • *Address correspondence to Marie C. Béné, PhD, Laboratoire d’Immunologie du CHU, Faculté de Médecine, BP 184, 9 Avenue de la Forêt de Haye, 54500, Vandoeuvre les Nancy, France
    • Laboratoire d’Immunologie du CHU, Faculté de Médecine, Nancy, France
    • ,
  • Jean Feuillard

      Affiliations

    • Laboratoire d’Hématologie, CHU Dupuytren, Limoges, France
    • ,
  • Marie C. Jacob

      Affiliations

    • Department of Research and Development, Groupe de Recherche sur les Lymphomes, EFS Rhône-Alpes Grenoble, La Tronche, France
    • ,
  • the Groupe d’Etude Immunologique des Leucémies

Abstract 

Recent identification of CD4+CD56+ malignancies as pathological counterparts of the precursors of type 2 dendritic cells (DC2) has shed new light on a leukocyte lineage that long remained elusive. This review retraces how knowledge evolved, through careful examination and analysis of both normal lymphoid tissue and rare proliferative diseases, from plasmacytoid T cells to plasmacytoid dendritic cells (pDC) and then DC2. The functions of these cells and their key role at the crossroads of innate and cognitive immunity are also discussed. The major characteristics of DC2 malignancies are summarized and compared to natural killer cell (NK) lymphomas, another type of proliferative disease sharing the expression of CD56.

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PII: S0037-1963(03)00139-2

Seminars in Hematology
Volume 40, Issue 3 , Pages 257-266, July 2003

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