Seminars in Hematology
Volume 37, Issue 3 , Pages 249-260 , July 2000

Advances in the diagnosis of idiopathic thrombocytopenic purpura

  • Beng H Chong

      Affiliations

    • Corresponding Author InformationAddress reprint requests to BengH. Chong, MBBS, PhD, Prince of Wales Hospital, Department of Haematology, Level 4, Campus Centre, Barker Street, Randwick NSW 2031, Australia.
  • ,
  • Tee Beng Keng

References 

  1. Beardsley DS. Platelet autoantigens: Identification and characterization using immunoblotting. Blut. 1989;59:47–51
  2. Beardsley DS, Spiegel JE, Jacobs MM, et al.  Platelet membrane glycoprotein IIIa contains target antigens that bind antiplatelet antibodies in immune thrombocytopenias. J Clin Invest. 1984;74:1701–1707
  3. Berchtold P, Harris JP, Tani P, et al.  Autoantibodies to platelet glycoproteins in patients with disease-related immune thrombocytopenia. Br J Haematol. 1989;73:365–368
  4. Berchtold P, Muller D, Beardsley D, et al.  International study to compare antigen-specific methods used for the measurement of antiplatelet autoantibodies. Br J Haematol. 1997;96:477–483
  5. Berchtold P, Muller D, Kouns WC, et al.  Plasma autoantibodies against platelet glycoprotein IIb/IIIa from patients with autoimmune thrombocytopenic purpura may recognize different antigenic determinants. Eur J Haematol. 1998;61:223–228
  6. Berchtold P, Wenger M. Autoantibodies against platelet glycoproteins in autoimmune dirombocytopenic purpura: Their clinical significance and response to treatment. Blood. 1993;81:1246–1250
  7. Bierling P, Bettaieb A, Fromont P, et al.  Anti-GMP140 (CD 62) autoantibody in a patient with autoimmune thrombocytopenic purpura. Br J Haematol. 1994;87:631–633
  8. Brighton T, Evans S, Castaldi CN, et al.  Prospective evaluation of clinical usefulness of an antigen-specific assay (MAIPA) in idiopathic dirombocytopenic purpura and other immune thrombocytopenias. Blood. 1996;88:194–201
  9. Calpin C, Dick P, Poon A, et al.  Is bone marrow aspiration needed in acute childhood idiopadiic thrombocytopenic purpura to rule out leukaemia?. Arch Pediatr Adolesc Med. 1998;152:345–347
  10. Chong BH, Burgess J, Ismail F. The clinical usefulness of the platelet aggregation test for the diagnosis of heparin-induced thrombocytopenia. Thromb Haemost. 1993;69:344–350
  11. Chong BH, Castaldi PA. Platelet proaggregating effect of heparin: Possible mechanism for non-immune heparin-associated thrombocytopenia. Aust NZ J Med. 1986;16:715–716
  12. Christopoulos CG, Kelsey HC, Machin SJ. A flow cytometric approach to quantitative estimation of platelet surface immunoglobulin G. Vox Sang. 1993;64:106–115
  13. Crossley A, Calvert JE, Taylor PR, et al.  A comparison of monoclonal antibody immobilization of platelet antigen (MAIPA) and immunobead methods for detection of GP IIb/IIIa antiplatelet antibodies in immune thrombocytopenic purpura. Transfus Med. 1997;7:127–134
  14. Dixon R, Rosse W, Ebbert L. Quantitative determination of antibody in idiopathic thrombocytopenic purpura. N Engl J Med. 1975;292:230–236
  15. Fujisawa K, Tani P, O'Toole TE, et al.  Different specificities of pktelet-associated and plasma autoantibodies to platelet GP IIb/IIIa in patients with chronic immune dirombocytopenic purpura. Blood. 1992;79:1441–1446
  16. George JN. Platelet IgG measurement, interpretation, and clinical significance. Prog HemostThromb. 1991;10:97–126
  17. George JN, Raskob GE. Idiopathic thrombocytopenic purpura: A concise summary of the pathophysiology and diagnosis in children and adults. In: Semin Haematol. 35:1998;p. 5–8 (suppl)
  18. George JN, Saucerman S, Levine SP, et al.  Immunoglobulin G is a platelet alpha granule-secreted protein. J Clin Invest. 1985;76:2020–2025
  19. George JN, Woolf SH, Raskob GE, et al.  Idiopathic thrombocytopenic purpura: A practice guideline developed by explicit methods for the American Society of Hematology. Blood. 1996;88:3–40
  20. Halperin DS, Doyle JJ. Is bone marrow examination justified in idiopathic thrombocytopenic purpura?. Am J Dis Child. 1988;142:508–511
