Seminars in Hematology
Volume 40, Issue 3 , Pages 213-220, July 2003

Survival signals in leukemic large granular lymphocytes☆

  • P.K. Epling-Burnette

      Affiliations

    • *Address correspondence to P.K. Epling-Burnette, PhD, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Dr, Tampa, FL 33612, USA
    • Hematology Malignancy Program, H. Lee Moffitt Cancer Center and Research Institute, University of South FloridaTampa, FL, USA
    • James A. Haley Veterans’ Administration Hospital, Tampa, FL, USA
    • ,
  • Thomas P. Loughran Jr

      Affiliations

    • Hematology Malignancy Program, H. Lee Moffitt Cancer Center and Research Institute, University of South FloridaTampa, FL, USA
    • James A. Haley Veterans’ Administration Hospital, Tampa, FL, USA

Abstract 

The central hypothesis of our laboratory research program in large granular lymphocyte (LGL) leukemia is that leukemic LGL represent antigen-driven cytotoxic T lymphocytes (CTL) with characteristics of dysregulated apoptosis. The clinical features of LGL leukemia highlight the association of autoimmune diseases such as rheumatoid arthritis with the T-cell form of LGL leukemia. We therefore used LGL leukemia as a model disease of dysregulated apoptosis leading to both malignant and autoimmune diseases. Here, we review our understanding of survival signals activated in leukemic LGL in the context of knowledge concerning apoptotic pathways in activated normal lymphocytes.

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☆ Supported by Veterans’ Administration Merit Review grants and NCI Grants No. CA83947 and CA90633.

PII: S0037-1963(03)00135-5

Seminars in Hematology
Volume 40, Issue 3 , Pages 213-220, July 2003

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