  21. Harrington W, Minnich V, Hollingsworth JW, et al.  Demonstration of a thrombocytopenic factor in the blood of patients with thrombocytopenic purpura. J Lab Clin Med. 1951;38:1–10
  22. He R, Reid DM, Jones CE, et al.  Spectrum of Ig classes, specificities, and titers of serum antiglycoproteins in chronic idiopathic thrombocytopenic purpura. Blood. 1994;83:1024–1032
  23. Hebbar M, Kaplan MT, Caulier E, et al.  Low incidence of specific anti-platelet antibodies detected by the MAIPA assay in the serum of thrombocytopenic MDS patients and lack of correlation between platelet antibodies, platelet lifespan and response to danazol therapy. Br J Haematol. 1996;94:112–115
  24. Hegde UM, Bowes A, Powell DK, et al.  Detection of platelet-bound and serum antibodies in autoimmune throm-bocytopenia by enzyme-linked assay. Vox Sang. 1981;41:306–312
  25. Hurlimann-Forster M, Steiner B, Von Feiten A. Quantitation of platelet-specific autoantibodies in platelet eluates of ITP patients measured by a novel ELISA using the purified glycoprotein complexes GP IIb/IIIa and GP Ib/IX as antigens. Br J Haematol. 1997;98:328–335
  26. Joutsi L, Kekomaki R. Comparison of the direct platelet immunofluorescence test (direct PIFT) with a modified direct monoclonal antibody-specific immobilization of platelet antigens (direct MAIPA) in detection of platelet-associated IgG. Br J Haematol. 1997;96:204–209
  27. Kelton JG. The serological investigation of patients with autoimmune thrombocytopenia. Thromb Haemost. 1995;74:228–233
  28. Kelton JG, Denomme G, Lucarelli A, et al.  Comparison of the measurement of surface or total platelet-associated IgG in the diagnosis of immune thrombocytopenia. Am J Hematol. 1985;18:1–5
  29. Kelton JG, Murphy WG, Lucarelli A, et al.  A prospective comparison of four techniques for measuring platelet- associated IgG. Br J Haematol. 1989;71:97–105
  30. Kelton JG, Powers PJ, Carter CJ. A prospective study of the usefulness of the measurement of platelet-associated IgG for the diagnosis of idiopathic thrombocytopenic purpura. Blood. 1982;60:1050–1053
  31. Kelton JG, Smith JW, Horsewood P, et al.  Gova/b alloantigen system on human platelets. Blood. 1990;75:2127–2176
  32. Kelton JG, Steeves K. The amount of platelet-bound albumin parallels the amount of IgG on washed platelets from patients with immune thrombocytopenia. Blood. 1983;62:924–927
  33. Kiefel V, Freitag E, Kroll H, et al.  Platelet autoantibodies (IgG, IgM, IgA) against glycoproteins IIb/IIIa and Ib/IX in patients with thrombocytopenia. Ann Hematol. 1996;72:280–285
  34. Kiefel V, Santoso S, Kaufmann E, et al.  Autoantibodies against platelet glycoprotein Ib/IX: A frequent finding in autoimmune thrombocytopenia purpura. Br J Haematol. 1991;79:256–262
  35. Kiefel V, Santoso S, Weisheit M, et al.  Monoclonal antibodyspecific immobilization of platelet antigens (MAIPA): A new tool for the identification of platelet-reactive antibodies. Blood. 1987;70:1722–1726
  36. Kunicki TJ, Koenig MB, Kristopeit SM, et al.  Direct quantitation of platelet-associated IgG by electroimmunoassay. Blood. 1982;60:54–58
  37. Leporrier M, Dighiero G, Auzemery M, et al.  Detection and quantitation of platelet-bound antibodies with immunoperoxidase. Br J Haematol. 1979;42:605–611
  38. LoBuglio AF, Court WS, Vinocur L, et al.  Immune thrombocytopenic purpura. Use of a 125I-labeled antihuman IgG monoclonal antibody to quantify plate-bound IgG. N Engl J Med. 1983;309:459–463
  39. Luiken GA, McMillan R, Lightsey AL, et al.  Platelet-associated IgG in immune thrombocytopenic purpura (ITP). Blood. 1977;50:317–325
  40. Lynch DM, Howe SE. Antigenic determinants in idiopathic thrombocytopenic purpura. Br J Haematol. 1986;63:301–308
  41. Macchi L, Clofent-Sanchez G, Mark G, Bihour C, et al.  PAICA A method for characterizing platelet-associated antibodies—Its application to the study of idiopathic thrombocytopenic purpura and to the detection of platelet-bound c7E3. Thromb Haemost. 1996;76:1020–1029
  42. Menitove JE, Pereira J, Hoffman R, et al.  Cyclic thrombocytopenia of apparent autoimmune etiology. Blood. 1989;73:1561–1569
  43. McMillan R. Antigen-specific assays in immune thrombocytopenia. Transfus Med Rev. 1990;4:136–143
  44. McMillan R, Luiken GA, Gordon P, et al.  Platelet-associated IgG (PAIgG)—An assay of antiplatelet antibody in immune thrombocytopenic purpura (ITP). Blood. 1975;46:1034
  45. McMillan R, Smith RS, Longmire RL, et al.  Immunoglobulin associated with human platelets. Blood. 1971;37:316–322
  46. McMillan R, Tani P, Millard F, et al.  Platelet-associated and plasma antiglycoprotein autoantibodies in chronic ITP. Blood. 1987;70:1040–1045
  47. Morse BS, Giuliani D, Nussbaum M. A rapid quantitation of platelet-associated IgG by nephelometry. Am J Hematol. 1982;12:217–275
  48. Morse BS, Giuliani D, Nussbaum M. Quantitation of pktelet-associated IgG by radial immunodifrusion. Blood. 1981;57:809–811
  49. Mueller-Eckhardt C, Mueller-Eckhardt G, Kayser W, et al.  Platelet-associated IgG, platelet survival, and platelet sequestration in thrombocytopenic states. Br J Haematol. 1982;52:49–58
  50. Nomura S, Yanabu M, Soga T, et al.  Analysis of idiopathic thrombocytopenic purpura patients with antiglycoprotein IIb/IIIa or Ib autoantibodies. Acta Haematol. 1991;86:25–30
  51. Pereira J, Accatino L, Alfaro J, et al.  Platelet autoantibodies in patients with chronic liver disease. Am J Hematol. 1995;50:173–178
  52. Reid DM, Jones CE, Vostal JG, et al.  Western blot identification of platelet proteins that bind normal serum immunoglobulins. Characteristics of a 95-Kd reactive protein. Blood. 1990;75:2194–2203
  53. Shaw GM, Axelson J, Maglott JG, et al.  Quantification of platelet-bound IgG by 125I-staphylococcal protein A in immune thrombocytopenic purpura and other thrombocytopenic disorders. Blood. 1984;63:154–161
  54. Sheridan D, Carter C, Kelton JG. A diagnostic test for heparin-induced thrombocytopenia. Blood. 1986;67:27–30
  55. Shulman NR, Malder VF, Weinrach RS. Similarities between known antiplatelet antibodies and the factor responsible for thrombocytopenia in idiopathic thrombocytopenic purpura: Physiologic, serologic and isotopic studies. Ann NY Acad Sci. 1965;124:499–542
  56. Sinha RJ, Kelton JG. Current controversies concerning the measurement of platelet-associated IgG. Transfus Med Rev. 1990;5:121–135
  57. Smith JW, Kelton JG, Horsewood P, et al.  Platelet-specific alloantigens (Zava/Zavb) on the platelet glycoprotein Ia/IIa complex. Br J Haematol. 1989;72:534–538
  58. Stockelberg D, Hou M, Jacobsson S, et al.  Detection of platelet antibodies in chronic idiopathic thrombocytopenic purpura (ITP). A comparative study using flow cytometry, a whole platelet ELISA, and an antigen capture ELISA. Eur J Haematol. 1996;56:72–77
  59. Tomiyama Y, Kurata Y, Mizutani H, et al.  Platelet glycoprotein IIb as a target antigen in two patients with chronic idiopathic thrombocytopenic purpura. Br J Haematol. 1987;66:535–538
  60. Tomiyama Y, Take H, Honda S, et al.  Demonstration of platelet antigens that bind platelet-associated autoantibodies in chronic ITP by direct immunoprecipitation procedure. Br J Haematol. 1990;75:92–98
  61. van Leeuwen EF, Van der Ven J, Engelfriet CE, et al.  Specificity of autoantibodies in autoimmune thrombocytopenia. Blood. 1982;59:23–26
  62. Warner M, Kelton JG. Laboratory investigation of immune thrombocytopenia. J Clin Pathol. 1997;50:5–12
  63. Warner MM, Moore JC, Warkentin TE, et al.  A prospective study of protein-specific assays used to investigate idiopathic thrombocytopenic purpura. Br J Haematol. 1999;104:442–447
  64. Westerman DA, Grigg AP. The diagnosis of idiopathic thrombocytopenic purpura in adults: Does bone marrow biopsy have a place?. Med J Aust. 1999;170:216–217
  65. Woods VL, Kurata Y, Montgomery RR, et al.  Autoantibodies against platelet glycoprotein Ib in patients with chronic immune thrombocytopenic purpura. Blood. 1984;64:156–160
  66. Woods VL, Oh EH, Mason D, et al.  Autoantibodies against the platelet glycoprotein IIb/IIIa complex in patients with chronic ITP. Blood. 1984;63:368–375

PII: S0037-1963(00)90103-3

Seminars in Hematology
Volume 37, Issue 3 , Pages 249-260 , July 2000